GenAge entry for HTRA2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 294)

HGNC symbol
HTRA2 
Aliases
OMI; PARK13; PRSS25 
Common name
HtrA serine peptidase 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

HTRA2 is a serine protease involved in apoptosis. Mice mutant for in Htra2 develop neurodegeneration 30–40 days after birth. However, also expressing human HTRA2 in the central nervous system rescues mice from the neurodegeneration and prevents premature death; the mice then go on to develop signs of premature ageing, including premature weight loss, hair loss, reduced fertility and kyphosis [3254]. These results suggest that HTRA2 might play a role in ageing beyond neurodegeneration, though further studies are necessary to establish this.

Cytogenetic information

Cytogenetic band
2p12
Location
74,529,405 bp to 74,533,556 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006508; proteolysis
GO:0006672; ceramide metabolic process
GO:0007005; mitochondrion organization
GO:0007568; aging
GO:0007628; adult walking behavior
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009635; response to herbicide
GO:0010822; positive regulation of mitochondrion organization
GO:0010942; positive regulation of cell death
GO:0016540; protein autoprocessing
GO:0019742; pentacyclic triterpenoid metabolic process
And 21 more GO terms
Cellular component: GO:0000785; chromatin
GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005758; mitochondrial intermembrane space
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0009898; cytoplasmic side of plasma membrane
GO:0016020; membrane
GO:0031966; mitochondrial membrane
And 2 more GO terms
Function: GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
GO:0008233; peptidase activity
GO:0008236; serine-type peptidase activity
GO:0051082; unfolded protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
VCP, MAPK14, MAPK3, EEF1A1, CDK1, HTRA2
STRING interaction network
Protein-Protein network diagram for HTRA2

Retrieve sequences for HTRA2

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
zgc:174193
Danio rerio
si:dkey-112g5.13
Danio rerio
si:dkey-10b15.8
Danio rerio
si:dkey-84o3.7
Danio rerio
BX469935.1
Danio rerio
si:dkey-112g5.14
Danio rerio
si:dkey-112g5.16
Danio rerio
zgc:173425
Danio rerio
si:dkey-112g5.13
Danio rerio
si:dkey-33c12.12
Danio rerio
si:dkey-84o3.7
Danio rerio
zgc:174193
Danio rerio
si:dkey-84o3.6
Danio rerio
si:dkey-19p15.4
Danio rerio
si:dkey-112g5.12
Danio rerio
si:dkey-112g5.11
Danio rerio
HTRA2
Danio rerio
si:dkey-265c15.6
Danio rerio
si:dkey-33c12.10
Danio rerio
si:dkey-84o3.3
Danio rerio
si:dkey-33c12.14
Danio rerio
si:dkey-33c12.12
Danio rerio
si:dkey-33c12.11
Danio rerio
si:dkey-112g5.14
Drosophila melanogaster
HtrA2
Mus musculus
Htra2
Rattus norvegicus
Htra2

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Htra2

Selected references

External links

EPD
ORF Accession
NM_013247
CDS Accession
NP_037379
OMIM
606441
HPRD
05919
Ensembl
HTRA2
UniProt/Swiss-Prot
HTRA2_HUMAN
GeneCards
HTRA2
Entrez Gene
27429
UniGene
469045
GenAtlas
HTRA2
Internet
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