Ageing-Associated Genes in Model Organisms

Found 2152 results. Showing results 1 to 2152.

Entrez ID Symbol Name Organism Longevity influence Max average lifespan change More details
42186 14-3-3epsilon CG31196 gene product from transcript CG31196-RA Drosophila melanogaster Anti-Longevity 49% Increase 14-3-3epsilon
40575 5-HT2A 5-hydroxytryptamine (serotonin) receptor 2A Drosophila melanogaster Anti-Longevity 90% Increase 5-HT2A
852380 AAC3 ADP/ATP Carrier Saccharomyces cerevisiae Anti-Longevity 15% Increase AAC3
855581 AAH1 Adenine AminoHydrolase Saccharomyces cerevisiae Anti-Longevity Increase AAH1
181727 aak-2 AMP-Activated Kinase Caenorhabditis elegans Pro-Longevity Increase and Decrease aak-2
181492 aakb-1 AMP-Activated Kinase Beta subunit Caenorhabditis elegans Pro-Longevity Decrease aakb-1
176552 aakb-2 AMP-Activated Kinase Beta subunit Caenorhabditis elegans Pro-Longevity Decrease aakb-2
181736 aakg-2 Protein AAKG-2 Caenorhabditis elegans Pro-Longevity 47% Increase aakg-2
185079 aat-8 Amino Acid Transporter Caenorhabditis elegans Anti-Longevity 30% Increase aat-8
853755 AAT1 Aspartate AminoTransferase Saccharomyces cerevisiae Pro-Longevity 25% Increase AAT1
850714 AAT2 Aspartate AminoTransferase Saccharomyces cerevisiae Pro-Longevity 15% Increase AAT2
183860 abcx-1 ABC transporter, eXtended Caenorhabditis elegans Anti-Longevity 16% Increase abcx-1
850450 ABP1 Actin Binding Protein Saccharomyces cerevisiae Unclear Increase and Decrease ABP1
173404 abu-11 Activated in Blocked Unfolded protein response Caenorhabditis elegans Pro-Longevity 28% Increase abu-11
852925 ACB1 Acyl-CoA-Binding Saccharomyces cerevisiae Anti-Longevity Increase ACB1
177654 acdh-13 Acyl CoA DeHydrogenase Caenorhabditis elegans Anti-Longevity 57% Increase acdh-13
181706 ace-1 abnormal ACEtylcholinesterase Caenorhabditis elegans Anti-Longevity 8% Increase ace-1
852266 ACH1 Ach1p Saccharomyces cerevisiae Necessary For Fitness Decrease ACH1
185044 acl-11 ACyLtransferase-like Caenorhabditis elegans Anti-Longevity Increase acl-11
180780 acn-1 Inactive angiotensin-converting enzyme-related protein Caenorhabditis elegans Anti-Longevity 21% Increase acn-1
176121 aco-2 ACOnitase Caenorhabditis elegans Anti-Longevity 20% Increase aco-2
853230 ACO2 ACOnitase Saccharomyces cerevisiae Unclear Increase and Decrease ACO2
178190 acs-20 Protein ACS-20 Caenorhabditis elegans Pro-Longevity 50% Decrease acs-20
176005 acs-4 fatty Acid CoA Synthetase family Caenorhabditis elegans Anti-Longevity 6% Increase acs-4
176785 acs-5 fatty Acid CoA Synthetase family Caenorhabditis elegans Anti-Longevity 52% Increase acs-5
174472 acs-7 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase acs-7
850846 ACS2 Acetyl CoA Synthetase Saccharomyces cerevisiae Pro-Longevity 70% Decrease ACS2
852059 ADA2 transcriptional ADAptor Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ADA2
224129 Adcy5 adenylate cyclase 5 Mus musculus Anti-Longevity 30% Increase Adcy5
855222 ADD37 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae Necessary For Fitness Decrease ADD37
853629 ADD66 Alpha1-proteinase inhibitor-Degradation Deficient Saccharomyces cerevisiae Necessary For Fitness Decrease ADD66
851272 ADE1 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE1
855501 ADE12 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE12
855149 ADE17 ADEnine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease ADE17
854295 ADE2 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE2
853118 ADE3 ADEnine requiring Saccharomyces cerevisiae Unclear Increase and Decrease ADE3
855346 ADE4 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE4
852617 ADE5,7 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE5,7
852952 ADE6 ADEnine requiring Saccharomyces cerevisiae Anti-Longevity Increase ADE6
854068 ADH1 Alcohol DeHydrogenase Saccharomyces cerevisiae Anti-Longevity 20% Increase ADH1
855349 ADH2 Alcohol DeHydrogenase Saccharomyces cerevisiae Unclear Increase and Decrease ADH2
851812 ADK1 ADenylate Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease ADK1
172542 adr-1 Adenosine Deaminase that acts on RNA Caenorhabditis elegans Pro-Longevity 50% Decrease adr-1
176022 adr-2 Adenosine Deaminase that acts on RNA Caenorhabditis elegans Pro-Longevity 50% Decrease adr-2
851802 ADR1 Alcohol Dehydrogenase Regulator Saccharomyces cerevisiae Necessary For Fitness 35% Decrease ADR1
11549 Adra1a adrenergic receptor, alpha 1a Mus musculus Pro-Longevity 10% Increase Adra1a
11548 Adra1b adrenergic receptor, alpha 1b Mus musculus Anti-Longevity 11% Decrease Adra1b
855086 AEP1 ATPase ExPression Saccharomyces cerevisiae Unclear Increase and Decrease AEP1
856737 AFG3 ATPase Family Gene Saccharomyces cerevisiae Anti-Longevity 20% Increase AFG3
856132 AGC1 Aspartate-Glutamate Carrier Saccharomyces cerevisiae Anti-Longevity 30% Increase AGC1
174762 age-1 AGEing alteration AGE-1, abnormal DAuer Formation DAF-23 Caenorhabditis elegans Anti-Longevity 1000% Increase age-1
176695 agmo-1 Protein AGMO-1 Caenorhabditis elegans Pro-Longevity 30% Decrease agmo-1
850333 AGP1 high-Affinity Glutamine Permease Saccharomyces cerevisiae Anti-Longevity Increase AGP1
11607 Agtr1a Angiotensin II receptor, type 1a Mus musculus Anti-Longevity 26% Increase Agtr1a
