GenAge entry for TFDP1 (Homo sapiens)

Gene name (HAGRID: 202)

HGNC symbol
TFDP1 
Aliases
Dp-1; DRTF1; DP1 
Common name
transcription factor Dp-1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

TFDP1 is a transcription factor that may play a role in cell cycle regulation and apoptosis [878]. Despite its association with cellular senescence [1569], TFDP1 has not been directly linked to organismal ageing.

Cytogenetic information

Cytogenetic band
13q34
Location
113,584,741 bp to 113,641,473 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008283; cell proliferation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0070345; negative regulation of fat cell proliferation
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005739; mitochondrion
Function: GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019904; protein domain specific binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, E2F1, CREBBP, RB1, CDK1, MAX, TP53BP1
STRING interaction network
Protein-Protein network diagram for TFDP1

Retrieve sequences for TFDP1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
dpl-1
Danio rerio
tfdp1a
Drosophila melanogaster
Dp
Mus musculus
Tfdp1
Rattus norvegicus
Tfdp1

In other databases

CellAge
  • This gene is present as TFDP1

Selected references

External links

EPD
ORF Accession
NM_007111
CDS Accession
NP_009042
OMIM
189902
HPRD
01792
Ensembl
TFDP1
UniProt/Swiss-Prot
TFDP1_HUMAN
GeneCards
TFDP1
Entrez Gene
7027
UniGene
79353
GenAtlas
TFDP1
Internet
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