Cell Senescence Entries for SP1

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of SP1 induced p16 promoter activity and increased SA-beta-galactosidase activity. In contrast, knock-down of SP1 lead to reduced SA-beta-galactosidase staining.
Primary Reference

    SP1 Gene Information

    HGNC symbol
    SP1 
    Aliases
     
    Common name
    Sp1 transcription factor 
    Entrez Id
    6667
    Description
    The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

    SP1 Ontologies

    Gene Ontology
    Process: GO:32869; cellular response to insulin stimulus
    GO:43923; positive regulation by host of viral transcription
    GO:1904828; positive regulation of hydrogen sulfide biosynthetic process
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:45893; positive regulation of transcription, DNA-templated
    GO:100057; regulation of phenotypic switching by transcription from RNA polymerase II promoter
    GO:6355; regulation of transcription, DNA-templated
    GO:48511; rhythmic process
    GO:42795; snRNA transcription from RNA polymerase II promoter
    GO:16032; viral process
    Cellular component: GO:5737; cytoplasm
    GO:790; nuclear chromatin
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:32993; protein-DNA complex
    GO:17053; transcriptional repressor complex
    Function: GO:3677; DNA binding
    GO:71837; HMG box domain binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
    GO:1103; RNA polymerase II repressing transcription factor binding
    GO:43425; bHLH transcription factor binding
    GO:1046; core promoter sequence-specific DNA binding
    GO:3690; double-stranded DNA binding
    GO:35035; histone acetyltransferase binding
    GO:42826; histone deacetylase binding
    GO:46872; metal ion binding
    And 11 more GO terms
    Show all GO terms

    Homologs of SP1 in Model Organisms

    Danio rerio
    sp1
    Mus musculus
    Sp1
    Rattus norvegicus
    Sp1

    In other databases

    GenAge human genes
    • This gene is present as SP1

    External links

    OMIM
    189906
    Ensembl
    ENSG00000185591
    Entrez Gene
    6667
    UniGene
    620754
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SP1
    GeneCards
    SP1