GenAge entry for YWHAZ (Homo sapiens)
Gene name (HAGRID: 164)
- HGNC symbol
- YWHAZ
- Aliases
- KCIP-1; 14-3-3-zeta; YWHAD
- Common name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
YWHAZ is an adapter protein implicated in several signal transduction pathways [997]. Although YWHAZ has not been directly related to ageing, because it interacts with so many proteins, including many associated with ageing such as the INS/IGF1 pathway [996], it is possible that YWHAZ itself plays some role in human ageing.
Cytogenetic information
- Cytogenetic band
- 8q23.1
- Location
- 100,918,576 bp to 100,952,129 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0007165; signal transduction
GO:0030168; platelet activation
GO:0043066; negative regulation of apoptotic process
GO:0043488; regulation of mRNA stability
GO:0051683; establishment of Golgi localization
GO:0061024; membrane organization
GO:0090168; Golgi reassembly
GO:0098609; cell-cell adhesion
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0005925; focal adhesion
GO:0030659; cytoplasmic vesicle membrane
GO:0042470; melanosome
GO:0070062; extracellular exosome
And 2 more GO terms Function: GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
GO:0019904; protein domain specific binding
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0044822; poly(A) RNA binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, TERT, IRS2, AKT1, EGFR, NCOR1, PRKCD, BRCA1, VCP, ABL1, EP300, PRKCA, XRCC6, GRB2, FOXO3, FOXO1, APP, RAD52, HSPA1B, MAPK8, YWHAZ, MAP3K5, MAPT, H2AFX, MTOR, CTNNB1, UCP3, UCP2, TP53BP1, SQSTM1
- STRING interaction network
Retrieve sequences for YWHAZ
Homologs in model organisms
- Caenorhabditis elegans
- M117.3
- Caenorhabditis elegans
- ftt-2
- Caenorhabditis elegans
- par-5
- Drosophila melanogaster
- 14-3-3zeta
- Mus musculus
- Ywhaz
- Rattus norvegicus
- Ywhaz
- Saccharomyces cerevisiae
- BMH1
- Saccharomyces cerevisiae
- BMH2
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as YWHAZ
Selected references
External links
- EPD
- ORF Accession
- NM_145690
- CDS Accession
- NP_663723
- OMIM
- 601288
- HPRD
- 03183
- Ensembl
- YWHAZ
- UniProt/Swiss-Prot
- 1433Z_HUMAN
- GeneCards
- YWHAZ
- Entrez Gene
- 7534
- GenAtlas
- YWHAZ
- Internet
- Search Google