GenAge entry for CSNK1E (Homo sapiens)

Gene name (HAGRID: 244)

HGNC symbol
CSNK1E 
Aliases
HCKIE; CKIE; CKIepsilon 
Common name
casein kinase 1, epsilon 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

CSNK1E is a member of the serine/threonine protein kinase family. It can phosphorylate a number of proteins, including circadian rhythm proteins, meaning it may be involved in many processes.

The tau mutation in CSNK1E is a semidominant autosomal allele that shortens the length of circadian rhythms in Syrian hamsters [1831]. It also increases metabolic rate [1835]. In these animals, this mutation decreases longevity under normal conditions [1833], but if animals are kept in darkness and under constant temperature lifespan is extended 14-16% [1426], though it is not clear ageing is delayed.

Cytogenetic information

Cytogenetic band
22q13.1
Location
38,290,691 bp to 38,318,084 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000086; G2/M transition of mitotic cell cycle
GO:0006281; DNA repair
GO:0006364; rRNA processing
GO:0006468; protein phosphorylation
GO:0006897; endocytosis
GO:0007165; signal transduction
GO:0008360; regulation of cell shape
GO:0016055; Wnt signaling pathway
GO:0018105; peptidyl-serine phosphorylation
GO:0030178; negative regulation of Wnt signaling pathway
GO:0032091; negative regulation of protein binding
And 12 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0030426; growth cone
GO:0030529; intracellular ribonucleoprotein complex
GO:0043025; neuronal cell body
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0044822; poly(A) RNA binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, MYC, APP, PCMT1, MAPK9, PPP1CA, CSNK1E, ARNTL, CLOCK
STRING interaction network
Protein-Protein network diagram for CSNK1E

Retrieve sequences for CSNK1E

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
kin-20
Danio rerio
csnk1e
Drosophila melanogaster
dco
Mus musculus
Csnk1e
Rattus norvegicus
Csnk1e
Saccharomyces cerevisiae
HRR25

Selected references

External links

EPD
ORF Accession
NM_001894
CDS Accession
NP_001885
OMIM
600863
HPRD
02919
Ensembl
CSNK1E
UniProt/Swiss-Prot
KC1E_HUMAN
GeneCards
CSNK1E
Entrez Gene
1454
UniGene
474833
GenAtlas
CSNK1E
Internet
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