GenAge entry for PLAU (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 10)

HGNC symbol
PLAU 
Aliases
URK; UPA 
Common name
plasminogen activator, urokinase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

PLAU is a protease that converts plasminogen to plasmin. It appears to affect murine ageing: its overexpression in the brain diminishes food consumption and extends longevity probably through a mechanism similar to caloric restriction [13]. It is unclear at present whether PLAU affects human ageing, despite some evidence linking PLAU to age-related neurological diseases [374].

Cytogenetic information

Cytogenetic band
10q22.2
Location
73,911,104 bp to 73,917,500 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001666; response to hypoxia
GO:0006508; proteolysis
GO:0006935; chemotaxis
GO:0007165; signal transduction
GO:0007596; blood coagulation
GO:0010469; regulation of receptor activity
GO:0014909; smooth muscle cell migration
GO:0014910; regulation of smooth muscle cell migration
GO:0030335; positive regulation of cell migration
GO:0033628; regulation of cell adhesion mediated by integrin
GO:0042127; regulation of cell proliferation
And 4 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0070062; extracellular exosome
Function: GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
HRAS, MYC, LRP2, SERPINE1
STRING interaction network
Protein-Protein network diagram for PLAU

Retrieve sequences for PLAU

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
svh-1
Danio rerio
plaub
Danio rerio
plaua
Mus musculus
Plau
Rattus norvegicus
Plau

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Plau

Selected references

External links

EPD
HS_PLAU
ORF Accession
NM_002658
CDS Accession
NP_002649
OMIM
191840
HPRD
01883
Ensembl
PLAU
UniProt/Swiss-Prot
UROK_HUMAN
GeneCards
PLAU
Entrez Gene
5328
GenAtlas
PLAU
Internet
Search Google