Cell Senescence Entries for CEBPB
- Cell Types
- Prostate cancer
- Cell Lines
- LNCaP
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Induces
- Observations
- Loss of C/EBP-beta (CEBPB) expression prevented growth arrest following androgen deprivation or anti-androgen challenge. Suppression of C/EBP-beta under low androgen conditions resulted in reduced expression of SASP genes, a decrease in SA-heterochromatin foci and increased numbers of Ki67-positive cells. Prostate cancer cells expressing C/EBP-beta exhibited morphological changes, reduced cell growth and increased senescence. It was also found that senescence contributed to cell survival under androgen deprivation, and C/EBP-beta-deficient cells were significantly more susceptible to killing by cytotoxic chemotherapy following androgen deprivation.
- Primary Reference
CEBPB Gene Information
- HGNC symbol
- CEBPB
- Aliases
- TCF5; IL6DBP; NF-IL6; C/EBP-beta
- Common name
- CCAAT/enhancer binding protein beta
- Entrez Id
- 1051
- Description
- This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
CEBPB Ontologies
- Gene Ontology
-
Process: GO:6953; acute-phase response
GO:50873; brown fat cell differentiation
GO:71230; cellular response to amino acid stimulus
GO:71347; cellular response to interleukin-1
GO:71222; cellular response to lipopolysaccharide
GO:71407; cellular response to organic cyclic compound
GO:42742; defense response to bacterium
GO:1892; embryonic placenta development
GO:72574; hepatocyte proliferation
GO:6955; immune response
GO:6954; inflammatory response
And 22 more GO terms Cellular component: GO:36488; CHOP-C/EBP complex
GO:779; condensed chromosome, centromeric region
GO:5737; cytoplasm
GO:790; nuclear chromatin
GO:16363; nuclear matrix
GO:5654; nucleoplasm
GO:5634; nucleus
Function: GO:3677; DNA binding
GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
GO:977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:35259; glucocorticoid receptor binding
GO:35035; histone acetyltransferase binding
GO:42826; histone deacetylase binding
GO:19900; kinase binding
GO:5515; protein binding
GO:46982; protein heterodimerization activity
And 7 more GO terms
Homologs of CEBPB in Model Organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Cebpb
- GenAge human genes
- This gene is present as CEBPB
External links
- OMIM
- 189965
- Ensembl
- ENSG00000172216
- Entrez Gene
- 1051
- UniGene
- 517106
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- CEBPB
- GeneCards
- CEBPB