172889 aha-1 Protein AHA-1 Caenorhabditis elegans Pro-Longevity 10% Decrease aha-1
38342 AhcyL1 Adenosylhomocysteinase like 1 Drosophila melanogaster Anti-Longevity 13% Increase AhcyL1
42043 AhcyL2 Adenosylhomocysteinase like 2 Drosophila melanogaster Anti-Longevity 21% Increase AhcyL2
853543 AIM24 Altered Inheritance rate of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease AIM24
855189 AIM36 Altered Inheritance rate of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease AIM36
181719 ain-1 ALG-1 INteracting protein Caenorhabditis elegans Pro-Longevity 10% Decrease ain-1
179898 aip-1 Arsenite Inducible Protein Caenorhabditis elegans Pro-Longevity 50% Decrease aip-1
852351 AKL1 Ark family Kinase-Like protein Saccharomyces cerevisiae Anti-Longevity 20% Increase AKL1
851857 AKR1 AnKyrin Repeat-containing protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease AKR1
179424 akt-1 AKT kinase family Caenorhabditis elegans Anti-Longevity Increase akt-1
41957 Akt1 CG4006 gene product from transcript CG4006-RA Drosophila melanogaster Pro-Longevity 11% Decrease Akt1
11651 Akt1 thymoma viral proto-oncogene 1 Mus musculus Anti-Longevity 12% Increase Akt1
855205 ALD3 ALdehyde Dehydrogenase Saccharomyces cerevisiae Necessary For Fitness Decrease ALD3
854556 ALD4 ALdehyde Dehydrogenase Saccharomyces cerevisiae Anti-Longevity 50% Increase ALD4
856044 ALD6 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae Anti-Longevity Increase ALD6
173468 alg-2 Argonaute (plant)-Like Gene Caenorhabditis elegans Pro-Longevity 24% Decrease alg-2
855764 ALG12 Asparagine-Linked Glycosylation Saccharomyces cerevisiae Anti-Longevity 25% Increase ALG12
852196 ALG3 dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase Saccharomyces cerevisiae Anti-Longevity 10% Increase ALG3
855874 ALG5 Asparagine-Linked Glycosylation Saccharomyces cerevisiae Anti-Longevity 50% Increase ALG5
854163 ALG6 dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Saccharomyces cerevisiae Anti-Longevity 15% Increase ALG6
173510 alh-6 ALdehyde deHydrogenase Caenorhabditis elegans Pro-Longevity Increase and Decrease alh-6
31957 alpha-Man-I Alpha Mannosidase I Drosophila melanogaster Anti-Longevity 39% Increase alpha-Man-I
851690 ALT2 ALanine Transaminase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ALT2
854973 AMD1 AMP Deaminase Saccharomyces cerevisiae Anti-Longevity Increase AMD1
852455 AMN1 Antagonist of Mitotic exit Network Saccharomyces cerevisiae Necessary For Fitness Decrease AMN1
186047 amt-2 AMmonium Transporter homolog Caenorhabditis elegans Anti-Longevity 20% Increase amt-2
856527 ANS1 Ans1p Saccharomyces cerevisiae Necessary For Fitness 25% Decrease ANS1
176773 ant-1.1 Adenine Nucleotide Translocator Caenorhabditis elegans Anti-Longevity 40% Increase ant-1.1
3640787 APC10 potential anaphase-promoting complex processivity factor Apc10 Saccharomyces cerevisiae Pro-Longevity Increase and Decrease APC10
854423 APC5 anaphase promoting complex subunit 5 Saccharomyces cerevisiae Unclear Decrease APC5
850792 APC9 anaphase promoting complex subunit 9 Saccharomyces cerevisiae Pro-Longevity Decrease APC9
852589 APE3 AminoPEptidase Saccharomyces cerevisiae Necessary For Fitness Decrease APE3
180783 apl-1 Beta-amyloid-like protein Caenorhabditis elegans Pro-Longevity 30% Increase apl-1
853723 APL2 clathrin Adaptor Protein complex Large chain Saccharomyces cerevisiae Necessary For Fitness 25% Decrease APL2
855869 APM1 clathrin Adaptor Protein complex Medium chain Saccharomyces cerevisiae Necessary For Fitness 50% Decrease APM1
11816 Apoe Apolipoprotein E Mus musculus Pro-Longevity Decrease Apoe
178989 aps-1 Protein APS-1 Caenorhabditis elegans Anti-Longevity 8% Increase aps-1
171691 aps-3 daPtin, Small chain (clathrin associated complex) Caenorhabditis elegans Anti-Longevity 40% Increase aps-3
854986 APT1 Adenine PhosphoribosylTransferase Saccharomyces cerevisiae Anti-Longevity Increase APT1
181019 apy-1 APYrase Caenorhabditis elegans Pro-Longevity Decrease apy-1
855660 AQR1 Aqr1p Saccharomyces cerevisiae Unannotated AQR1
856404 ARD1 ARrest Defective Saccharomyces cerevisiae Necessary For Fitness Decrease ARD1
191609 arf-1.1 ADP-Ribosylation Factor related Caenorhabditis elegans Anti-Longevity 10% Increase arf-1.1
851335 ARF1 ADP-Ribosylation Factor Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ARF1
853374 ARG2 ARGinine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease ARG2
180080 argk-1 ARGinine Kinase Caenorhabditis elegans Pro-Longevity 25% Increase argk-1
228359 Arhgap1 Rho GTPase activating protein 1 Mus musculus Pro-Longevity Decrease Arhgap1
855711 ARK1 Actin Regulating Kinase Saccharomyces cerevisiae Unclear Increase and Decrease ARK1
178405 arl-8 ARF-Like Caenorhabditis elegans Pro-Longevity Decrease arl-8
11865 Arntl aryl hydrocarbon receptor nuclear translocator-like Mus musculus Pro-Longevity Decrease Arntl
856173 ARO7 AROmatic amino acid requiring Saccharomyces cerevisiae Necessary For Fitness Decrease ARO7
856530 ARP1 Actin-Related Protein Saccharomyces cerevisiae Necessary For Fitness 40% Decrease ARP1
180446 arr-1 ARRestin family Caenorhabditis elegans Anti-Longevity 35% Increase arr-1
