Cell Senescence Entries for YWHAZ
- Cell Types
- Glioblastoma
- Cell Lines
- A172
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lee et al. (2015) BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells. Cell Death Dis 5(2)e1537 (PubMed)
YWHAZ Gene Information
- HGNC symbol
- YWHAZ
- Aliases
- 14-3-3-zeta; KCIP-1; YWHAD
- Common name
- tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
- Entrez Id
- 7534
- Description
- This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008].
YWHAZ Ontologies
- Gene Ontology
-
Process: GO:7165; signal transduction
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:6468; protein phosphorylation
GO:34613; cellular protein localization
GO:122; negative regulation of transcription by RNA polymerase II
GO:43066; negative regulation of apoptotic process
GO:51683; establishment of Golgi localization
GO:90168; Golgi reassembly
GO:70372; regulation of ERK1 and ERK2 cascade
GO:90128; regulation of synapse maturation
GO:16310; phosphorylation
And 9 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:5615; extracellular space
GO:42470; melanosome
GO:31982; vesicle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:72562; blood microparticle
And 3 more GO terms Function: GO:3723; RNA binding
GO:4497; monooxygenase activity
GO:42802; identical protein binding
GO:5515; protein binding
GO:140297; DNA-binding transcription factor binding
GO:45296; cadherin binding
GO:19901; protein kinase binding
GO:31625; ubiquitin protein ligase binding
GO:44325; transmembrane transporter binding
GO:16301; kinase activity
GO:19904; protein domain specific binding
And 1 more GO terms
Homologs of YWHAZ in Model Organisms
- Caenorhabditis elegans
- M117.3
- Caenorhabditis elegans
- ftt-2
- Caenorhabditis elegans
- par-5
- Drosophila melanogaster
- 14-3-3zeta
- Mus musculus
- Ywhaz
- Rattus norvegicus
- Ywhaz
- Saccharomyces cerevisiae
- BMH1
- Saccharomyces cerevisiae
- BMH2
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as YWHAZ
External links
- OMIM
- 601288
- Ensembl
- ENSG00000164924
- Entrez Gene
- 7534
- UniGene
- 492407
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- YWHAZ
- GeneCards
- YWHAZ