Cell Senescence Entries for MYC
- Cell Types
- Fibroblast
- Cell Lines
- LF1
- Cancer Cell?
- No
- Method
- Knockout
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Observations
- Knockdown of c-Myc (MYC) signalling in human diploid fibroblats (HDFs) was found to trigger telomere-independent senescence. This process was mediated by cyclin-dependent kinase inhibitor p16, a common marker of senescence.
- Primary Reference
MYC Gene Information
- HGNC symbol
- MYC
- Aliases
- MRTL; MYCC; c-Myc; bHLHe39
- Common name
- MYC proto-oncogene, bHLH transcription factor
- Entrez Id
- 4609
- Description
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
MYC Ontologies
- Gene Ontology
-
Process: GO:70371; ERK1 and ERK2 cascade
GO:82; G1/S transition of mitotic cell cycle
GO:165; MAPK cascade
GO:7219; Notch signaling pathway
GO:1904837; beta-catenin-TCF complex assembly
GO:1658; branching involved in ureteric bud morphogenesis
GO:60070; canonical Wnt signaling pathway
GO:7050; cell cycle arrest
GO:6879; cellular iron ion homeostasis
GO:6974; cellular response to DNA damage stimulus
GO:34644; cellular response to UV
And 35 more GO terms Cellular component: GO:5829; cytosol
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5634; nucleus
GO:43234; protein complex
Function: GO:3677; DNA binding
GO:70888; E-box binding
GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:33613; activating transcription factor binding
GO:5515; protein binding
GO:32403; protein complex binding
GO:46983; protein dimerization activity
GO:70491; repressing transcription factor binding
GO:3700; transcription factor activity, sequence-specific DNA binding
GO:8134; transcription factor binding
GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
And 1 more GO terms
Homologs of MYC in Model Organisms
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as MYC
External links
- OMIM
- 190080
- Ensembl
- ENSG00000136997
- Entrez Gene
- 4609
- UniGene
- 202453
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MYC
- GeneCards
- MYC