175247 arx-4 ARp2/3 compleX component Caenorhabditis elegans Pro-Longevity Decrease arx-4
175605 asb-1 Protein ASB-1 Caenorhabditis elegans Anti-Longevity 6% Increase asb-1
180718 asb-2 ATP Synthase B homolog Caenorhabditis elegans Anti-Longevity Increase asb-2
853327 ASF1 Anti-Silencing Function Saccharomyces cerevisiae Necessary For Fitness 74% Decrease ASF1
172673 asg-1 ATP Synthase G homolog Caenorhabditis elegans Anti-Longevity Increase asg-1
180956 asg-2 ATP synthase subunit Caenorhabditis elegans Anti-Longevity Increase asg-2
854676 ASG1 Activator of Stress Genes Saccharomyces cerevisiae Necessary For Fitness Decrease ASG1
174838 ash-2 ASH histone methyltransferase complex subunit (Drosophila absent, small or homeotic discs) Caenorhabditis elegans Anti-Longevity 30% Increase ash-2
176879 asm-3 Acid SphingoMyelinase Caenorhabditis elegans Anti-Longevity 50% Increase asm-3
174590 atad-3 ATPase family AAA domain-containing protein 3 Caenorhabditis elegans Anti-Longevity 29% Increase atad-3
181405 atf-6 ATF (cAMP-dependent transcription factor) family Caenorhabditis elegans Anti-Longevity 18% Increase atf-6
179922 atfs-1 Activating Transcription Factor associated with Stress Caenorhabditis elegans Anti-Longevity 26% Decrease atfs-1
179246 atg-18 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Unclear 20% Decrease atg-18
176921 atg-3 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-3
190777 atg-4.1 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-4.1
3565022 atg-4.2 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-4.2
171735 atg-5 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Decrease atg-5
178005 atg-7 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Unclear Increase atg-7
178561 atg-9 AuTophaGy (yeast Atg homolog) Caenorhabditis elegans Pro-Longevity Increase and Decrease atg-9
852695 ATG1 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 70% Decrease ATG1
39454 Atg1 Autophagy-specific gene 1 Drosophila melanogaster Pro-Longevity 25% Increase Atg1
850684 ATG10 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG10
852518 ATG12 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG12
856315 ATG13 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG13
852425 ATG14 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG14
850432 ATG15 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 40% Decrease ATG15
855194 ATG16 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG16
851142 ATG17 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 70% Decrease ATG17
850577 ATG18 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ATG18
38344 Atg2 Autophagy-specific gene 2 Drosophila melanogaster Pro-Longevity 28% Increase Atg2
855479 ATG2 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG2
2539317 atg20 sorting nexin Atg20 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase atg20
856004 ATG21 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG21
855937 ATG29 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG29
855954 ATG5 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG5
11793 Atg5 autophagy related 5 Mus musculus Pro-Longevity 17% Increase Atg5
37141 Atg7 Autophagy-specific gene 7 Drosophila melanogaster Pro-Longevity Decrease Atg7
856576 ATG7 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness 70% Decrease ATG7
852200 ATG8 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG8
32001 Atg8a Autophagy-related 8a Drosophila melanogaster Pro-Longevity Increase and Decrease Atg8a
851406 ATG9 AuTophaGy related Saccharomyces cerevisiae Necessary For Fitness Decrease ATG9
856137 ATH1 Acid TreHalase Saccharomyces cerevisiae Necessary For Fitness Decrease ATH1
11920 Atm Ataxia telangiectasia mutated homolog (human) Mus musculus Pro-Longevity Decrease Atm
175716 atp-2 ATP synthase F1 subunit gamma Caenorhabditis elegans Anti-Longevity 43% Increase atp-2
172195 atp-3 ATP synthase subunit Caenorhabditis elegans Anti-Longevity 21% Increase atp-3
179025 atp-4 ATP synthase subunit Caenorhabditis elegans Anti-Longevity Increase atp-4
179541 atp-5 ATP synthase subunit Caenorhabditis elegans Anti-Longevity Increase atp-5
852177 ATP1 ATP synthase Saccharomyces cerevisiae Unclear Increase and Decrease ATP1
854893 ATP18 ATP synthase Saccharomyces cerevisiae Necessary For Fitness 40% Decrease ATP18
853585 ATP2 ATP synthase F1 subunit gamma Saccharomyces cerevisiae Pro-Longevity 50% Decrease ATP2
852327 ATP3 ATP synthase Saccharomyces cerevisiae Anti-Longevity 50% Increase ATP3
856027 ATP4 ATP synthase Saccharomyces cerevisiae Necessary For Fitness 10% Decrease ATP4
36760 ATPCL ATP citrate lyase Drosophila melanogaster Anti-Longevity 32% Increase ATPCL
245000 Atr Ataxia telangiectasia and Rad3 related Mus musculus Pro-Longevity Decrease Atr
180049 atx-3 Protein ATX-3 Caenorhabditis elegans Anti-Longevity 50% Increase atx-3
40044 Aut1 Aut1 -CG6877 gene product from transcript CG6877-RA Drosophila melanogaster Pro-Longevity 28% Decrease Aut1
853457 AVT1 Amino acid Vacuolar Transport Saccharomyces cerevisiae Necessary For Fitness Decrease AVT1
179432 B0024.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase B0024.4
