GenAge entry for POLA1 (Homo sapiens)
Gene name (HAGRID: 204)
- HGNC symbol
- POLA1
- Aliases
- p180; POLA; NSX
- Common name
- polymerase (DNA directed), alpha 1, catalytic subunit
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
POLA1 is involved in DNA replication. In yeast, mutations in POLA1 reduce lifespan [1425]. Age-related changes in POLA1 induction have been shown in rats [580]. Whether POLA1 is involved in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- Xp22.1-p21
- Location
- 24,693,947 bp to 24,996,985 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000722; telomere maintenance via recombination
GO:0000731; DNA synthesis involved in DNA repair
GO:0006260; DNA replication
GO:0006269; DNA replication, synthesis of RNA primer
GO:0006270; DNA replication initiation
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006272; leading strand elongation
GO:0006273; lagging strand elongation
GO:0006281; DNA repair
And 5 more GO terms Cellular component: GO:0000785; chromatin
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005658; alpha DNA polymerase:primase complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0016363; nuclear matrix
Function: GO:0000166; nucleotide binding
GO:0001882; nucleoside binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0003896; DNA primase activity
GO:0005515; protein binding
GO:0008408; 3'-5' exonuclease activity
GO:0019901; protein kinase binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
And 2 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, MYC, PARP1, RPA1, XRCC5, PCNA, RB1, CCNA2, CDK1, RAE1, SIRT7
- STRING interaction network
Retrieve sequences for POLA1
Homologs in model organisms
- Caenorhabditis elegans
- Y47D3A.29
- Danio rerio
- pola1
- Drosophila melanogaster
- DNApol-alpha180
- Mus musculus
- Pola1
- Rattus norvegicus
- Pola1
- Saccharomyces cerevisiae
- POL1
- Schizosaccharomyces pombe
- pol1
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as Y47D3A.29
- CellAge gene expression
- This gene is present as POLA1
Selected references
External links
- EPD
- ORF Accession
- NM_016937
- CDS Accession
- NP_058633
- OMIM
- 312040
- HPRD
- 02416
- Ensembl
- POLA1
- UniProt/Swiss-Prot
- DPOLA_HUMAN
- GeneCards
- POLA1
- Entrez Gene
- 5422
- GenAtlas
- POLA1
- Internet
- Search Google