GenAge entry for CTF1 (Homo sapiens)
Gene name (HAGRID: 304)
- HGNC symbol
- CTF1
- Aliases
- CT-1; CT1
- Common name
- cardiotrophin 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
Mice lacking cardiotrophin 1 (CTF1), an interleukin 6 family member which promotes fibrosis and arterial stiffness, display decreased arterial stiffness, developed less vascular fibrosis and live longer than wild type mice [3501].
Cytogenetic information
- Cytogenetic band
- 16p11.2
- Location
- 30,896,607 bp to 30,903,560 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0007166; cell surface receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0007399; nervous system development
GO:0007517; muscle organ development
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0048666; neuron development
GO:0048861; leukemia inhibitory factor signaling pathway
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Function: GO:0005125; cytokine activity
GO:0005146; leukemia inhibitory factor receptor binding
GO:0005515; protein binding
Protein interactions and network
Retrieve sequences for CTF1
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Ctf1
Selected references
External links
- EPD
- ORF Accession
- NM_001330
- CDS Accession
- NP_001321
- OMIM
- 600435
- HPRD
- 02699
- Ensembl
- CTF1
- UniProt/Swiss-Prot
- CTF1_HUMAN
- GeneCards
- CTF1
- Entrez Gene
- 1489
- GenAtlas
- CTF1
- Internet
- Search Google