180344 B0250.5 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial Caenorhabditis elegans Anti-Longevity 10% Increase B0250.5
176217 B0303.2 Protein B0303.2 Caenorhabditis elegans Anti-Longevity 5% Increase B0303.2
174734 B0491.5 Protein B0491.5 Caenorhabditis elegans Anti-Longevity 60% Increase B0491.5
172954 B0511.6 Protein B0511.6 Caenorhabditis elegans Anti-Longevity 50% Increase B0511.6
182030 B0546.3 Protein B0546.3 Caenorhabditis elegans Anti-Longevity 27% Increase B0546.3
35900 babo baboon Drosophila melanogaster Anti-Longevity 16% Increase babo
176330 baf-1 Barrier to Autointegration Factor Caenorhabditis elegans Pro-Longevity 28% Decrease baf-1
43038 bam bag of marbles Drosophila melanogaster Pro-Longevity 50% Increase bam
852360 BAP2 Branched-chain Amino acid Permease Saccharomyces cerevisiae Necessary For Fitness Decrease BAP2
180982 bar-1 beta-catenin Caenorhabditis elegans Pro-Longevity 45% Decrease bar-1
853974 BAS1 BASal Saccharomyces cerevisiae Anti-Longevity 30% Increase BAS1
12028 Bax Bcl2-associated X protein Mus musculus Unannotated Increase Bax
181423 bcat-1 Branched-chain-amino-acid aminotransferase, cytosolic Caenorhabditis elegans Anti-Longevity 25% Increase bcat-1
33819 bchs blue cheese Drosophila melanogaster Pro-Longevity 45% Decrease bchs
853350 BCK1 Bypass of C Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease BCK1
851981 BCS1 ubiquinol-cytochrome c reductase (bc1) Synthesis Saccharomyces cerevisiae Necessary For Fitness Decrease BCS1
854778 BCY1 Bypass of CYclase mutations Saccharomyces cerevisiae Necessary For Fitness Decrease BCY1
177345 bec-1 BEClin (human autophagy) homolog Caenorhabditis elegans Pro-Longevity 40% Decrease bec-1
852499 BEM1 Bud EMergence Saccharomyces cerevisiae Necessary For Fitness 75% Decrease BEM1
172054 bet-1 BET-1 Caenorhabditis elegans Pro-Longevity Decrease bet-1
853551 BIR1 Baculoviral IAP Repeat-containing protein Saccharomyces cerevisiae Pro-Longevity Increase BIR1
172917 blmp-1 Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog Caenorhabditis elegans Pro-Longevity 20% Decrease blmp-1
39322 Bmcp Bmcp Drosophila melanogaster Anti-Longevity Increase Bmcp
856924 BMH1 Brain Modulosignalin Homologue Saccharomyces cerevisiae Unclear Increase and Decrease BMH1
851676 BMH2 Brain Modulosignalin Homologue Saccharomyces cerevisiae Pro-Longevity Increase BMH2
179948 bmk-1 Kinesin-like protein Caenorhabditis elegans Pro-Longevity 25% Increase bmk-1
853541 BNA2 Biosynthesis of Nicotinic Acid Saccharomyces cerevisiae Anti-Longevity Increase BNA2
850608 BNA6 Biosynthesis of Nicotinic Acid Saccharomyces cerevisiae Pro-Longevity Decrease BNA6
855450 BNI1 Bud Neck Involved Saccharomyces cerevisiae Necessary For Fitness 65% Decrease BNI1
856850 BOI2 Bem1 (One) Interacting protein Saccharomyces cerevisiae Anti-Longevity 25% Increase BOI2
850398 BPH1 Beige Protein Homolog Saccharomyces cerevisiae Necessary For Fitness Decrease BPH1
850645 BPT1 Bile Pigment Transporter Saccharomyces cerevisiae Anti-Longevity 20% Increase BPT1
181481 bra-1 BMP receptor Associated protein family Caenorhabditis elegans Pro-Longevity 25% Decrease bra-1
12189 Brca1 Breast cancer 1 Mus musculus Pro-Longevity Decrease Brca1
855787 BRE5 Bre5p Saccharomyces cerevisiae Unclear Increase and Decrease BRE5
851524 BSC1 Bypass of Stop Codon Saccharomyces cerevisiae Anti-Longevity 20% Increase BSC1
851868 BSC2 Bypass of Stop Codon Saccharomyces cerevisiae Anti-Longevity 20% Increase BSC2
44801 bsk basket Drosophila melanogaster Pro-Longevity 16% Decrease bsk
850519 BST1 Bst1p Saccharomyces cerevisiae Anti-Longevity 25% Increase BST1
175018 bub-3 yeast BUB homolog Caenorhabditis elegans Anti-Longevity 6% Increase bub-3
12236 Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) Mus musculus Pro-Longevity Increase and Decrease Bub1b
12237 Bub3 budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae) Mus musculus Pro-Longevity 12% Decrease Bub3
851029 BUD6 BUD site selection Saccharomyces cerevisiae Unannotated BUD6
851459 BUG1 Binder of USO1 and GRH1 Saccharomyces cerevisiae Unclear Increase and Decrease BUG1
854929 BUL2 ubiquitin-ubiquitin ligase BUL2 Saccharomyces cerevisiae Unannotated 16% Increase BUL2
188726 bus-4 Protein BUS-4 Caenorhabditis elegans Pro-Longevity 10% Decrease bus-4
180821 bus-8 Bacterially Un-Swollen (M. nematophilum resistant) Caenorhabditis elegans Pro-Longevity 58% Decrease bus-8
173764 C01F1.1 Protein C01F1.1 Caenorhabditis elegans Pro-Longevity 28% Decrease C01F1.1
173427 C03H5.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase C03H5.3
182280 C06A5.1 Protein C06A5.1 Caenorhabditis elegans Pro-Longevity 39% Decrease C06A5.1
176368 C07A9.2 Protein C07A9.2 Caenorhabditis elegans Pro-Longevity 26% Decrease C07A9.2
182438 C09B7.2 transposase Caenorhabditis elegans Anti-Longevity Increase C09B7.2
181537 C11H1.3 Protein C11H1.3 Caenorhabditis elegans Pro-Longevity 10% Decrease C11H1.3
174637 C14A4.9 Protein C14A4.9 Caenorhabditis elegans Pro-Longevity 14% Decrease C14A4.9
174427 C18E9.10 Protein C18E9.10 Caenorhabditis elegans Anti-Longevity Increase C18E9.10
174428 C18E9.4 Protein C18E9.4 Caenorhabditis elegans Anti-Longevity 60% Increase C18E9.4
182926 C26B2.2 Protein C26B2.2 Caenorhabditis elegans Anti-Longevity Increase C26B2.2
