LongevityMap Gene

Gene details

HGNC symbol: IRS1
Aliases: HIRS-1
Common name: insulin receptor substrate 1
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Cytogenetic Location: 2q36.3
UCSC Genome Browser: View 2q36.3 on the UCSC genome browser
OMIM: 147545
Ensembl: ENSG00000169047
UniProt/Swiss-Prot: A0A024R499_HUMAN
Entrez Gene: 3667
UniGene: 471508
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: irs1
Drosophila melanogaster: chico
Mus musculus: Irs1
Rattus norvegicus: Irs1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as chico
A homolog of this gene for Mus musculus is present as Irs1

GenAge human genes

This gene is present as IRS1

GenDR gene manipulations

A homolog of this gene for Drosophila melanogaster is present as chico

Studies (4)

Significant/Non-significant: 0/4

Study 1

Longevity Association

Non-significant

Population

Study Design

G/A, codon 972 polymorphism was examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females)

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

2 exonic polymorphisms were examined in 122 Japanese semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33)

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

Codon 972 A/G SNP was examined in 1576 individuals aged >85

Conclusions

Arg allele seems to contribute to longevity in females, though this was not statistically significant

Indentifier

Reference

Study 4

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier