Drosophila melanogasterGenAge entry for foxo (Drosophila melanogaster)

Gene information (ID: 286)

Symbol
foxo
Aliases
3143; Afx; anon-WO0118547.374; cg3143; CG3143; dfoxo; dF
Name
Forkhead box, sub-group O
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Transcriptional regulator

Potential relevance to longevity and/or ageing

Observations
Overexpression extends lifespan.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    dFOXO, a downstream effector of the insulin/insulin-like growth factor signaling, was overexpressed in the adult Drosophila fat body, which increased lifespan and reduced fecundity of females but had no effect on male lifespan.
    Lifespan Effect
    Increase
    Genetic Manipulation
    Overexpression
    Longevity Category
    Pro-Longevity
    Primary reference
      Observations
      Age-specific mortality analysis showed that overexpression of dFOXO in the fat-body of adult females increased median (by 21-33%) and maximum lifespan and lowered the age-specific mortality compared to control flies at all ages, in two independent experiments. Initiation of dFOXO overexpression at different ages increased subsequent lifespan compared to controls, with the magnitude of the increase decreasing as the flies were put on RU486 at older age. The effects of removal of dFOXO overexpression at different ages closely mirrored those of induction of expression , and produced shorter lifespan compared to +RU486 controls, with the shortest lifespans observed in flies taken off RU486 at the earlier ages.
      % change in avg or median lifespan
      Median lifespan is 21-33% higher.
      Lifespan Effect
      Increase
      Genetic Manipulation
      Overexpression
      Longevity Category
      Pro-Longevity
      Primary reference

        In other databases

        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as FOXO4
        GenDR gene manipulations
        • This gene is present as foxo
        • A homolog of this gene for Mus musculus is present as Foxo3
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as FOXO4

        Homologs in other organisms

        Caenorhabditis elegans
        let-381
        Danio rerio
        si:ch211-206a7.2
        Homo sapiens
        FOXO4
        Mus musculus
        Foxo3
        Rattus norvegicus
        Foxo3

        External links

        FlyBase
        Search
        Ensembl
        Search
        Entrez Gene
        View on Entrez Gene database (41709)
        Homologues
        Search HomoloGene
        UniProt
        Search
        Internet
        Search Google or Search Google Scholar