GenAge entry for CTF1 (Homo sapiens)

Gene name (HAGRID: 304)

HGNC symbol
CTF1 
Aliases
CT-1; CT1 
Common name
cardiotrophin 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

Mice lacking cardiotrophin 1 (CTF1), an interleukin 6 family member which promotes fibrosis and arterial stiffness, display decreased arterial stiffness, developed less vascular fibrosis and live longer than wild type mice [3501].

Cytogenetic information

Cytogenetic band
16p11.2
Location
30,896,607 bp to 30,903,560 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0007166; cell surface receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0007399; nervous system development
GO:0007517; muscle organ development
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0042517; positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0048666; neuron development
GO:0048861; leukemia inhibitory factor signaling pathway
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Function: GO:0005125; cytokine activity
GO:0005146; leukemia inhibitory factor receptor binding
GO:0005515; protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EP300, APP
STRING interaction network
Protein-Protein network diagram for CTF1

Retrieve sequences for CTF1

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Ctf1
Rattus norvegicus
Ctf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Ctf1

Selected references

External links

EPD
ORF Accession
NM_001330
CDS Accession
NP_001321
OMIM
600435
HPRD
02699
Ensembl
CTF1
UniProt/Swiss-Prot
CTF1_HUMAN
GeneCards
CTF1
Entrez Gene
1489
GenAtlas
CTF1
Internet
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