GenAge entry for HSPD1 (Homo sapiens)

Gene name (HAGRID: 159)

HGNC symbol
HSPD1 
Aliases
GroEL; HSP60; SPG13 
Common name
heat shock 60kDa protein 1 (chaperonin) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

HSPD1 plays a role in stress response in the mitochondria [753]. Heat-shock proteins have been suggested as a player in the ageing of model organisms such as invertebrates. Age-related changes in heat-shock proteins, including HSPD1, have also been reported in rats [1644]. A mutation in the human HSPD1 gene has been associated with spastic paraplegia [1713]. HSPD1's relevance to human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
2q33.1
Location
197,486,584 bp to 197,499,916 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002368; B cell cytokine production
GO:0002755; MyD88-dependent toll-like receptor signaling pathway
GO:0002842; positive regulation of T cell mediated immune response to tumor cell
GO:0006458; 'de novo' protein folding
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986; response to unfolded protein
GO:0008637; apoptotic mitochondrial changes
GO:0009409; response to cold
GO:0016032; viral process
GO:0032727; positive regulation of interferon-alpha production
GO:0032729; positive regulation of interferon-gamma production
And 18 more GO terms
Cellular component: GO:0005615; extracellular space
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005759; mitochondrial matrix
GO:0005769; early endosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005905; clathrin-coated pit
GO:0009986; cell surface
GO:0016020; membrane
And 9 more GO terms
Function: GO:0001530; lipopolysaccharide binding
GO:0002039; p53 binding
GO:0003688; DNA replication origin binding
GO:0003697; single-stranded DNA binding
GO:0003725; double-stranded RNA binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0031625; ubiquitin protein ligase binding
GO:0044183; protein binding involved in protein folding
GO:0044822; poly(A) RNA binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
MYC, PLCG2, BRCA1, PTEN, VCP, NR3C1, ABL1, EEF2, BAX, GRB2, APP, RAD52, SIRT1, HDAC1, HSPA9, GSR, HSPA1A, MAPK14, ATF2, HSPA8, ESR1, CLU, STUB1, PCK1, SIRT3, BAK1
STRING interaction network
Protein-Protein network diagram for HSPD1

Retrieve sequences for HSPD1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsp-60
Danio rerio
hspd1
Drosophila melanogaster
Hsp60B
Drosophila melanogaster
Hsp60D
Drosophila melanogaster
Hsp60
Drosophila melanogaster
Hsp60C
Mus musculus
Hspd1
Rattus norvegicus
Hspd1
Saccharomyces cerevisiae
HSP60
Schizosaccharomyces pombe
hsp60

Selected references

External links

EPD
HS_HSPD1
ORF Accession
NM_002156
CDS Accession
NP_002147
OMIM
118190
HPRD
00318
Ensembl
HSPD1
UniProt/Swiss-Prot
CH60_HUMAN
GeneCards
HSPD1
Entrez Gene
3329
UniGene
595053
GenAtlas
HSPD1
Internet
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