GenAge entry for TOP2B (Homo sapiens)
Gene name (HAGRID: 81)
- HGNC symbol
- TOP2B
- Aliases
- Common name
- topoisomerase (DNA) II beta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
Topoisomerases regulate the topological states of DNA [483]. Though no direct interaction has been reported, TOP2B has been indirectly linked to WRN [61] and ATM [482]. TOP2B has also been suggested as an important player in neuron proliferation [483]. Because TOP2B has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP2B is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.
Cytogenetic information
- Cytogenetic band
- 3p24
- Location
- 25,597,905 bp to 25,664,372 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000712; resolution of meiotic recombination intermediates
GO:0000819; sister chromatid segregation
GO:0001764; neuron migration
GO:0006265; DNA topological change
GO:0006268; DNA unwinding involved in DNA replication
GO:0006312; mitotic recombination
GO:0007409; axonogenesis
GO:0016925; protein sumoylation
GO:0030900; forebrain development
GO:0044774; mitotic DNA integrity checkpoint
Cellular component: GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0009295; nucleoid
GO:0009330; DNA topoisomerase complex (ATP-hydrolyzing)
Function: GO:0003682; chromatin binding
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080; protein kinase C binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008301; DNA binding, bending
GO:0019899; enzyme binding
GO:0042826; histone deacetylase binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, HDAC3, PARP1, RPA1, TOP2A, TOP1, UBE2I, PML, HDAC1, HDAC2, SUMO1, ESR1
- STRING interaction network
Retrieve sequences for TOP2B
Homologs in model organisms
- Caenorhabditis elegans
- cin-4
- Caenorhabditis elegans
- top-2
- Danio rerio
- top2b
- Drosophila melanogaster
- Top2
- Mus musculus
- Top2b
- Saccharomyces cerevisiae
- TOP2
- Schizosaccharomyces pombe
- top2
Selected references
External links
- EPD
- ORF Accession
- NM_001068
- CDS Accession
- NP_001059
- OMIM
- 126431
- HPRD
- 00537
- Ensembl
- TOP2B
- UniProt/Swiss-Prot
- TOP2B_HUMAN
- GeneCards
- TOP2B
- Entrez Gene
- 7155
- GenAtlas
- TOP2B
- Internet
- Search Google