LongevityMap Gene

Gene details

HGNC symbol
SOD2 
Aliases
IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD 
Common name
superoxide dismutase 2 
Description
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Cytogenetic Location
6q25.3
UCSC Genome Browser
View 6q25.3 on the UCSC genome browser
OMIM
147460
Ensembl
ENSG00000112096
UniProt/Swiss-Prot
A0A0C4DFU1_HUMAN
Entrez Gene
6648
UniGene
487046
1000 Genomes
1000 Genomes

Homologs in model organisms

Caenorhabditis elegans
sod-3
Danio rerio
sod2
Drosophila melanogaster
Sod2
Mus musculus
Sod2
Rattus norvegicus
Sod2
Saccharomyces cerevisiae
SOD2
Schizosaccharomyces pombe
SPBC16A3.14

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2
  • A homolog of this gene for Drosophila melanogaster is present as Sod2
  • A homolog of this gene for Mus musculus is present as Sod2
GenAge human genes
  • This gene is present as SOD2
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as SOD2

Studies (9)

Significant/Non-significant: 3/6

Study 1

Longevity Association
Non-significant
Population
Ashkenazi Jewish (Jerusalem)
Study Design
C9T, Ala (GCT) to Val (GTT), SNP was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years)
Conclusions
There was an increase in the percentage of T allele (51% versus 33.3%) in older Ashkenazi male subjects and a corresponding increase in the percentage (45.5% versus 25%) of TT homozygotes, though this was not significant after correcting for multiple testing
Indentifier
C9T
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Dutch
    Study Design
    Exon 16 C/T SNP was examined in 1576 individuals aged >85
    Conclusions
    No association with reduced mortality risk was found
    Indentifier
    16C/T
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Italian
      Study Design
      401C/T SNP was examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old)
      Conclusions
      No significant difference in genotypic frequencies was found between centenarians and controls
      Indentifier
      401C/T
      Reference

        Study 4

        Longevity Association
        Non-significant
        Population
        Jordanian
        Study Design
        Polymorphisms were genotyped in 130 elderly subjects (57 females, mean age: 90.01 years) and 135 young control subjects (67 females, mean age: 33.43 years) for longevity association
        Conclusions
        No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05). SOD2 -9T/C and MTHFR 677C/T were not associated with longevity in the Jordanian population.
        Indentifier
        -9T/C
        Reference

          Study 5

          Longevity Association
          Significant
          Population
          Danish
          Study Design
          SNPs rs4880 in MnSOD and rs1050450 in GPX1 were genotyped in 1650 individuals from the Danish 1905 cohort (follow-up time: 1998–2008, age at intake: 92–93 years, number of deaths: 1589 (96.3%)) and investigated for the association with aging and longevity
          Conclusions
          Decreased mortality of individuals holding either the MnSOD rs4880 C or the GPX1 rs1050450 T alleles (HR (MnSOD(CC/CT)) = 0.91, p = 0.002), HR (GPX1(TT/TC)) = 0.93, p = 0.008)) was observed, as well as a synergetic effect (HR = 0.76, p = 0.001). Genetic variation in MnSOD and GPX1 may be associated with aging and longevity.
          Indentifier
          rs4880
          Reference

            Study 6

            Longevity Association
            Significant
            Population
            American (Caucasian)
            Study Design
            Genome-wide association study in 801 centenarians and 914 healthy controls
            Conclusions
            281 SNPs were found to discriminate between cases and controls
            Indentifier
            rs2758331
            Reference

              Study 7

              Longevity Association
              Non-significant
              Population
              Italian (Southern)
              Study Design
              A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
              Conclusions
              After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
              Indentifier
              rs2758331
              Reference

                Study 8

                Longevity Association
                Significant
                Population
                Danish
                Study Design
                38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
                Conclusions
                NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. This result is consistent with their associations with physical functioning and suggests that the variability of genes in the pro-antioxidant pathway can influence survival through an effect on physical performances, at least in the analyzed cohort.
                Indentifier
                rs2758331
                Reference

                  Study 9

                  Longevity Association
                  Non-significant
                  Population
                  German
                  Study Design
                  19 SNPs were examined in 1612 long-lived individuals (centenarians and nonagenarians) and 1104 younger controls as well as a subgroup of 748 centenarians from 1612 LLIs and 1104 younger controls.
                  Conclusions
                  No association was detected between the tested SNPs and the longevity phenotype, in the entire long-lived sample set nor in the centenarian subgroup analysis. There was no considerable influence of sequence variation in the SOD genes on human longevity in Germans.
                  Indentifier
                  rs5746141
                  Reference