Cell Senescence Entries for MAPK14
- Cell Types
- Lung fibroblast
- Cell Lines
- MRC-5, WI-38
- Cancer Cell?
- No
- Method
- Knockout
- Type of senescence
- Replicative, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Iwasa et al. (2003) Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8(2)131-44 (PubMed)
MAPK14 Gene Information
- HGNC symbol
- MAPK14
- Aliases
- CSBP1; CSBP2; CSPB1; Mxi2; p38; PRKM14; PRKM15
- Common name
- mitogen-activated protein kinase 14
- Entrez Id
- 1432
- Description
- The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
MAPK14 Ontologies
- Gene Ontology
-
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:165; MAPK cascade
GO:6915; apoptotic process
GO:6357; regulation of transcription by RNA polymerase II
GO:38066; p38MAPK cascade
GO:35556; intracellular signal transduction
GO:98586; cellular response to virus
GO:10628; positive regulation of gene expression
GO:6935; chemotaxis
GO:7165; signal transduction
And 55 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16607; nuclear speck
GO:5829; cytosol
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:922; spindle pole
GO:5739; mitochondrion
GO:98978; glutamatergic synapse
And 1 more GO terms Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4707; MAP kinase activity
GO:5515; protein binding
GO:19903; protein phosphatase binding
And 5 more GO terms
Homologs of MAPK14 in Model Organisms
- Caenorhabditis elegans
- pmk-2
- Caenorhabditis elegans
- pmk-1
- Danio rerio
- mapk14b
- Danio rerio
- mapk14a
- Drosophila melanogaster
- p38b
- Drosophila melanogaster
- p38a
- Drosophila melanogaster
- p38c
- Mus musculus
- Mapk14
- Rattus norvegicus
- Mapk14
- Saccharomyces cerevisiae
- HOG1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as MAPK14
External links
- OMIM
- 600289
- Ensembl
- ENSG00000112062
- Entrez Gene
- 1432
- UniGene
- 485233
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MAPK14
- GeneCards
- MAPK14