Mus musculusGenAge entry for Irs2 (Mus musculus)

Gene information (ID: 378)

Symbol
Irs2
Aliases
Irs-2
Name
insulin receptor substrate 2
Organism
Mus musculus (AnAge)
Known functions and activities
Cytoplasmic signalling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines

Potential relevance to longevity and/or ageing

Observations
Irs2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer.
% change in avg or median lifespan
Lifespan is 18% higher.
Lifespan Effect
Increase
Genetic Manipulation
Knockout
Longevity Category
Anti-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Drosophila melanogaster is present as chico
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as IRS2
    GenDR gene expression
    • This gene is present as Irs2
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as chico
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as IRS2

    Homologs in other organisms

    Danio rerio
    irs2b
    Danio rerio
    irs2a
    Drosophila melanogaster
    chico
    Homo sapiens
    IRS2
    Rattus norvegicus
    Irs2

    External links

    Mouse Genome Informatics
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    Ensembl
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    Entrez Gene
    View on Entrez Gene database (384783)
    Homologues
    Search HomoloGene
    UniProt
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    Internet
    Search Google or Search Google Scholar