GenAge entry for RICTOR (Homo sapiens)

Gene name (HAGRID: 303)

HGNC symbol
RICTOR 
Aliases
MGC39830; AVO3; PIA; KIAA1999 
Common name
RPTOR independent companion of MTOR, complex 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

RICTOR is a protein component of MTOR Complex 2 (mTORC2) that is essential for its activity. Heterozygous male Rictor mice display a significantly decrease in median lifespan (40%) compared to wild-type controls. Liver-specific deletion of Rictor in male mice also resulted in a 30% decrease in median lifespan. In both models, the decrease in lifespan was associated with a decrease in the incidence of cancer. Inducibly deleting Rictor throughout the body in adult animals results in a stronger phenotype with a median survival of less than 1 year. No significant changes were observed for female lifespan in any of the three models. While the mechanism by which RICTOR depletion shortens male lifespan remains unknown, it seems that it is independent of the glucose tolerance role of hepatic mTORC2 and that calorie restriction does not rescue the phenotype [3486].

Cytogenetic information

Cytogenetic band
5p13.1
Location
38,937,921 bp to 39,074,408 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001938; positive regulation of endothelial cell proliferation
GO:0009790; embryo development
GO:0010468; regulation of gene expression
GO:0018105; peptidyl-serine phosphorylation
GO:0030010; establishment of cell polarity
GO:0030838; positive regulation of actin filament polymerization
GO:0030950; establishment or maintenance of actin cytoskeleton polarity
GO:0031295; T cell costimulation
GO:0031532; actin cytoskeleton reorganization
GO:0031929; TOR signaling
GO:0032008; positive regulation of TOR signaling
And 12 more GO terms
Cellular component: GO:0005829; cytosol
GO:0031932; TORC2 complex
Function: GO:0005515; protein binding
GO:0008047; enzyme activator activity
GO:0019901; protein kinase binding
GO:0043022; ribosome binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, NBN, BRCA1, GSK3B, PRKCA, SIRT1, MAPK14, MTOR, GSK3A, IKBKB
STRING interaction network
Protein-Protein network diagram for RICTOR

Retrieve sequences for RICTOR

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
rict-1
Danio rerio
rictorb
Danio rerio
rictora
Drosophila melanogaster
rictor
Mus musculus
Rictor
Rattus norvegicus
Rictor
Saccharomyces cerevisiae
TSC11
Schizosaccharomyces pombe
ste16

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Rictor
  • A homolog of this gene for Caenorhabditis elegans is present as rict-1
LongevityMap
  • This gene is present as RICTOR

Selected references

External links

EPD
ORF Accession
NM_152756
CDS Accession
NP_689969
OMIM
609022
HPRD
10682
Ensembl
RICTOR
UniProt/Swiss-Prot
RICTR_HUMAN
GeneCards
RICTOR
Entrez Gene
253260
UniGene
407926
GenAtlas
RICTOR
Internet
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