180804 C26B9.3 Protein C26B9.3 Caenorhabditis elegans Pro-Longevity 12% Decrease C26B9.3
177708 C27B7.7 Protein C27B7.7 Caenorhabditis elegans Anti-Longevity Increase C27B7.7
175836 C28H8.11 Protein C28H8.11 Caenorhabditis elegans Anti-Longevity 15% Increase C28H8.11
175180 C29F9.1 Protein C29F9.1 Caenorhabditis elegans Pro-Longevity Decrease C29F9.1
175179 C29F9.2 Protein C29F9.2 Caenorhabditis elegans Pro-Longevity 12% Decrease C29F9.2
183168 C33F10.12 Protein C33F10.12 Caenorhabditis elegans Anti-Longevity Increase C33F10.12
3565046 C33H5.18 Protein C33H5.18 Caenorhabditis elegans Pro-Longevity 44% Decrease C33H5.18
172966 C34B2.6 Lon protease homolog, mitochondrial Caenorhabditis elegans Anti-Longevity 11% Increase C34B2.6
183228 C35A11.3 Protein C35A11.3 Caenorhabditis elegans Anti-Longevity Increase C35A11.3
178230 C36H8.1 Protein C36H8.1 Caenorhabditis elegans Anti-Longevity Increase C36H8.1
183399 C42C1.3 Protein C42C1.3 Caenorhabditis elegans Anti-Longevity 60% Increase C42C1.3
177367 C46G7.2 Protein C46G7.2 Caenorhabditis elegans Anti-Longevity 44% Increase C46G7.2
174789 C47D12.2 Protein C47D12.2 Caenorhabditis elegans Anti-Longevity 6% Increase C47D12.2
177858 C47E12.2 Protein C47E12.2 Caenorhabditis elegans Anti-Longevity 36% Increase C47E12.2
172321 C48E7.2 Protein C48E7.2 Caenorhabditis elegans Anti-Longevity 26% Increase C48E7.2
175898 C56G2.1 Protein C56G2.1 Caenorhabditis elegans Anti-Longevity 20% Increase C56G2.1
856772 CAJ1 Caj1p Saccharomyces cerevisiae Necessary For Fitness Decrease CAJ1
180769 calu-1 CALUmenin (calcium-binding protein) homolog Caenorhabditis elegans Pro-Longevity Decrease calu-1
32947 car carnation Drosophila melanogaster Pro-Longevity Increase car
2540626 car2 ornithine transaminase Car2 Schizosaccharomyces pombe Anti-Longevity Increase car2
12366 Casp2 caspase 2 Mus musculus Pro-Longevity Decrease Casp2
40048 Cat Catalase Drosophila melanogaster Pro-Longevity 33% Increase Cat
12359 Cat Catalase Mus musculus Pro-Longevity 21% Increase Cat
854292 CAT5 CATabolite repression Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CAT5
12389 Cav1 caveolin, caveolae protein 1 Mus musculus Pro-Longevity 50% Decrease Cav1
856347 CBP2 Cytochrome B mRNA Processing Saccharomyces cerevisiae Necessary For Fitness Decrease CBP2
853085 CBP4 Cytochrome B mRNA Processing Saccharomyces cerevisiae Necessary For Fitness Decrease CBP4
852417 CBP6 Cbp6p Saccharomyces cerevisiae Anti-Longevity 25% Increase CBP6
8582838 Cbr-daf-2 C. briggsae CBR-DAF-2 protein Caenorhabditis briggsae Anti-Longevity 40% Increase Cbr-daf-2
33081 Cbs Cystathionine beta-synthase Drosophila melanogaster Pro-Longevity 43% Increase Cbs
181215 cbs-1 Cystathionine Beta-Synthase Caenorhabditis elegans Pro-Longevity 50% Increase cbs-1
851491 CBS1 Cbs1p Saccharomyces cerevisiae Anti-Longevity 37% Increase CBS1
174713 cchl-1 Cytochrome C Heme-Lyase Caenorhabditis elegans Anti-Longevity 50% Increase cchl-1
172832 cco-1 Cytochrome C Oxidase Caenorhabditis elegans Anti-Longevity 80% Increase cco-1
176707 cco-2 Cytochrome C Oxidase Caenorhabditis elegans Anti-Longevity 60% Increase cco-2
178184 ccr-4 CCR (yeast CCR4/NOT complex component) homolog Caenorhabditis elegans Pro-Longevity 33% Decrease ccr-4
855054 CCS1 Ccs1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CCS1
174318 cct-1 T-complex protein 1 subunit alpha Caenorhabditis elegans Anti-Longevity 10% Increase cct-1
174330 cct-4 Chaperonin Containing TCP-1 Caenorhabditis elegans Anti-Longevity 28% Increase cct-4
175819 cct-6 Chaperonin Containing TCP-1 Caenorhabditis elegans Anti-Longevity 20% Increase cct-6
176928 cct-8 Chaperonin Containing TCP-1 Caenorhabditis elegans Anti-Longevity 16% Increase cct-8
117353 Cct1 CTP:phosphocholine cytidylyltransferase 1 Drosophila melanogaster Pro-Longevity 8% Increase Cct1
172353 cdc-25.1 Cell Division Cycle related Caenorhabditis elegans Anti-Longevity Increase cdc-25.1
176260 cdc-25.3 Cell Division Cycle related Caenorhabditis elegans Anti-Longevity 40% Increase cdc-25.3
174624 cdc-48.1 Protein CDC-48.1 Caenorhabditis elegans Anti-Longevity 50% Increase cdc-48.1
851306 CDC13 Cell Division Cycle Saccharomyces cerevisiae Pro-Longevity Decrease CDC13
218294 Cdc14b CDC14 cell division cycle 14B Mus musculus Pro-Longevity Cdc14b
851019 CDC25 Cdc25p Saccharomyces cerevisiae Anti-Longevity 50% Increase CDC25
850597 CDC26 anaphase promoting complex subunit CDC26 Saccharomyces cerevisiae Pro-Longevity Decrease CDC26
853244 CDC6 Cell Division Cycle Saccharomyces cerevisiae Anti-Longevity 20% Increase CDC6
852881 CDH1 CDC20 Homolog Saccharomyces cerevisiae Necessary For Fitness 45% Decrease CDH1
171784 cdk-7 Cyclin-Dependent Kinase family Caenorhabditis elegans Pro-Longevity Decrease cdk-7
36727 Cdk5 Cyclin-dependent kinase 5 Drosophila melanogaster Pro-Longevity 33% Decrease Cdk5
12572 Cdk7 cyclin-dependent kinase 7 Mus musculus Pro-Longevity Decrease Cdk7
12575 Cdkn1a Cyclin-dependent kinase inhibitor 1A Mus musculus Anti-Longevity Increase Cdkn1a
175559 cdtl-7 Protein CDTL-7 Caenorhabditis elegans Pro-Longevity 22% Decrease cdtl-7
12606 Cebpa CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus Unannotated Increase Cebpa
