GenAge entry for AIFM1 (Homo sapiens)

Gene name (HAGRID: 135)

HGNC symbol
AIFM1 
Aliases
AIF; CMTX4; PDCD8; NAMSD 
Common name
apoptosis-inducing factor, mitochondrion-associated, 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

AIFM1 is an important player in apoptosis that has been related to tumorigenesis [686]. It also appears to regulate PARP1-dependent apoptosis [415]. AIFM1 has not been directly linked to ageing.

Cytogenetic information

Cytogenetic band
Xq26.1
Location
130,129,363 bp to 130,165,887 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002931; response to ischemia
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009636; response to toxic substance
GO:0030261; chromosome condensation
GO:0043065; positive regulation of apoptotic process
GO:0043525; positive regulation of neuron apoptotic process
GO:0045454; cell redox homeostasis
GO:0051402; neuron apoptotic process
GO:0055114; oxidation-reduction process
GO:0070059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
And 8 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005758; mitochondrial intermembrane space
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm
Function: GO:0003677; DNA binding
GO:0005515; protein binding
GO:0016174; NAD(P)H oxidase activity
GO:0016651; oxidoreductase activity, acting on NAD(P)H
GO:0046983; protein dimerization activity
GO:0071949; FAD binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, EGFR, GSR, HSPA1A, BMI1, H2AFX, ESR1, MLH1
STRING interaction network
Protein-Protein network diagram for AIFM1

Retrieve sequences for AIFM1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
wah-1
Danio rerio
aifm1
Drosophila melanogaster
AIF
Mus musculus
Aifm1
Rattus norvegicus
Aifm1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as wah-1

Selected references

External links

EPD
ORF Accession
NM_004208
CDS Accession
NP_004199
OMIM
300169
HPRD
02161
Ensembl
AIFM1
UniProt/Swiss-Prot
AIFM1_HUMAN
GeneCards
AIFM1
Entrez Gene
9131
UniGene
424932
GenAtlas
AIFM1
Internet
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