GenAge entry for PARP1 (Homo sapiens)

Gene name (HAGRID: 60)

HGNC symbol
PARP1 
Aliases
PARP; PPOL; ADPRT 
Common name
poly (ADP-ribose) polymerase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

The PARP1 enzyme catalyses the transfer of ADP-ribose to a variety of nuclear proteins including members of the high mobility group box and topoisomerase families [984]. It is involved in a variety of processes such as proliferation, differentiation, and recovery from DNA damage [407]. PARP1's levels appear to inversely correlate with mammalian lifespan and PARP1 has been hinted as a determinant of mammalian ageing [68]. PARP1 is a critical mediator of axon growth inhibition. Pharmacological inhibition or genetic loss of PARP1in mouse cells markedly facilitates axon regeneration, thus making PARP1 a potential target to reverse neurological disability [4346]. Nonetheless, more detailed studies are necessary to investigate a role for PARP1 in ageing.

Cytogenetic information

Cytogenetic band
1q41-q42
Location
226,360,691 bp to 226,408,100 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000715; nucleotide-excision repair, DNA damage recognition
GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0000724; double-strand break repair via homologous recombination
GO:0006273; lagging strand elongation
GO:0006281; DNA repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006302; double-strand break repair
And 39 more GO terms
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005739; mitochondrion
GO:0016020; membrane
GO:0043234; protein complex
Function: GO:0003677; DNA binding
GO:0003910; DNA ligase (ATP) activity
GO:0003950; NAD+ ADP-ribosyltransferase activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0030331; estrogen receptor binding
GO:0042802; identical protein binding
GO:0042826; histone deacetylase binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, WRN, LMNA, HDAC3, PARP1, BRCA1, CREBBP, HIF1A, RPA1, BLM, BCL2, ABL1, TOP2B, NFKB1, TOP1, UBE2I, ERCC6, EP300, PRKDC, XRCC5, PCNA, XRCC6, FOXO1, SIRT1, HDAC1, PTK2, SP1, JUN, MED1, BMI1, E2F1, HDAC2, POLA1, RELA, TCF3, H2AFX, HOXB7, BUB1B, APTX, CEBPA, ESR1, CTNNB1, POLB, BUB3, CDKN1A
STRING interaction network
Protein-Protein network diagram for PARP1

Retrieve sequences for PARP1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pme-1
Danio rerio
parp1
Drosophila melanogaster
Parp
Mus musculus
Parp1
Rattus norvegicus
Parp1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as pme-1
LongevityMap
  • This gene is present as PARP1

Selected references

External links

EPD
HS_ADPRT
ORF Accession
NM_001618
CDS Accession
NP_001609
OMIM
173870
HPRD
01435
Ensembl
PARP1
UniProt/Swiss-Prot
PARP1_HUMAN
GeneCards
PARP1
Entrez Gene
142
UniGene
177766
GenAtlas
PARP1
Internet
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