GenDR Dietary Restriction Gene Manipulation: chico
Gene Information (Entrez Gene ID: 64880)
- Symbol
- chico
- Aliases
- anon-WO0078940.1 anon-WO0078940.4 BcDNA.GH11263 BcDNA:GH11263 CG5686 chic Chico CHICO dIRS Dmel\CG5686 fs(2)4 fs(2)ry4 IRS IRS/chico
- Name
- Insulin receptor substrate-1
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 64880
Potential relevance to dietary restriction and ageing
- Observations
-
Mutation in chico extends mean, median, and maximum lifespan by 56%, 48%, and 42% in homozygotes and 44%, 36%, and 35% in heterozygotes. chico mutation produces dwarf, long-lived females at normal nutrition. Male heterozygous live 13% longer than wild-type, but male homozygous have a shortened lifespan [188]. Wild-type and chico mutant females have similar peak lifespan under DR, but the food concentration at which these are achieved is shifted to higher amounts. chico mutation induces a state equivalent to submaximal, DR-induced slowing of aging [2576].
- References
-
In other databases
- GenAge model organism genes
- GenAge human genes
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Irs2
- LongevityMap
Homologs
- Danio rerio
- irs2b
- Danio rerio
- si:ch211-284e13.4
- Danio rerio
- irs2a
- Danio rerio
- irs1
- Danio rerio
- si:ch73-335l21.1
- Danio rerio
- irs4a
- Homo sapiens
- IRS4
- Homo sapiens
- IRS2
- Homo sapiens
- IRS1
- Mus musculus
- Irs2
- Mus musculus
- Irs1
- Mus musculus
- Irs3
- Mus musculus
- Irs4
- Rattus norvegicus
- Irs3
- Rattus norvegicus
- Irs2
- Rattus norvegicus
- Irs1
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 64880
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar