GenAge entry for PTPN11 (Homo sapiens)

Gene name (HAGRID: 19)

HGNC symbol
PTPN11 
Aliases
BPTP3; SH-PTP2; SHP-2; PTP2C; SHP2; NS1 
Common name
protein tyrosine phosphatase, non-receptor type 11 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PTPN11 is a signalling protein that plays a role in the signal transduction of many receptors that have been associated with ageing, such as GHR [1559]. Mutations in PTPN11 cause Noonan syndrome, which is often characterized by growth impairment and a disturbance of GH1 secretion and IGF1 signalling, even though this disease is probably due to a gain-of-function mutation [257]. It is unknown whether PTPN11 plays a role in human ageing, but it may play a role in its signalling cascade.

Cytogenetic information

Cytogenetic band
12q24
Location
112,418,732 bp to 112,509,913 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000077; DNA damage checkpoint
GO:0000187; activation of MAPK activity
GO:0006641; triglyceride metabolic process
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007229; integrin-mediated signaling pathway
GO:0007409; axonogenesis
GO:0007420; brain development
GO:0007507; heart development
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0009755; hormone-mediated signaling pathway
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
And 42 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0043234; protein complex
Function: GO:0004721; phosphoprotein phosphatase activity
GO:0004725; protein tyrosine phosphatase activity
GO:0004726; non-membrane spanning protein tyrosine phosphatase activity
GO:0005070; SH3/SH2 adaptor activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0019904; protein domain specific binding
GO:0030971; receptor tyrosine kinase binding
GO:0031748; D1 dopamine receptor binding
GO:0043274; phospholipase binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, IGF1R, PTPN11, STAT5B, STAT3, STAT5A, IRS1, IRS2, EGFR, ERBB2, INSR, PDGFRB, EPOR, PLCG2, GSK3B, GRB2, PTK2B, PTK2, MAPK14, FLT1, MAP3K5, PIK3R1, JAK2, CTNNB1
STRING interaction network
Protein-Protein network diagram for PTPN11

Retrieve sequences for PTPN11

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ptp-2
Danio rerio
ptpn11a
Drosophila melanogaster
csw
Mus musculus
Ptpn11
Rattus norvegicus
Ptpn11
Schizosaccharomyces pombe
pyp3

In other databases

LongevityMap
  • This gene is present as PTPN11

Selected references

External links

EPD
ORF Accession
NM_002834
CDS Accession
NP_002825
OMIM
176876
HPRD
01470
Ensembl
PTPN11
UniProt/Swiss-Prot
PTN11_HUMAN
GeneCards
PTPN11
Entrez Gene
5781
UniGene
506852
GenAtlas
PTPN11
Internet
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