GenAge entry for AGPAT2 (Homo sapiens)

Gene name (HAGRID: 187)

HGNC symbol
AGPAT2 
Aliases
LPAAT-beta; BSCL 
Common name
1-acylglycerol-3-phosphate O-acyltransferase 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

AGPAT2 is a phospholipid with diverse biologic activities. Mutations in the human AGPAT2 gene have been associated with Bernardinelli-Seip congenital lipodystrophy, a possible segmental progeroid syndrome [151].

Cytogenetic information

Cytogenetic band
9q34.3
Location
136,673,143 bp to 136,687,459 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001819; positive regulation of cytokine production
GO:0001961; positive regulation of cytokine-mediated signaling pathway
GO:0006644; phospholipid metabolic process
GO:0006654; phosphatidic acid biosynthetic process
GO:0008544; epidermis development
GO:0016024; CDP-diacylglycerol biosynthetic process
GO:0019432; triglyceride biosynthetic process
GO:0042493; response to drug
Cellular component: GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral component of membrane
Function: GO:0003841; 1-acylglycerol-3-phosphate O-acyltransferase activity
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for AGPAT2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
acl-1
Caenorhabditis elegans
acl-2
Danio rerio
agpat2
Drosophila melanogaster
fu12
Drosophila melanogaster
CG3812
Mus musculus
Agpat2
Rattus norvegicus
Agpat2
Saccharomyces cerevisiae
SLC1

Selected references

External links

EPD
ORF Accession
NM_006412
CDS Accession
NP_006403
OMIM
603100
HPRD
04373
Ensembl
AGPAT2
UniProt/Swiss-Prot
PLCB_HUMAN
GeneCards
AGPAT2
Entrez Gene
10555
UniGene
320151
GenAtlas
AGPAT2
Internet
Search Google