GenAge entry for IRS2 (Homo sapiens)
Gene name (HAGRID: 34)
- HGNC symbol
- IRS2
- Aliases
- Common name
- insulin receptor substrate 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
IRS2 and IRS1 mediate many of the cellular actions of insulin (INS). Results from model organisms suggest IRS2 is involved in the IGF1/GH1 axis that appears to influence ageing in model organisms. In Drosophila, loss of chico, an insulin receptor substrate, extends lifespan [188]. IRS2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer [1919]. In another experiment, however, IRS2 knockout mice were reported to have a shorter median lifespan. Heterozygous animals had normal lifespans [1924]. IRS2 may also be involved in the extended lifespan of other mouse strains [292]. In humans, mutations in IRS2 have been associated with diabetes [1659]. IRS2 likely plays a role in some human age-related pathologies, but its exact impact on the human ageing process is unknown.
Cytogenetic information
- Cytogenetic band
- 13q34
- Location
- 109,753,837 bp to 109,786,567 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0002053; positive regulation of mesenchymal cell proliferation
GO:0002903; negative regulation of B cell apoptotic process
GO:0006006; glucose metabolic process
GO:0007165; signal transduction
GO:0007420; brain development
GO:0008283; cell proliferation
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0009749; response to glucose
GO:0010748; negative regulation of plasma membrane long-chain fatty acid transport
And 19 more GO terms Cellular component: GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0043234; protein complex
Function: GO:0004871; signal transducer activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
GO:0019904; protein domain specific binding
GO:0043548; phosphatidylinositol 3-kinase binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0071889; 14-3-3 protein binding
And 1 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- PTPN11, IRS1, MYC, EGFR, INSR, EPOR, BCL2, GRB2, SIRT1, YWHAZ, PIK3R1, ESR1, PIK3CA
- STRING interaction network
Retrieve sequences for IRS2
Homologs in model organisms
In other databases
- GenAge model organism genes
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Irs2
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as chico
- LongevityMap
- This gene is present as IRS2
Selected references
External links
- EPD
- ORF Accession
- NM_003749
- CDS Accession
- NP_003740
- OMIM
- 600797
- HPRD
- 02878
- Ensembl
- IRS2
- UniProt/Swiss-Prot
- IRS2_HUMAN
- GeneCards
- IRS2
- Entrez Gene
- 8660
- GenAtlas
- IRS2
- Internet
- Search Google