- Symbol
- Ncor2
- Aliases
- SMRT; N-CoR; SMRTe
- Name
- nuclear receptor co-repressor 2
- Organism
- Mus musculus (AnAge)
- Observations
- In older animals, SMRTmRID1 mice developed cataracts, alopecia and gray hair sooner than wt controls. In addition, the rotarod test demonstrated that SMRTmRID1 mice had diminished sensorimotor coordination, implicating a premature aging phenotype. SMRTmRID1 mice had elevated levels of fasting serum triglycerides, cholesterol, glucose, insulin and leptin as well as reduced adiponectin concentrations, compared to control animals. Kaplan-Meier survival curves showed that both female (p=0.028) and male (p=0.012) SMRTmRID1 mice had shortened lifespan.
- % change in avg or median lifespan
- Average lifespan is 30-50% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Mutation
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as NCOR2
- Caenorhabditis elegans
- gei-8
- Danio rerio
- ncor2
- Drosophila melanogaster
- Smr
- Homo sapiens
- NCOR2
- Rattus norvegicus
- Ncor2
- Saccharomyces cerevisiae
- SNT1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (20602)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar