GenAge entry for TERC (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 7)
- HGNC symbol
- TERC
- Aliases
- TR; hTR; TRC3; DKCA1; PFBMFT2; SCARNA19
- Common name
- telomerase RNA component
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
The RNA component of telomerase, TERC is involved in elongating the telomeres and is a critical factor in cellular senescence [21].
TERC disruption in mice shortens lifespan and increases tumour incidence but it does not appear to accelerate ageing [29]. Late-generation mice with disrupted TERC, and hence with shorter telomeres, when combined with mutations in ATM [12] or WRN [1069] may suffer from accelerated ageing. Telomere shortening in mice lacking TERC also appears to impact on the pathologies caused by mutations in BLM [1149]. Human mutations in TERC are a cause of dyskeratosis congenita, a skin and bone marrow failure syndrome which is not classified as accelerated ageing [114].
Cytogenetic information
- Cytogenetic band
- 3q26
- Location
- 169,764,609 bp to 169,765,060 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: Cellular component:
Show all GO termsFunction:
Protein interactions and network
Retrieve sequences for TERC
- ORF
- ORF
Homologs in model organisms
No homologs found
In other databases
- LongevityMap
- This gene is present as TERC