GenAge entry for PRKCA (Homo sapiens)

Gene name (HAGRID: 99)

HGNC symbol
PRKCA 
Aliases
PKCA 
Common name
protein kinase C, alpha 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PRKCA is a phorbol ester receptor involved in signal transduction. It appears to interact with many proteins, including some that have been related to ageing, such as LMNA and INSR. In the medfly, PRKCA levels are age-dependent [535]. PRKCA has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
17q22-q23.
Location
66,302,808 bp to 66,810,744 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001525; angiogenesis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0002159; desmosome assembly
GO:0006468; protein phosphorylation
GO:0007077; mitotic nuclear envelope disassembly
GO:0007155; cell adhesion
GO:0007190; activation of adenylate cyclase activity
GO:0007194; negative regulation of adenylate cyclase activity
GO:0010595; positive regulation of endothelial cell migration
GO:0010613; positive regulation of cardiac muscle hypertrophy
GO:0018105; peptidyl-serine phosphorylation
And 19 more GO terms
Cellular component: GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031966; mitochondrial membrane
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
Function: GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004697; protein kinase C activity
GO:0004698; calcium-dependent protein kinase C activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008270; zinc ion binding
GO:0019899; enzyme binding
GO:0035403; histone kinase activity (H3-T6 specific)
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
LMNA, EGFR, PLCG2, HSP90AA1, TOP2A, EP300, GSK3B, PRKCA, FAS, YWHAZ, LMNB1, NFKBIA, MTOR, CTNNB1, CDKN2A, PPARG, NFE2L2, GSK3A, IKBKB, RICTOR
STRING interaction network
Protein-Protein network diagram for PRKCA

Retrieve sequences for PRKCA

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pkc-2
Danio rerio
prkca
Danio rerio
PRKCA (1 of many)
Drosophila melanogaster
Pkc53E
Drosophila melanogaster
inaC
Mus musculus
Prkca
Rattus norvegicus
Prkca
Saccharomyces cerevisiae
PKC1

In other databases

LongevityMap
  • This gene is present as PRKCA

Selected references

External links

EPD
ORF Accession
NM_002737
CDS Accession
NP_002728
OMIM
176960
HPRD
01498
Ensembl
PRKCA
UniProt/Swiss-Prot
KPCA_HUMAN
GeneCards
PRKCA
Entrez Gene
5578
GenAtlas
PRKCA
Internet
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