Cell Senescence Entries for MYC

Cell Types
Fibroblast
Cell Lines
LF1
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
Knockdown of c-Myc (MYC) signalling in human diploid fibroblats (HDFs) was found to trigger telomere-independent senescence. This process was mediated by cyclin-dependent kinase inhibitor p16, a common marker of senescence.
Primary Reference

    MYC Gene Information

    HGNC symbol
    MYC 
    Aliases
    MRTL; MYCC; c-Myc; bHLHe39 
    Common name
    MYC proto-oncogene, bHLH transcription factor 
    Entrez Id
    4609
    Description
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

    MYC Ontologies

    Gene Ontology
    Process: GO:70371; ERK1 and ERK2 cascade
    GO:82; G1/S transition of mitotic cell cycle
    GO:165; MAPK cascade
    GO:7219; Notch signaling pathway
    GO:1904837; beta-catenin-TCF complex assembly
    GO:1658; branching involved in ureteric bud morphogenesis
    GO:60070; canonical Wnt signaling pathway
    GO:7050; cell cycle arrest
    GO:6879; cellular iron ion homeostasis
    GO:6974; cellular response to DNA damage stimulus
    GO:34644; cellular response to UV
    And 35 more GO terms
    Cellular component: GO:5829; cytosol
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:3677; DNA binding
    GO:70888; E-box binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:33613; activating transcription factor binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:46983; protein dimerization activity
    GO:70491; repressing transcription factor binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    And 1 more GO terms
    Show all GO terms

    Homologs of MYC in Model Organisms

    Danio rerio
    mycb
    Danio rerio
    myca
    Drosophila melanogaster
    dm
    Mus musculus
    Myc
    Rattus norvegicus
    Myc

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Myc
    • A homolog of this gene for Drosophila melanogaster is present as dm
    GenAge human genes
    • This gene is present as MYC

    External links

    OMIM
    190080
    Ensembl
    ENSG00000136997
    Entrez Gene
    4609
    UniGene
    202453
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MYC
    GeneCards
    MYC