GenAge entry for MXD1 (Homo sapiens)

Gene name (HAGRID: 209)

HGNC symbol
MXD1 
Aliases
MAD1; bHLHc58; MAD 
Common name
MAX dimerization protein 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

MXD1 is involved in apoptosis. It forms with MAX a transcriptional repressor and might antagonize MYC function [886]. There is no evidence directly linking MXD1 to human ageing.

Cytogenetic information

Cytogenetic band
2p13-p12
Location
69,915,041 bp to 69,942,944 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008283; cell proliferation
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0046983; protein dimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, PTEN, APP, HDAC1, SIN3A, HDAC2, MAX
STRING interaction network
Protein-Protein network diagram for MXD1

Retrieve sequences for MXD1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
mdl-1
Danio rerio
mxd1
Mus musculus
Mxd1
Rattus norvegicus
Mxd1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as mdl-1

Selected references

External links

EPD
ORF Accession
NM_002357
CDS Accession
NP_002348
OMIM
600021
HPRD
02487
Ensembl
MXD1
UniProt/Swiss-Prot
MAD1_HUMAN
GeneCards
MXD1
Entrez Gene
4084
UniGene
468908
GenAtlas
MXD1
Internet
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