GenAge entry for MXD1 (Homo sapiens)

Gene name (HAGRID: 209)

HGNC symbol: MXD1
Aliases: MAD1; bHLHc58; MAD
Common name: MAX dimerization protein 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: MXD1 is involved in apoptosis. It forms with MAX a transcriptional repressor and might antagonize MYC function [886]. There is no evidence directly linking MXD1 to human ageing.

Cytogenetic information

Cytogenetic band: 2p13-p12
Location: 69,915,041 bp to 69,942,944 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008283; cell proliferation

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, PTEN, APP, HDAC1, SIN3A, HDAC2, MAX
STRING interaction network

Retrieve sequences for MXD1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: mdl-1
Danio rerio: mxd1
Mus musculus: Mxd1
Rattus norvegicus: Mxd1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as mdl-1