GenAge entry for VCP (Homo sapiens)
Gene name (HAGRID: 71)
- HGNC symbol
- VCP
- Aliases
- IBMPFD; p97
- Common name
- valosin containing protein
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Also known as p97, VCP is required for the export of endoplasmic reticulum proteins into the cytosol [455]. Its interaction with WRN and a possible role in WRN's DNA damage response pathway makes it an intriguing protein [454], even though it has not been directly linked to ageing.
Cytogenetic information
- Cytogenetic band
- 9p13.3
- Location
- 35,056,068 bp to 35,072,742 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006281; DNA repair
GO:0006302; double-strand break repair
GO:0006734; NADH metabolic process
GO:0006888; ER to Golgi vesicle-mediated transport
GO:0006914; autophagy
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974; cellular response to DNA damage stimulus
GO:0010918; positive regulation of mitochondrial membrane potential
GO:0016567; protein ubiquitination
GO:0018279; protein N-linked glycosylation via asparagine
GO:0019079; viral genome replication
And 26 more GO terms Cellular component: GO:0000502; proteasome complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005811; lipid particle
GO:0005829; cytosol
GO:0034098; VCP-NPL4-UFD1 AAA ATPase complex
GO:0035861; site of double-strand break
GO:0036513; Derlin-1 retrotranslocation complex
And 6 more GO terms Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008289; lipid binding
GO:0016887; ATPase activity
GO:0019903; protein phosphatase binding
GO:0019904; protein domain specific binding
GO:0031593; polyubiquitin binding
GO:0031625; ubiquitin protein ligase binding
GO:0035800; deubiquitinase activator activity
GO:0036435; K48-linked polyubiquitin binding
GO:0042288; MHC class I protein binding
And 7 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ERCC8, WRN, LMNA, NFKB2, AKT1, PRKCD, BRCA1, HIF1A, UBB, BLM, VCP, HSP90AA1, NFKB1, TOP1, ERCC6, HTT, HELLS, AR, TERF2, BAX, GRB2, HSPD1, HSPA1A, YWHAZ, MAPK3, PTGS2, HSPA8, CDK1, MDM2, SUMO1, ESR1, NFKBIA, MTOR, TP63, STUB1, CHEK2, SIRT7, TP53BP1, CDKN1A, HTRA2, SPRTN
- STRING interaction network
Retrieve sequences for VCP
Homologs in model organisms
- Caenorhabditis elegans
- cdc-48.1
- Caenorhabditis elegans
- cdc-48.2
- Danio rerio
- vcp
- Drosophila melanogaster
- TER94
- Mus musculus
- Vcp
- Rattus norvegicus
- Vcp
- Saccharomyces cerevisiae
- CDC48
- Schizosaccharomyces pombe
- cdc48
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as cdc-48.1