12608 Cebpb CCAAT/enhancer binding protein (C/EBP), beta Mus musculus Unannotated Increase Cebpb
174265 cec-3 Protein CEC-3 Caenorhabditis elegans Anti-Longevity Increase cec-3
178272 ced-3 CEll Death abnormality Caenorhabditis elegans Anti-Longevity 19% Increase ced-3
175811 ceh-10 ceh-10 Homeobox Caenorhabditis elegans Pro-Longevity 40% Decrease ceh-10
180671 ceh-18 Protein CEH-18 Caenorhabditis elegans Anti-Longevity Increase ceh-18
3565545 ceh-20 Protein CEH-20 Caenorhabditis elegans Pro-Longevity 12% Decrease ceh-20
176096 ceh-23 Protein CEH-23 Caenorhabditis elegans Pro-Longevity 25% Increase ceh-23
181530 ceh-37 Protein CEH-37 Caenorhabditis elegans Pro-Longevity 8% Decrease ceh-37
172814 cel-1 mRNA Capping Enzyme Like Caenorhabditis elegans Pro-Longevity 59% Decrease cel-1
182749 CELE_C17H1.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase CELE_C17H1.7
173963 CELE_C25H3.9 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase CELE_C25H3.9
183078 CELE_C31B8.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 13% Increase CELE_C31B8.4
183126 CELE_C32H11.1 Protein C32H11.1 Caenorhabditis elegans Anti-Longevity Increase CELE_C32H11.1
183129 CELE_C32H11.5 Protein C32H11.5 Caenorhabditis elegans Anti-Longevity Increase CELE_C32H11.5
177786 CELE_C33A12.1 Protein C33A12.1 Caenorhabditis elegans Anti-Longevity 50% Increase CELE_C33A12.1
179499 CELE_D1054.14 Protein D1054.14 Caenorhabditis elegans Anti-Longevity 36% Increase CELE_D1054.14
183917 CELE_D1054.8 Dehydrogenase Caenorhabditis elegans Anti-Longevity Increase CELE_D1054.8
177262 CELE_E03H12.5 Protein E03H12.5 Caenorhabditis elegans Anti-Longevity Increase CELE_E03H12.5
179331 CELE_F11A3.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 14% Increase CELE_F11A3.2
175926 CELE_F23F12.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase CELE_F23F12.3
176828 CELE_F29C4.2 Protein F29C4.2 Caenorhabditis elegans Anti-Longevity 100% Increase CELE_F29C4.2
176402 CELE_F40F12.7 Protein F40F12.7 Caenorhabditis elegans Pro-Longevity Decrease CELE_F40F12.7
185704 CELE_F43D2.1 Protein F43D2.1 Caenorhabditis elegans Pro-Longevity 20% Decrease CELE_F43D2.1
186068 CELE_F49F1.12 Protein F49F1.12 Caenorhabditis elegans Anti-Longevity Increase CELE_F49F1.12
173558 CELE_F52C6.2 Protein F52C6.2 Caenorhabditis elegans Pro-Longevity 19% Decrease CELE_F52C6.2
179849 CELE_F53F4.11 Protein F53F4.11 Caenorhabditis elegans Anti-Longevity 27% Increase CELE_F53F4.11
176945 CELE_F53H1.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase CELE_F53H1.3
177772 CELE_F56D5.5 Protein F56D5.5 Caenorhabditis elegans Anti-Longevity 20% Increase CELE_F56D5.5
186593 CELE_F59B2.8 Protein F59B2.8 Caenorhabditis elegans Pro-Longevity Decrease CELE_F59B2.8
172933 CELE_F59C6.5 Protein F59C6.5 Caenorhabditis elegans Anti-Longevity 70% Increase CELE_F59C6.5
176838 CELE_R02D3.3 Protein R02D3.3 Caenorhabditis elegans Anti-Longevity 13% Increase CELE_R02D3.3
174683 CELE_R03D7.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 13% Increase CELE_R03D7.4
187596 CELE_R05A10.5 Protein R05A10.5 Caenorhabditis elegans Anti-Longevity Increase CELE_R05A10.5
173140 CELE_T06G6.4 Protein T06G6.4 Caenorhabditis elegans Anti-Longevity Increase CELE_T06G6.4
173237 CELE_W09C5.8 Protein W09C5.8 Caenorhabditis elegans Anti-Longevity 100% Increase CELE_W09C5.8
180262 CELE_Y39B6A.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 50% Increase CELE_Y39B6A.3
189761 CELE_Y39F10C.1 Protein Y39F10C.1 Caenorhabditis elegans Anti-Longevity Increase CELE_Y39F10C.1
171792 CELE_Y39G10AR.8 Protein Y39G10AR.8 Caenorhabditis elegans Anti-Longevity 24% Increase CELE_Y39G10AR.8
189814 CELE_Y41C4A.11 hypothetical protein Caenorhabditis elegans Anti-Longevity 13% Increase CELE_Y41C4A.11
189875 CELE_Y43F8B.12 Protein Y43F8B.12 Caenorhabditis elegans Anti-Longevity Increase CELE_Y43F8B.12
174915 CELE_Y46G5A.20 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase CELE_Y46G5A.20
171919 CELE_Y47G6A.18 Protein Y47G6A.18 Caenorhabditis elegans Pro-Longevity Decrease CELE_Y47G6A.18
173061 CELE_Y47H9C.1 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase CELE_Y47H9C.1
173005 CELE_Y52B11A.9 hypothetical protein Caenorhabditis elegans Pro-Longevity 20% Decrease CELE_Y52B11A.9
190220 CELE_Y53F4B.23 Protein Y53F4B.23 Caenorhabditis elegans Anti-Longevity Increase CELE_Y53F4B.23
171874 CELE_Y54E10BR.4 Protein Y54E10BR.4 Caenorhabditis elegans Anti-Longevity 15% Increase CELE_Y54E10BR.4
177036 CELE_Y69A2AR.19 Protein Y69A2AR.19 Caenorhabditis elegans Anti-Longevity 19% Increase CELE_Y69A2AR.19
176648 CELE_Y75B8A.13 Protein Y75B8A.13 Caenorhabditis elegans Anti-Longevity Increase CELE_Y75B8A.13
190713 CELE_Y75B8A.33 Protein Y75B8A.33 Caenorhabditis elegans Anti-Longevity Increase CELE_Y75B8A.33
172616 cep-1 C. Elegans P-53-like protein Caenorhabditis elegans Anti-Longevity 33% Increase cep-1
38928 cert ceramide transfer protein Drosophila melanogaster Pro-Longevity Decrease cert
35751 CG11165 CG11165 Drosophila melanogaster Pro-Longevity 54% Increase CG11165
38100 CG13890 CG13890 Drosophila melanogaster Pro-Longevity 31% Increase CG13890
32955 CG14207 CG14207-PA Drosophila melanogaster Pro-Longevity 5% Increase CG14207
