Drosophila melanogasterGenAge entry for Mpk2 (Drosophila melanogaster)

Gene information (ID: 1832)

Symbol
Mpk2
Aliases
CG5475; D-MPK2; D-p38; D-p38; MAPK; D-p38a; D-P38a; Dmel\
Name
CG5475-PA
Organism
Drosophila melanogaster (AnAge)

Potential relevance to longevity and/or ageing

Observations
p38K-DKO adult flies appeared normal on eclosion but had a severely reduced lifespan. ingle mutants of p38Ka (p38Kadel) or p38Kb (p38Kd45) also had significantly reduced lifespan, with the loss of p38Kb resulting in a stronger phenotype.
% change in avg or median lifespan
Average lifespan is 40% lower.
Lifespan Effect
Decrease
Genetic Manipulation
Mutation
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as MAPK14
    GenDR gene manipulations
    • A homolog of this gene for Schizosaccharomyces pombe is present as sty1
    CellAge
    • A homolog of this gene for Homo sapiens is present as MAPK12
    • A homolog of this gene for Homo sapiens is present as MAPK14

    Homologs in other organisms

    Caenorhabditis elegans
    pmk-1
    Caenorhabditis elegans
    pmk-2
    Danio rerio
    mapk14b
    Danio rerio
    mapk11
    Danio rerio
    mapk12b
    Danio rerio
    mapk13
    Danio rerio
    zgc:171775
    Danio rerio
    mapk12a
    Danio rerio
    mapk14a
    Homo sapiens
    MAPK12
    Homo sapiens
    MAPK13
    Homo sapiens
    MAPK14
    Homo sapiens
    MAPK11
    Mus musculus
    Mapk13
    Mus musculus
    Mapk11
    Mus musculus
    Mapk12
    Mus musculus
    Mapk14
    Rattus norvegicus
    Mapk12
    Rattus norvegicus
    Mapk13
    Rattus norvegicus
    Mapk14
    Rattus norvegicus
    Mapk11
    Saccharomyces cerevisiae
    HOG1
    Schizosaccharomyces pombe
    sty1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (42866)
    Homologues
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    UniProt
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    Internet
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