Cell Senescence Entries for FOS

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Phillips et al. (1992) Renewed DNA synthesis in senescent WI-38 cells by expression of an inducible chimeric c-fos construct. J Cell Physiol 151(1)206-12 (PubMed)

FOS Gene Information

HGNC symbol
FOS 
Aliases
AP-1; c-fos 
Common name
Fos proto-oncogene, AP-1 transcription factor subunit 
Entrez Id
2353
Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].

FOS Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:6954; inflammatory response
GO:45893; positive regulation of transcription, DNA-templated
GO:6366; transcription by RNA polymerase II
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:34614; cellular response to reactive oxygen species
GO:71276; cellular response to cadmium ion
GO:60395; SMAD protein signal transduction
GO:1901216; positive regulation of neuron death
And 29 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:32993; protein-DNA complex
GO:35976; transcription factor AP-1 complex
GO:16020; membrane
And 2 more GO terms
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:70412; R-SMAD binding
GO:976; transcription cis-regulatory region binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
And 7 more GO terms
Show all GO terms

Homologs of FOS in Model Organisms

Danio rerio
fosaa
Danio rerio
FOS (1 of many)
Drosophila melanogaster
kay
Mus musculus
Fos
Rattus norvegicus
Fos

In other databases

GenAge human genes
  • This gene is present as FOS

External links

OMIM
164810
Ensembl
ENSG00000170345
Entrez Gene
2353
UniGene
25647
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOS
GeneCards
FOS