GenAge entry for AIFM1 (Homo sapiens)
Gene name (HAGRID: 135)
- HGNC symbol
- AIFM1
- Aliases
- AIF; CMTX4; PDCD8; NAMSD
- Common name
- apoptosis-inducing factor, mitochondrion-associated, 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
AIFM1 is an important player in apoptosis that has been related to tumorigenesis [686]. It also appears to regulate PARP1-dependent apoptosis [415]. AIFM1 has not been directly linked to ageing.
Cytogenetic information
- Cytogenetic band
- Xq26.1
- Location
- 130,129,363 bp to 130,165,887 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0002931; response to ischemia
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009636; response to toxic substance
GO:0030261; chromosome condensation
GO:0043065; positive regulation of apoptotic process
GO:0043525; positive regulation of neuron apoptotic process
GO:0045454; cell redox homeostasis
GO:0051402; neuron apoptotic process
GO:0055114; oxidation-reduction process
GO:0070059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
And 8 more GO terms Cellular component: GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005758; mitochondrial intermembrane space
GO:0005829; cytosol
GO:0048471; perinuclear region of cytoplasm
Function: GO:0003677; DNA binding
GO:0005515; protein binding
GO:0016174; NAD(P)H oxidase activity
GO:0016651; oxidoreductase activity, acting on NAD(P)H
GO:0046983; protein dimerization activity
GO:0071949; FAD binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, EGFR, GSR, HSPA1A, BMI1, H2AFX, ESR1, MLH1
- STRING interaction network
Retrieve sequences for AIFM1
Homologs in model organisms
- Caenorhabditis elegans
- wah-1
- Danio rerio
- aifm1
- Drosophila melanogaster
- AIF
- Mus musculus
- Aifm1
- Rattus norvegicus
- Aifm1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as wah-1
Selected references
External links
- EPD
- ORF Accession
- NM_004208
- CDS Accession
- NP_004199
- OMIM
- 300169
- HPRD
- 02161
- Ensembl
- AIFM1
- UniProt/Swiss-Prot
- AIFM1_HUMAN
- GeneCards
- AIFM1
- Entrez Gene
- 9131
- GenAtlas
- AIFM1
- Internet
- Search Google