Caenorhabditis elegansGenAge entry for pme-1 (Caenorhabditis elegans)

Gene information (ID: 1757)

Symbol
pme-1
Name
Protein PME-1
Organism
Caenorhabditis elegans (AnAge)

Potential relevance to longevity and/or ageing

Observations
pme-1 mutant worms show a 29% mean lifespan extension, whereas RNAi of pme-1 extends lifespan by 20%. PARP inhibition by either AZD2281 or ABT-888 also extends worm lifespan by up to 23%, and does not further extend the lifespan of pme-1 mutants.
% change in avg or median lifespan
Lifespan is up to 29% higher.
Lifespan Effect
Increase
Genetic Manipulation
RNA interference and/or mutations
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as PARP1
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as PARP1

    Homologs in other organisms

    Danio rerio
    parp1
    Drosophila melanogaster
    Parp
    Homo sapiens
    PARP1
    Mus musculus
    Parp1
    Rattus norvegicus
    Parp1

    External links

    WormBase
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (266823)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar