GenAge entry for TAF1 (Homo sapiens)

Gene name (HAGRID: 180)

HGNC symbol
TAF1 
Aliases
NSCL2; TAFII250; KAT4; DYT3/TAF1; TAF2A; BA2R; CCG1; CCGS; DYT3 
Common name
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Essential in cell cycle progression, TAF1 is also involved in transcription as part of the TFIID transcription factor together with TBP [891]. There is no direct evidence linking TAF1 to human ageing, but due to TAF1's importance in cell cycle control and its relation with other proteins previously related to ageing, TAF1 might play some role in human ageing.

Cytogenetic information

Cytogenetic band
Xq13.1
Location
71,366,239 bp to 71,466,005 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000209; protein polyubiquitination
GO:0006352; DNA-templated transcription, initiation
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006468; protein phosphorylation
GO:0006974; cellular response to DNA damage stimulus
GO:0007049; cell cycle
GO:0008284; positive regulation of cell proliferation
GO:0010629; negative regulation of gene expression
GO:0010767; regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
And 25 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005669; transcription factor TFIID complex
GO:0005730; nucleolus
GO:0071339; MLL1 complex
Function: GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001075; transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
GO:0001129; RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly
GO:0002039; p53 binding
GO:0003713; transcription coactivator activity
GO:0004402; histone acetyltransferase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008134; transcription factor binding
GO:0016301; kinase activity
And 8 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, MYC, FOS, UBE2I, AR, RB1, RELA, JUN, TBP, SIN3A, MAX, MDM2
STRING interaction network
Protein-Protein network diagram for TAF1

Retrieve sequences for TAF1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
taf-1
Danio rerio
taf1
Drosophila melanogaster
Taf1
Mus musculus
Taf1
Saccharomyces cerevisiae
TAF1

Selected references

External links

EPD
ORF Accession
NM_138923
CDS Accession
NP_620278
OMIM
313650
HPRD
02436
Ensembl
TAF1
UniProt/Swiss-Prot
TAF1_HUMAN
GeneCards
TAF1
Entrez Gene
6872
UniGene
158560
GenAtlas
TAF1
Internet
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