GenAge entry for CISD2 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 265)
- HGNC symbol
- CISD2
- Aliases
- Miner1; ERIS; NAF-1; ZCD2; WFS2
- Common name
- CDGSH iron sulfur domain 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
Knockout mice for CISD2, the causative gene in Wolfram syndrome 2, show an increased mitochondrial breakdown and dysfunction accompanied by autophagic cell death. Mice exhibit multiple signs of premature aging: prominent eyes and protruding ears, ocular abnormalities, early depigmentation of the fur, hair follicle atrophy, decreased hair density and regrowth rate, thickened dermis, significant decrease in subcutaneous adipose tissue and muscle, muscle atrophy, osteroporosis, decrease in pulmonary capacity, and have a shorter lifespan [2153]. In wild type, the expression levels of CISD2 decrease with age [2154]. Transgenic expression in mice extend lifespan [3315]. As such, CISD2 is a strong candidate for a role in ageing, though further human studies are warranted.
Cytogenetic information
- Cytogenetic band
- 4q24
- Location
- 102,868,978 bp to 102,892,806 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000422; mitophagy
GO:0010259; multicellular organism aging
GO:0010506; regulation of autophagy
Cellular component: GO:0005741; mitochondrial outer membrane
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0016020; membrane
GO:0016021; integral component of membrane
GO:0043234; protein complex
Function: GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0044822; poly(A) RNA binding
GO:0046872; metal ion binding
GO:0051537; 2 iron, 2 sulfur cluster binding
Protein interactions and network
Retrieve sequences for CISD2
Homologs in model organisms
- Caenorhabditis elegans
- cisd-1
- Danio rerio
- cisd2
- Drosophila melanogaster
- Cisd2
- Mus musculus
- Cisd2
- Rattus norvegicus
- Cisd2
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Cisd2
Selected references
External links
- EPD
- ORF Accession
- NM_001008388
- CDS Accession
- NP_001008389
- OMIM
- 611507
- HPRD
- 17413
- Ensembl
- CISD2
- UniProt/Swiss-Prot
- CISD2_HUMAN
- GeneCards
- CISD2
- Entrez Gene
- 493856
- GenAtlas
- CISD2
- Internet
- Search Google