GenAge entry for MYC (Homo sapiens)

Gene name (HAGRID: 39)

HGNC symbol
MYC 
Aliases
c-Myc; bHLHe39; MYCC 
Common name
v-myc avian myelocytomatosis viral oncogene homolog 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

MYC regulates gene transcription and appears to promote growth. It is also an oncogene [226], involved in cellular senescence [1617]. Overexpression of Myc in flies increases the frequency of somatic mutations, and shortens median and maximum lifespan by up to 47%. Contrastly, Myc haploinsufficiency lowers the frequency of somatic mutations and extends the lifespan of flies by about 14% [3543]. Among its many interacting partners, MYC has been linked to ageing-related genes such as WRN [223] and TERT [225], and hence might play some, so far unknown, role in human ageing.

Cytogenetic information

Cytogenetic band
8q24.21
Location
127,736,069 bp to 127,741,434 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0001658; branching involved in ureteric bud morphogenesis
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0006112; energy reserve metabolic process
GO:0006338; chromatin remodeling
GO:0006366; transcription from RNA polymerase II promoter
GO:0006879; cellular iron ion homeostasis
GO:0006974; cellular response to DNA damage stimulus
GO:0007050; cell cycle arrest
GO:0007219; Notch signaling pathway
And 29 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005829; cytosol
GO:0043234; protein complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0032403; protein complex binding
GO:0046983; protein dimerization activity
GO:0070491; repressing transcription factor binding
GO:0070888; E-box binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, PLAU, LMNA, TXN, IRS2, MYC, PRKCD, HDAC3, BRCA1, PIN1, CREBBP, HIF1A, NCOR1, BCL2, HSP90AA1, TOP2A, TOP1, UBE2I, EP300, PML, GSK3B, ERCC3, PRKDC, XRCC5, POLD1, XRCC6, RB1, FOXO3, APP, PRDX1, SIRT1, HDAC1, HSPD1, HSPA1A, MAPK8, SP1, JUN, MED1, MAPK3, TFAP2A, TBP, HBP1, HDAC2, MAX, TAF1, POLA1, RELA, HELLS, CEBPA, CEBPB, ESR1, CDKN2A, PPP1CA, MLH1, CSNK1E, STUB1, TP73, NFE2L2, GSK3A, SQSTM1
STRING interaction network
Protein-Protein network diagram for MYC

Retrieve sequences for MYC

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
mycb
Danio rerio
myca
Drosophila melanogaster
dm
Mus musculus
Myc
Rattus norvegicus
Myc

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Myc
  • A homolog of this gene for Drosophila melanogaster is present as dm
CellAge
  • This gene is present as MYC

Selected references

External links

EPD
HS_MYC_2
ORF Accession
NM_002467
CDS Accession
NP_002458
OMIM
190080
HPRD
01818
Ensembl
MYC
UniProt/Swiss-Prot
MYC_HUMAN
GeneCards
MYC
Entrez Gene
4609
UniGene
202453
GenAtlas
MYC
Internet
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