GenAge entry for PTGS2 (Homo sapiens)
Gene name (HAGRID: 198)
- HGNC symbol
- PTGS2
- Aliases
- COX2
- Common name
- prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
PTGS2 may play a role in inflammation. PTGS2-null mice developed severe nephropathy [864] and female reproductive failures [1734]. Age-related changes in PTGS2 have been reported in various tissues in mice [863]. PTGS2 has not been directly related to human ageing.
Cytogenetic information
- Cytogenetic band
- 1q25.2-q25
- Location
- 186,671,812 bp to 186,680,427 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001516; prostaglandin biosynthetic process
GO:0001525; angiogenesis
GO:0006693; prostaglandin metabolic process
GO:0006769; nicotinamide metabolic process
GO:0006928; movement of cell or subcellular component
GO:0006954; inflammatory response
GO:0006979; response to oxidative stress
GO:0007566; embryo implantation
GO:0007612; learning
GO:0007613; memory
GO:0008217; regulation of blood pressure
And 49 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005788; endoplasmic reticulum lumen
GO:0005789; endoplasmic reticulum membrane
GO:0005901; caveola
GO:0031090; organelle membrane
GO:0043005; neuron projection
GO:0043234; protein complex
Function: GO:0004601; peroxidase activity
GO:0004666; prostaglandin-endoperoxide synthase activity
GO:0005515; protein binding
GO:0008289; lipid binding
GO:0019899; enzyme binding
GO:0020037; heme binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0050473; arachidonate 15-lipoxygenase activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, VCP, EP300, APP, MAPK3, PTGS2, SUMO1, CTNNB1
- STRING interaction network
Retrieve sequences for PTGS2
Homologs in model organisms
In other databases
- CellAge
- This gene is present as PTGS2
Selected references
External links
- EPD
- ORF Accession
- NM_000963
- CDS Accession
- NP_000954
- OMIM
- 600262
- HPRD
- 02599
- Ensembl
- PTGS2
- UniProt/Swiss-Prot
- PGH2_HUMAN
- GeneCards
- PTGS2
- Entrez Gene
- 5743
- GenAtlas
- PTGS2
- Internet
- Search Google