GenAge entry for STK11 (Homo sapiens)
Gene name (HAGRID: 93)
- HGNC symbol
- STK11
- Aliases
- PJS; LKB1
- Common name
- serine/threonine kinase 11
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
The exact functions of STK11 are unknown, but it appears to be involved in TP53-related apoptosis [509]. Evidence suggests it may play a role in development, and it is clear that STK11 is related to tumour development [971]. STK11 has not been directly linked to human ageing.
Cytogenetic information
- Cytogenetic band
- 19p13.3
- Location
- 1,205,799 bp to 1,228,435 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001558; regulation of cell growth
GO:0001894; tissue homeostasis
GO:0001944; vasculature development
GO:0006468; protein phosphorylation
GO:0006914; autophagy
GO:0006974; cellular response to DNA damage stimulus
GO:0007050; cell cycle arrest
GO:0007283; spermatogenesis
GO:0007399; nervous system development
GO:0007409; axonogenesis
GO:0008285; negative regulation of cell proliferation
And 32 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0016020; membrane
GO:0036398; TCR signalosome
GO:0070062; extracellular exosome
Function: GO:0000287; magnesium ion binding
GO:0002039; p53 binding
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0030275; LRR domain binding
GO:0030295; protein kinase activator activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, HSP90AA1, GSK3B, APP, SIRT1, HSPA1A, H2AFX, TP63, STUB1
- STRING interaction network
Retrieve sequences for STK11
Homologs in model organisms
- Caenorhabditis elegans
- par-4
- Danio rerio
- stk11
- Drosophila melanogaster
- lkb1
- Mus musculus
- Stk11
- Rattus norvegicus
- Stk11
- Saccharomyces cerevisiae
- SAK1
- Saccharomyces cerevisiae
- TOS3
In other databases
- GenAge model organism genes
Selected references
External links
- EPD
- ORF Accession
- NM_000455
- CDS Accession
- NP_000446
- OMIM
- 602216
- HPRD
- 03740
- Ensembl
- STK11
- UniProt/Swiss-Prot
- STK11_HUMAN
- GeneCards
- STK11
- Entrez Gene
- 6794
- GenAtlas
- STK11
- Internet
- Search Google