Drosophila melanogasterGenAge entry for chico (Drosophila melanogaster)

Gene information (ID: 124)

Symbol
chico
Aliases
anon-WO0078940.1; anon-WO0078940.4; BcDNA.GH11263; Bc
Name
Insulin receptor substrate-1
Organism
Drosophila melanogaster (AnAge)
Known functions and activities
Insulin receptor substrate

Potential relevance to longevity and/or ageing

Observations
Lifespan extension of 48% in homozygotes and 36% in heterozygotes.
% change in avg or median lifespan
Lifespan is up to 48% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Irs1
    • A homolog of this gene for Mus musculus is present as Irs2
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IRS1
    • A homolog of this gene for Homo sapiens is present as IRS2
    GenDR gene expression
    • A homolog of this gene for Mus musculus is present as Irs2
    GenDR gene manipulations
    • This gene is present as chico
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as IRS1
    • A homolog of this gene for Homo sapiens is present as IRS2

    Homologs in other organisms

    Danio rerio
    irs2b
    Danio rerio
    si:ch211-284e13.4
    Danio rerio
    irs2a
    Danio rerio
    irs1
    Danio rerio
    si:ch73-335l21.1
    Danio rerio
    irs4a
    Homo sapiens
    IRS4
    Homo sapiens
    IRS2
    Homo sapiens
    IRS1
    Mus musculus
    Irs2
    Mus musculus
    Irs1
    Mus musculus
    Irs3
    Mus musculus
    Irs4
    Rattus norvegicus
    Irs3
    Rattus norvegicus
    Irs2
    Rattus norvegicus
    Irs1

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (64880)
    Homologues
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    UniProt
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    Internet
    Search Google or Search Google Scholar