GenAge entry for PRKCD (Homo sapiens)
Gene name (HAGRID: 54)
- HGNC symbol
- PRKCD
- Aliases
- Common name
- protein kinase C, delta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Involved in the regulation of growth, apoptosis, and differentiation of a variety of cell types [388], PRKCD may influence age-related changes at the CNS and immune system level [387].
Cytogenetic information
- Cytogenetic band
- 3p21.31
- Location
- 53,161,207 bp to 53,192,717 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006921; cellular component disassembly involved in execution phase of apoptosis
GO:0007049; cell cycle
GO:0007165; signal transduction
GO:0007202; activation of phospholipase C activity
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010469; regulation of receptor activity
GO:0016064; immunoglobulin mediated immune response
GO:0016572; histone phosphorylation
And 41 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0016363; nuclear matrix
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004697; protein kinase C activity
GO:0004699; calcium-independent protein kinase C activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008047; enzyme activator activity
GO:0019899; enzyme binding
GO:0019900; kinase binding
GO:0019901; protein kinase binding
And 3 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TP53, STAT3, IRS1, PIK3CB, MYC, INSR, PRKCD, VCP, HSP90AA1, PDPK1, EP300, APP, YWHAZ, PTK2B, SP1, MTOR, NFE2L2, GSK3A, IKBKB, SQSTM1
- STRING interaction network
Retrieve sequences for PRKCD
Homologs in model organisms
- Caenorhabditis elegans
- tpa-1
- Danio rerio
- prkcda
- Danio rerio
- prkcdb
- Drosophila melanogaster
- Pkcdelta
- Mus musculus
- Prkcd
- Rattus norvegicus
- Prkcd
- Saccharomyces cerevisiae
- PKC1
- Schizosaccharomyces pombe
- pck1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as tpa-1
- CellAge
- This gene is present as PRKCD
Selected references
External links
- EPD
- ORF Accession
- NM_006254
- CDS Accession
- NP_006245
- OMIM
- 176977
- HPRD
- 01501
- Ensembl
- PRKCD
- UniProt/Swiss-Prot
- KPCD_HUMAN
- GeneCards
- PRKCD
- Entrez Gene
- 5580
- GenAtlas
- PRKCD
- Internet
- Search Google