GenAge entry for STK11 (Homo sapiens)

Gene name (HAGRID: 93)

HGNC symbol
STK11 
Aliases
PJS; LKB1 
Common name
serine/threonine kinase 11 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

The exact functions of STK11 are unknown, but it appears to be involved in TP53-related apoptosis [509]. Evidence suggests it may play a role in development, and it is clear that STK11 is related to tumour development [971]. STK11 has not been directly linked to human ageing.

Cytogenetic information

Cytogenetic band
19p13.3
Location
1,205,799 bp to 1,228,435 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001558; regulation of cell growth
GO:0001894; tissue homeostasis
GO:0001944; vasculature development
GO:0006468; protein phosphorylation
GO:0006914; autophagy
GO:0006974; cellular response to DNA damage stimulus
GO:0007050; cell cycle arrest
GO:0007283; spermatogenesis
GO:0007399; nervous system development
GO:0007409; axonogenesis
GO:0008285; negative regulation of cell proliferation
And 32 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0016020; membrane
GO:0036398; TCR signalosome
GO:0070062; extracellular exosome
Function: GO:0000287; magnesium ion binding
GO:0002039; p53 binding
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0030275; LRR domain binding
GO:0030295; protein kinase activator activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, HSP90AA1, GSK3B, APP, SIRT1, HSPA1A, H2AFX, TP63, STUB1
STRING interaction network
Protein-Protein network diagram for STK11

Retrieve sequences for STK11

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
par-4
Danio rerio
stk11
Drosophila melanogaster
lkb1
Mus musculus
Stk11
Rattus norvegicus
Stk11
Saccharomyces cerevisiae
SAK1
Saccharomyces cerevisiae
TOS3

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SAK1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOS3

Selected references

External links

EPD
ORF Accession
NM_000455
CDS Accession
NP_000446
OMIM
602216
HPRD
03740
Ensembl
STK11
UniProt/Swiss-Prot
STK11_HUMAN
GeneCards
STK11
Entrez Gene
6794
GenAtlas
STK11
Internet
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