GenAge entry for NGFR (Homo sapiens)

Gene name (HAGRID: 37)

HGNC symbol
NGFR 
Aliases
TNFRSF16; CD271; p75NTR 
Common name
nerve growth factor receptor 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

A receptor that can bind not only NGF but other neurotrophins, such as BDNF, NGFR mediates neural cell survival and is an important player in development. Results from mice suggest it may be related to brain ageing [337], though if and how it impacts on the human ageing process is not known.

Cytogenetic information

Cytogenetic band
17q21-q22
Location
49,495,293 bp to 49,515,020 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006886; intracellular protein transport
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007411; axon guidance
GO:0010977; negative regulation of neuron projection development
GO:0031293; membrane protein intracellular domain proteolysis
GO:0032496; response to lipopolysaccharide
GO:0032922; circadian regulation of gene expression
GO:0033209; tumor necrosis factor-mediated signaling pathway
GO:0042127; regulation of cell proliferation
And 16 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005768; endosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009986; cell surface
GO:0043005; neuron projection
Function: GO:0004871; signal transducer activity
GO:0004872; receptor activity
GO:0004888; transmembrane signaling receptor activity
GO:0005031; tumor necrosis factor-activated receptor activity
GO:0005515; protein binding
GO:0017137; Rab GTPase binding
GO:0031625; ubiquitin protein ligase binding
GO:0048406; nerve growth factor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, NGF, NGFR, H2AFX, CDKN1A, IKBKB, SQSTM1
STRING interaction network
Protein-Protein network diagram for NGFR

Retrieve sequences for NGFR

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ngfra
Danio rerio
ngfrb
Mus musculus
Ngfr
Rattus norvegicus
Ngfr

Selected references

External links

EPD
ORF Accession
NM_002507
CDS Accession
NP_002498
OMIM
162010
HPRD
01197
Ensembl
NGFR
UniProt/Swiss-Prot
TNR16_HUMAN
GeneCards
NGFR
Entrez Gene
4804
UniGene
415768
GenAtlas
NGFR
Internet
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