GenAge entry for CDK1 (Homo sapiens)
Gene name (HAGRID: 201)
- HGNC symbol
- CDK1
- Aliases
- CDC28A; CDC2
- Common name
- cyclin-dependent kinase 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
An important regulator of the cell cycle, CDK1 also appears to be involved in apoptosis. Age-related alterations to CDK1 have been reported in rats [875], but there is no direct evidence linking CDK1 to human ageing.
Cytogenetic information
- Cytogenetic band
- 10q21.1
- Location
- 60,778,454 bp to 60,794,852 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000086; G2/M transition of mitotic cell cycle
GO:0000187; activation of MAPK activity
GO:0000226; microtubule cytoskeleton organization
GO:0006260; DNA replication
GO:0006281; DNA repair
GO:0006461; protein complex assembly
GO:0006915; apoptotic process
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007067; mitotic nuclear division
And 43 more GO terms Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005813; centrosome
GO:0005829; cytosol
GO:0005876; spindle microtubule
GO:0016020; membrane
GO:0030496; midbody
GO:0070062; extracellular exosome
And 2 more GO terms Function: GO:0003682; chromatin binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004693; cyclin-dependent protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0030332; cyclin binding
GO:0030544; Hsp70 protein binding
GO:0035173; histone kinase activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, E2F1, EGFR, BRCA1, RPA1, BCL2, VCP, HSP90AA1, ABL1, UBE2I, EP300, PML, FEN1, RB1, FOXM1, UCHL1, SIRT1, SP1, HMGB1, CCNA2, LMNB1, CDK1, TFDP1, POLA1, PPP1CA, TP53BP1, CDKN1A, HTRA2, SQSTM1, CDK7
- STRING interaction network
Retrieve sequences for CDK1
Homologs in model organisms
- Caenorhabditis elegans
- cdk-1
- Danio rerio
- cdk1
- Drosophila melanogaster
- Cdk1
- Mus musculus
- Cdk1
- Rattus norvegicus
- Cdk1
- Saccharomyces cerevisiae
- CDC28