GenAge entry for BUB3 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 240)
- HGNC symbol
- BUB3
- Aliases
- BUB3L
- Common name
- BUB3 mitotic checkpoint protein
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
BUB3 is a mitotic spindle checkpoint gene encoding different isoforms. Haploinsufficiency of both BUB3 and RAE1 in mice, but not haploinsufficiency of either gene by itself, reduces lifespan and appears to accelerate ageing [1594]. BUB3-null mice are embryonic lethal [1595].
Cytogenetic information
- Cytogenetic band
- 10q26
- Location
- 123,154,244 bp to 123,165,370 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000070; mitotic sister chromatid segregation
GO:0007062; sister chromatid cohesion
GO:0007094; mitotic spindle assembly checkpoint
GO:0008608; attachment of spindle microtubules to kinetochore
GO:0031145; anaphase-promoting complex-dependent catabolic process
GO:0042787; protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051301; cell division
GO:0051321; meiotic cell cycle
GO:0051436; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437; positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
And 2 more GO terms Cellular component: GO:0000776; kinetochore
GO:0000777; condensed chromosome kinetochore
GO:0005654; nucleoplasm
GO:0005829; cytosol
GO:0033597; mitotic checkpoint complex
GO:1990298; bub1-bub3 complex
Function: GO:0005515; protein binding
GO:0043130; ubiquitin binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- EGFR, PARP1, RPA1, TOP1, HDAC1, APEX1, BUB1B, HDAC2
- STRING interaction network
Retrieve sequences for BUB3
Homologs in model organisms
- Caenorhabditis elegans
- bub-3
- Danio rerio
- bub3
- Drosophila melanogaster
- Bub3
- Mus musculus
- Bub3
- Rattus norvegicus
- Bub3
- Saccharomyces cerevisiae
- GLE2
- Schizosaccharomyces pombe
- bub3
In other databases
- GenAge model organism genes
- CellAge gene expression
- This gene is present as BUB3