GenAge entry for Irs2 (Mus musculus)
Gene information (ID: 378)
- Symbol
- Irs2
- Aliases
- Irs-2
- Name
- insulin receptor substrate 2
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Cytoplasmic signalling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines
Potential relevance to longevity and/or ageing
- Observations
- Irs2 brain-specific knockout mice were overweight, hyperinsulinemic, glucose intolerant, yet more active and lived up to 18% longer.
- % change in avg or median lifespan
- Lifespan is 18% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Knockout
- Longevity Category
- Anti-Longevity
- Primary reference
-
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as chico
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as IRS2
- GenDR gene expression
- This gene is present as Irs2
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as chico
- LongevityMap
- A homolog of this gene for Homo sapiens is present as IRS2
Homologs in other organisms
External links
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (384783)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar