GenAge entry for SP1 (Homo sapiens)

Gene name (HAGRID: 170)

HGNC symbol: SP1
Aliases
Common name: Sp1 transcription factor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: An important transcription factor, SP1 is involved in the regulation of many genes, including ageing-related genes such as WRN [819] or cellular senescence-related genes like CDKN2A [3616]. Some results have linked SP1 disruption to Huntington's disease [534]. SP1 was shown to be dowregulated in cellular senescence, and under DNA damage signaling regulation [3667]. SP1 is involved in so many processes that it is possible for SP1 to play some role in human ageing.

Cytogenetic information

Cytogenetic band: 12q13.1
Location: 53,380,195 bp to 53,416,442 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006355; regulation of transcription, DNA-templated
GO:0016032; viral process
GO:0032869; cellular response to insulin stimulus
GO:0042795; snRNA transcription from RNA polymerase II promoter
GO:0043923; positive regulation by host of viral transcription
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048511; rhythmic process
GO:0100057; regulation of phenotypic switching by transcription from RNA polymerase II promoter
GO:1904828; positive regulation of hydrogen sulfide biosynthetic process

Cellular component:

GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0032993; protein-DNA complex

Function:

GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001046; core promoter sequence-specific DNA binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0003677; DNA binding
GO:0003690; double-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0008134; transcription factor binding

And 9 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, E2F1, NFKB2, STAT3, HDAC3, MYC, NCOR1, PRKCD, PARP1, BRCA1, PIN1, CREBBP, HIF1A, HSP90AA1, EGR1, BRCA2, NFKB1, RAD51, CEBPB, EP300, PML, HTT, PRKDC, AR, RB1, FOXM1, RELA, HDAC1, HSPA9, MAPK8, MAPK14, SP1, JUN, MAPK3, CCNA2, TFAP2A, TBP, SIN3A, CDK1, HDAC2, ESR1, CTNNB1, CDKN2A, DBN1, HIC1, PPARG, NCOR2
STRING interaction network

Retrieve sequences for SP1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: sptf-2
Danio rerio: sp1
Drosophila melanogaster: Spps
Mus musculus: Sp1
Rattus norvegicus: Sp1

In other databases

CellAge

This gene is present as SP1