GenAge entry for HSPA1B (Homo sapiens)
Gene name (HAGRID: 161)
- HGNC symbol
- HSPA1B
- Aliases
- HSP70-2
- Common name
- heat shock 70kDa protein 1B
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
HSPA1B is involved in stress response and recognition of abnormal proteins, but also in signalling cascades. Results from invertebrates have suggested that heat-shock proteins, such as hsp70, a homologue of HSPA1B, are involved in ageing [210]. Whether HSPA1B is involved in human ageing is unknown.
Cytogenetic information
- Cytogenetic band
- 6p21.3
- Location
- 3,075,514 bp to 3,078,033 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0010628; positive regulation of gene expression
GO:0010941; regulation of cell death
GO:0031396; regulation of protein ubiquitination
GO:0031397; negative regulation of protein ubiquitination
GO:0032757; positive regulation of interleukin-8 production
GO:0034599; cellular response to oxidative stress
GO:0034605; cellular response to heat
GO:0042026; protein refolding
GO:0046034; ATP metabolic process
GO:0046718; viral entry into host cell
GO:0050821; protein stabilization
And 9 more GO terms Cellular component: GO:0000151; ubiquitin ligase complex
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005814; centriole
GO:0005829; cytosol
GO:0005925; focal adhesion
GO:0016234; inclusion body
GO:0048471; perinuclear region of cytoplasm
GO:0072562; blood microparticle
Function: GO:0001618; virus receptor activity
GO:0001664; G-protein coupled receptor binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0019899; enzyme binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0042623; ATPase activity, coupled
GO:0042826; histone deacetylase binding
And 4 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, EGFR, HSP90AA1, GRB2, YWHAZ, CTNNB1, STUB1
- STRING interaction network
Retrieve sequences for HSPA1B
Homologs in model organisms
- Caenorhabditis elegans
- hsp-1
- Danio rerio
- hsp70l
- Danio rerio
- hsp70.3
- Danio rerio
- si:ch211-199o1.2
- Drosophila melanogaster
- Hsc70-4
- Drosophila melanogaster
- Hsc70-1
- Mus musculus
- Hspa1a
- Mus musculus
- Hspa1b
- Rattus norvegicus
- Hspa1b
- Rattus norvegicus
- Hspa1a
- Rattus norvegicus
- Hspa1a
- Rattus norvegicus
- Hspa1b
- Saccharomyces cerevisiae
- SSA1
In other databases
- LongevityMap
- This gene is present as HSPA1B