LongevityMap Gene

Gene details

HGNC symbol
FOXO1 
Aliases
FKH1; FKHR; FOXO1A 
Common name
forkhead box O1 
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Cytogenetic Location
13q14.11
UCSC Genome Browser
View 13q14.11 on the UCSC genome browser
OMIM
136533
Ensembl
ENSG00000150907
UniProt/Swiss-Prot
FOXO1_HUMAN
Entrez Gene
2308
UniGene
370666
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
foxo1b
Mus musculus
Foxo1
Rattus norvegicus
Foxo1

In other databases

GenAge human genes
  • This gene is present as FOXO1

Studies (9)

Significant/Non-significant: 3/6

Study 1

Longevity Association
Non-significant
Population
Italian
Study Design
The (T/C, 97347 bp) polymorphism was examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females)
Conclusions
No significant differences relative to longevity were found
Indentifier
97347T/C
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Japanese
    Study Design
    3 intronic polymorphisms were examined in 122 Japanese semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33)
    Conclusions
    No significant differences relative to longevity were found
    Indentifier
    FOXO1
    Reference

      Study 3

      Longevity Association
      Significant
      Population
      Chinese (Han)
      Study Design
      Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals
      Conclusions
      Two SNPs of FOXO1A were found to be associated with longevity in women (P = 0.01-0.005)
      Indentifier
      rs2755209
      Reference

        Study 4

        Longevity Association
        Non-significant
        Population
        American of Japanese origin
        Study Design
        Nested-case control study of 5 candidate longevity genes in 8006 Japanese American men from the Honolulu Heart Program and 3741 men part of the Honolulu Asia Aging Study
        Conclusions
        Genetic variants in ADIPOQ, FOXO1A, SIRT1 and COQ7 were not associated with longevity
        Indentifier
        rs2755209
        Reference

          Study 5

          Longevity Association
          Significant
          Population
          Dutch
          Study Design
          1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls
          Conclusions
          As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing
          Indentifier
          FOXO1
          Reference

            Study 6

            Longevity Association
            Non-significant
            Population
            American (Caucasian)
            Study Design
            Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
            Conclusions
            Although no genome-wide associations were significant, several SNPs in some previously associated genes with longevity had suggestive associations with age at death or morbidity-free survival at age 65 years. Noteworthy results included two SNPs within FOXO1A (rs10507486 and rs4943794) associated with age at death.
            Indentifier
            rs4943794
            Reference

              Study 7

              Longevity Association
              Non-significant
              Population
              Germany, Italian, Chinese (Han)
              Study Design
              36 haplotype-tagging SNPs (htSNPs) in the gene regions of FOXO1, FOXO4, and FOXO6 were examined in Germany cohort which consist of 1447 centenarians/nonagenarians (95-110 y, mean age: 98.8 y, approx. 75% female) and 1029 younger controls (60-75 y, mean age: 66.8 y, approx. 75% female) for longevity association analysis. Then these htSNPs were examined in Italian women samples which consist of 166 long-lived individuals (90–109 years, mean age: 98.39 years) and 216 younger controls (18–48 years; mean age: 31.06 years).
              Conclusions
              None of the FOXO1, FOXO4, and FOXO6 genes plays a significant role in the ability to reach old age in Germany. FOXO1 was not associated with longevity in Italian either.
              Indentifier
              rs17446593
              Reference

                Study 8

                Longevity Association
                Significant
                Population
                Chinese (Han)
                Study Design
                Three SNPs in FOXO1A and three in FOXO3A were analyzed in a sample of 760 centenarians (578 female and 182 male) and 1060 middle-age controls (378 female and 682 male)
                Conclusions
                In FOXO1A, rs2755209 and rs2755213 were found to be negatively associated with longevity in women (OR = 0.70 and 0.71, p = .007 and .015; dominant model). In the dominant model for men, FOXO1A-rs2755213 was marginally and negatively associated with longevity (OR = 0.65, p = .025) and the association of FOXO1A- rs2755209 is not significant (OR = 0.73, p = .093).
                Indentifier
                rs2755209
                Reference

                  Study 9

                  Longevity Association
                  Non-significant
                  Population
                  Italian (Southern)
                  Study Design
                  A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
                  Conclusions
                  After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
                  Indentifier
                  rs2701896
                  Reference