GenAge entry for TOP2B (Homo sapiens)

Gene name (HAGRID: 81)

HGNC symbol
TOP2B 
Aliases
 
Common name
topoisomerase (DNA) II beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Topoisomerases regulate the topological states of DNA [483]. Though no direct interaction has been reported, TOP2B has been indirectly linked to WRN [61] and ATM [482]. TOP2B has also been suggested as an important player in neuron proliferation [483]. Because TOP2B has been associated with several DNA metabolism proteins thought to play a role in ageing, it is possible that TOP2B is itself involved in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band
3p24
Location
25,597,905 bp to 25,664,372 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000712; resolution of meiotic recombination intermediates
GO:0000819; sister chromatid segregation
GO:0001764; neuron migration
GO:0006265; DNA topological change
GO:0006268; DNA unwinding involved in DNA replication
GO:0006312; mitotic recombination
GO:0007409; axonogenesis
GO:0016925; protein sumoylation
GO:0030900; forebrain development
GO:0044774; mitotic DNA integrity checkpoint
Cellular component: GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0009295; nucleoid
GO:0009330; DNA topoisomerase complex (ATP-hydrolyzing)
Function: GO:0003682; chromatin binding
GO:0003918; DNA topoisomerase type II (ATP-hydrolyzing) activity
GO:0005080; protein kinase C binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008301; DNA binding, bending
GO:0019899; enzyme binding
GO:0042826; histone deacetylase binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, HDAC3, PARP1, RPA1, TOP2A, TOP1, UBE2I, PML, HDAC1, HDAC2, SUMO1, ESR1
STRING interaction network
Protein-Protein network diagram for TOP2B

Retrieve sequences for TOP2B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cin-4
Caenorhabditis elegans
top-2
Danio rerio
top2b
Drosophila melanogaster
Top2
Mus musculus
Top2b
Saccharomyces cerevisiae
TOP2
Schizosaccharomyces pombe
top2

Selected references

External links

EPD
ORF Accession
NM_001068
CDS Accession
NP_001059
OMIM
126431
HPRD
00537
Ensembl
TOP2B
UniProt/Swiss-Prot
TOP2B_HUMAN
GeneCards
TOP2B
Entrez Gene
7155
UniGene
475733
GenAtlas
TOP2B
Internet
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