GenAge entry for HMGB2 (Homo sapiens)
Gene name (HAGRID: 178)
- HGNC symbol
- HMGB2
- Aliases
- HMG2
- Common name
- high mobility group box 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
HMGB2 has been related to DNA unwinding and stress response. In mice, HMGB2 and other HMG chromosomal proteins have been shown to suffer alterations at various levels during ageing [790], though HMGB2 has not been directly related to human ageing.
Cytogenetic information
- Cytogenetic band
- 4q31
- Location
- 173,331,376 bp to 173,334,444 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001938; positive regulation of endothelial cell proliferation
GO:0002437; inflammatory response to antigenic stimulus
GO:0006265; DNA topological change
GO:0006309; apoptotic DNA fragmentation
GO:0006325; chromatin organization
GO:0006334; nucleosome assembly
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0007289; spermatid nucleus differentiation
GO:0008584; male gonad development
GO:0032075; positive regulation of nuclease activity
And 24 more GO terms Cellular component: GO:0000790; nuclear chromatin
GO:0000793; condensed chromosome
GO:0005615; extracellular space
GO:0005623; cell
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0043234; protein complex
GO:0048471; perinuclear region of cytoplasm
Function: GO:0000400; four-way junction DNA binding
GO:0001158; enhancer sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003684; damaged DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008144; drug binding
GO:0008301; DNA binding, bending
And 8 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- CREBBP, NR3C1, AR, APP, HMGB1
- STRING interaction network
Retrieve sequences for HMGB2
Homologs in model organisms
- Caenorhabditis elegans
- hmg-1.2
- Danio rerio
- hmgb2a
- Drosophila melanogaster
- Dsp1
- Mus musculus
- Hmgb2
- Rattus norvegicus
- RGD1559962
- Rattus norvegicus
- Hmgb2l1
- Rattus norvegicus
- RGD1561694
- Rattus norvegicus
- Hmgb2
- Rattus norvegicus
- Hmgb2l1
- Saccharomyces cerevisiae
- NHP6A
- Saccharomyces cerevisiae
- NHP6B