GenAge entry for FOXM1 (Homo sapiens)
Gene name (HAGRID: 131)
- HGNC symbol
- FOXM1
- Aliases
- HFH-11; trident; HNF-3; INS-1; MPP2; MPHOSPH2; TGT3; FKHL16
- Common name
- forkhead box M1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
A transcriptional regulator that is important in development, FOXM1 may also play a role in cell proliferation. In invertebrates, such as roundworms, the forkhead family has been linked to ageing [957]. In mice, FOXM1 has been associated with GH1-stimulated liver regeneration. Increased expression of FOXM1 in old mice restored hepatocyte proliferation to levels found in young animals [276]. It remains to be determined whether FOXM1 is involved in human ageing.
Cytogenetic information
- Cytogenetic band
- 12p13
- Location
- 2,857,681 bp to 2,877,155 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006281; DNA repair
GO:0006351; transcription, DNA-templated
GO:0006978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008284; positive regulation of cell proliferation
GO:0032873; negative regulation of stress-activated MAPK cascade
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046578; regulation of Ras protein signal transduction
And 6 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
Function: GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0019901; protein kinase binding
GO:0043565; sequence-specific DNA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- CREBBP, HSP90AA1, UBE2I, GSK3B, TERF1, RB1, SP1, CDK1, SUMO1, CTNNB1, CHEK2, GSK3A
- STRING interaction network
Retrieve sequences for FOXM1
Homologs in model organisms
- Caenorhabditis elegans
- fkh-9
- Danio rerio
- foxm1
- Mus musculus
- Foxm1
- Rattus norvegicus
- Foxm1
- Saccharomyces cerevisiae
- HCM1
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as FOXM1
- CellAge gene expression
- This gene is present as FOXM1
Selected references
External links
- EPD
- ORF Accession
- NM_021953
- CDS Accession
- NP_068772
- OMIM
- 602341
- HPRD
- 03823
- Ensembl
- FOXM1
- UniProt/Swiss-Prot
- FOXM1_HUMAN
- GeneCards
- FOXM1
- Entrez Gene
- 2305
- GenAtlas
- FOXM1
- Internet
- Search Google