Saccharomyces cerevisiaeGenAge entry for SOD2 (Saccharomyces cerevisiae)

Gene information (ID: 623)

Symbol
SOD2
Name
Manganese-containing superoxide dismutase
Organism
Saccharomyces cerevisiae (AnAge)
Known functions and activities
Protects cells against oxygen toxicity

Potential relevance to longevity and/or ageing

Observations
Overexpression of Sod1 and Sod2 extends survival by 30%.
% change in avg or median lifespan
Lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference
    Observations
    72% replicative lifespan decrease
    % change in avg or median lifespan
    Replicative lifespan is 72% lower.
    Lifespan Effect
    Decrease
    Genetic Manipulation
    Deletion
    Longevity Category
    Necessary for fitness
    Primary reference
      Observations
      Mean chronological lifespan decreased in the a strain by more than 50%
      % change in avg or median lifespan
      Mean chronological lifespan is more than 50% lower.
      Lifespan Effect
      Decrease
      Genetic Manipulation
      Deletion
      Longevity Category
      Necessary for fitness
      Primary reference

        In other databases

        GenAge model organism genes
        • A homolog of this gene for Drosophila melanogaster is present as Sod2
        • A homolog of this gene for Mus musculus is present as Sod2
        GenAge human genes
        • A homolog of this gene for Homo sapiens is present as SOD2
        GenDR gene manipulations
        • This gene is present as SOD2
        LongevityMap
        • A homolog of this gene for Homo sapiens is present as SOD2

        Homologs in other organisms

        Caenorhabditis elegans
        sod-3
        Danio rerio
        sod2
        Drosophila melanogaster
        Sod2
        Homo sapiens
        SOD2
        Mus musculus
        Sod2
        Rattus norvegicus
        Sod2

        External links

        Saccharomyces Genome Database
        Search
        Ensembl
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        Entrez Gene
        View on Entrez Gene database (856399)
        Homologues
        Search HomoloGene
        UniProt
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        Internet
        Search Google or Search Google Scholar