43369 CG17856 CG17856 gene product from transcript CG17856-RA Drosophila melanogaster Anti-Longevity 18% Increase CG17856
59170 CG18809 CG18809 gene product from transcript CG18809-RA Drosophila melanogaster Anti-Longevity 19% Increase CG18809
33231 CG2789 CG2789 Drosophila melanogaster Anti-Longevity 27% Increase CG2789
37996 CG3776 Juvenile hormone esterase binding protein 29 (DmP29) Drosophila melanogaster Anti-Longevity 43% Decrease CG3776
37996 CG3776 Juvenile hormone esterase binding protein 29 (DmP29) Drosophila melanogaster Pro-Longevity 39% Decrease CG3776
7354421 CG42358 CG42358 Drosophila melanogaster Anti-Longevity Increase and Decrease CG42358
39761 CG5389 CG5389 gene product from transcript CG5389-RA Drosophila melanogaster Anti-Longevity 11% Increase CG5389
32565 CG9172 CG9172 gene product from transcript CG9172-RA Drosophila melanogaster Anti-Longevity 46% Increase CG9172
32328 CG9940 CG9940 Drosophila melanogaster Pro-Longevity Increase CG9940
181790 cgt-2 Ceramide glucosyltransferase 2 Caenorhabditis elegans Anti-Longevity 40% Increase cgt-2
176434 chc-1 Clathrin Heavy Chain Caenorhabditis elegans Pro-Longevity 40% Decrease chc-1
856911 CHD1 Chromatin organization modifier, Helicase, and DNA-binding domains Saccharomyces cerevisiae Unclear Increase and Decrease CHD1
179666 che-11 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 40% Increase che-11
186607 che-13 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 40% Increase che-13
180401 che-2 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 50% Increase che-2
172593 che-3 abnormal CHEmotaxis Caenorhabditis elegans Anti-Longevity 100% Increase che-3
50883 Chek2 CHK2 checkpoint homolog (S. pombe) Mus musculus Pro-Longevity Decrease Chek2
42066 cher cheerio Drosophila melanogaster Pro-Longevity 9% Increase cher
64880 chico Insulin receptor substrate-1 Drosophila melanogaster Anti-Longevity 48% Increase chico
3565921 chk-1 CHeckpoint Kinase Caenorhabditis elegans Anti-Longevity 25% Increase chk-1
856099 CHL1 Chl1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CHL1
43928 chm chameau Drosophila melanogaster Anti-Longevity 24% Increase chm
172303 chn-1 Protein CHN-1 Caenorhabditis elegans Anti-Longevity 7% Increase chn-1
175707 cid-1 Caffeine Induced Death (S. pombe Cid) homolog Caenorhabditis elegans Anti-Longevity Increase cid-1
67006 Cisd2 CDGSH iron sulfur domain 2 Mus musculus Pro-Longevity Increase and Decrease Cisd2
176126 cit-1.2 CyclIn T Caenorhabditis elegans Pro-Longevity Decrease cit-1.2
855732 CIT1 CITrate synthase Saccharomyces cerevisiae Necessary For Fitness Decrease CIT1
850361 CIT2 CITrate synthase Saccharomyces cerevisiae Necessary For Fitness Decrease CIT2
854227 CKA2 Casein Kinase Alpha' subunit Saccharomyces cerevisiae Anti-Longevity Increase CKA2
176546 cku-70 Caenorhabditis KU Caenorhabditis elegans Anti-Longevity Increase cku-70
855418 CLA4 CLn Activity dependant Saccharomyces cerevisiae Necessary For Fitness 60% Decrease CLA4
853002 CLB1 CycLin B Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CLB1
856236 CLB2 CycLin B Saccharomyces cerevisiae Necessary For Fitness 50% Decrease CLB2
178238 clec-186 C-type LECtin Caenorhabditis elegans Anti-Longevity Increase clec-186
184216 clec-227 C-type LECtin Caenorhabditis elegans Anti-Longevity Increase clec-227
852657 CLG1 Cyclin-Like Gene Saccharomyces cerevisiae Necessary For Fitness Decrease CLG1
175729 clk-1 Coenzyme Q7 homolog Caenorhabditis elegans Anti-Longevity Increase and Decrease clk-1
176065 clk-2 CLocK (biological timing) abnormality Caenorhabditis elegans Unannotated 25% Increase clk-2
851191 CLN3 Cln3p Saccharomyces cerevisiae Anti-Longevity Decrease CLN3
12753 Clock Circadian locomotor output cycles kaput Mus musculus Pro-Longevity 15% Decrease Clock
31647 cm carmine Drosophila melanogaster Pro-Longevity Decrease cm
179572 cnb-1 CalciNeurin B Caenorhabditis elegans Anti-Longevity 30% Increase cnb-1
855287 COA6 Cytochrome Oxidase Assembly Saccharomyces cerevisiae Necessary For Fitness Decrease COA6
259335 col-93 COLlagen Caenorhabditis elegans Anti-Longevity Increase col-93
12842 Col1a1 collagen, type I, alpha 1 Mus musculus Pro-Longevity Decrease Col1a1
852288 COQ1 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ1
854154 COQ10 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ10
40988 Coq2 Coenzyme Q biosynthesis protein 2 Drosophila melanogaster Anti-Longevity 31% Increase Coq2
854057 COQ3 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ3
854930 COQ5 COenzyme Q Saccharomyces cerevisiae Necessary For Fitness Decrease COQ5
12850 Coq7 demethyl-Q 7 Mus musculus Anti-Longevity 30% Increase Coq7
852235 COR1 CORe protein of QH2 cytochrome c reductase Saccharomyces cerevisiae Necessary For Fitness Decrease COR1
802462 cox1 Cytochrome c oxidase I Podospora anserina Unannotated Increase cox1
802462 cox1 cytochrome c oxidase subunit 1 Podospora anserina Unannotated Increase cox1
855971 COX11 Cytochrome c OXidase Saccharomyces cerevisiae Necessary For Fitness Decrease COX11
856516 COX23 Cytochrome OXidase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease COX23
171986 cpn-3 CalPoNin Caenorhabditis elegans Anti-Longevity 10% Increase cpn-3
3565393 cpna-3 Protein CPNA-3 Caenorhabditis elegans Anti-Longevity Increase cpna-3
853267 CPS1 CarboxyPeptidase yscS Saccharomyces cerevisiae Necessary For Fitness Decrease CPS1
854267 CRC1 CaRnitine Carrier Saccharomyces cerevisiae Anti-Longevity 25% Increase CRC1
174634 crn-5 Cell-death-Related Nuclease Caenorhabditis elegans Anti-Longevity 41% Increase crn-5
34592 crol crooked legs Drosophila melanogaster Anti-Longevity 27% Increase crol
259368 crtc-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 53% Increase crtc-1
852324 CSG2 Calcium Sensitive Growth Saccharomyces cerevisiae Necessary For Fitness 40% Decrease CSG2
101830758 Csnk1e casein kinase 1, epsilon Mesocricetus auratus Unannotated Increase Csnk1e
177391 csp-2 CaSPase Caenorhabditis elegans Anti-Longevity Increase csp-2
856142 CSR2 Csr2p Saccharomyces cerevisiae Anti-Longevity Increase CSR2
180708 cst-1 Caenorhabditis STE20-like kinase Caenorhabditis elegans Pro-Longevity Increase and Decrease cst-1
852330 CST26 Chromosome STability Saccharomyces cerevisiae Anti-Longevity 40% Increase CST26
851843 CTA1 CaTalase A Saccharomyces cerevisiae Anti-Longevity Increase and Decrease CTA1
180853 ctbp-1 C-terminal-binding protein 1 Caenorhabditis elegans Anti-Longevity 20% Increase ctbp-1
13019 Ctf1 cardiotrophin 1 Mus musculus Anti-Longevity 18% Increase Ctf1
856254 CTF4 Chromosome Transmission Fidelity Saccharomyces cerevisiae Pro-Longevity Decrease CTF4
180079 cth-1 CystaTHionine gamma lyase Caenorhabditis elegans Pro-Longevity 15% Decrease cth-1
174155 cth-2 Putative cystathionine gamma-lyase 2 Caenorhabditis elegans Pro-Longevity 25% Decrease cth-2
851729 CTH1 Cysteine-Three-Histidine Saccharomyces cerevisiae Anti-Longevity 20% Increase CTH1
853718 CTK1 Carboxy-Terminal domain Kinase Saccharomyces cerevisiae Necessary For Fitness 80% Decrease CTK1
856241 CTR1 Copper TRansport Saccharomyces cerevisiae Pro-Longevity Increase and Decrease CTR1
852979 CTT1 Cytosolic catalase T Saccharomyces cerevisiae Unannotated Increase CTT1
176770 cua-1 CU (copper) ATPase Caenorhabditis elegans Pro-Longevity 12% Decrease cua-1
176466 cul-1 CULlin Caenorhabditis elegans Pro-Longevity Decrease cul-1
176104 cup-4 Coelomocyte UPtake defective Caenorhabditis elegans Pro-Longevity 10% Decrease cup-4
855926 CUP9 Cup9p Saccharomyces cerevisiae Necessary For Fitness 30% Decrease CUP9
176895 cutl-28 CUTiclin-Like Caenorhabditis elegans Anti-Longevity 28% Increase cutl-28
850376 CWH43 Calcofluor White Hypersensitive Saccharomyces cerevisiae Necessary For Fitness Decrease CWH43
178894 cwp-4 Coexpressed With Polycystins Caenorhabditis elegans Anti-Longevity Increase cwp-4
855612 CYB5 Cyb5p Saccharomyces cerevisiae Unannotated CYB5
172582 cyc-1 Cytochrome c1 Caenorhabditis elegans Anti-Longevity 87% Increase cyc-1
177243 cyc-2.1 CYtochrome C Caenorhabditis elegans Anti-Longevity 80% Increase cyc-2.1
853507 CYC1 CYtochrome C Saccharomyces cerevisiae Necessary For Fitness 60% Decrease CYC1
854202 CYC2 CYtochrome C Saccharomyces cerevisiae Necessary For Fitness Decrease CYC2
851192 CYC3 CYtochrome C Saccharomyces cerevisiae Necessary For Fitness 20% Decrease CYC3
181462 cyp-13B1 CYtochrome P450 family Caenorhabditis elegans Anti-Longevity 20% Increase cyp-13B1
185653 cyp-33E2 CYtochrome P450 family Caenorhabditis elegans Anti-Longevity 18% Increase cyp-33E2
180236 cyp-42A1 CYtochrome P450 family Caenorhabditis elegans Pro-Longevity 39% Decrease cyp-42A1
853452 CYR1 Adenylate cyclase Saccharomyces cerevisiae Anti-Longevity 90% Increase CYR1
853059 CYS4 CYStathionine beta-synthase Saccharomyces cerevisiae Anti-Longevity 50% Increase CYS4
854231 CYT1 ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Saccharomyces cerevisiae Unclear Increase and Decrease CYT1
853775 CYT2 cytochrome c1 heme lyase CYT2 Saccharomyces cerevisiae Necessary For Fitness 25% Decrease CYT2
173425 D1069.3 D1069.3b Caenorhabditis elegans Pro-Longevity Decrease D1069.3
172510 D2030.1 Alpha-1,2-mannosidase I Caenorhabditis elegans Anti-Longevity 9% Increase D2030.1
172513 D2030.4 Protein D2030.4 Caenorhabditis elegans Anti-Longevity 40% Increase D2030.4
174387 D2085.3 Protein D2085.3 Caenorhabditis elegans Anti-Longevity Increase D2085.3
176829 daf-1 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 46% Increase daf-1
184883 daf-10 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 60% Increase daf-10
181263 daf-12 Abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity Increase daf-12
177908 daf-14 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 44% Increase daf-14
177770 daf-15 Abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity Increase daf-15
172981 daf-16 Abnormal DAuer Formation DAF-16, fork head-related transcription factor (daf-16) Caenorhabditis elegans Pro-Longevity 45% Decrease daf-16
176869 daf-18 Abnormal DAuer Formation Caenorhabditis elegans Pro-Longevity Increase and Decrease daf-18
174577 daf-19 Abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 50% Increase daf-19
175410 daf-2 abnormal DAuer Formation DAF-2, fork head-related transcription factor (daf-2) Caenorhabditis elegans Anti-Longevity 200% Increase daf-2
191014 daf-28 Abnormal DAuer Formation Caenorhabditis elegans Pro-Longevity 15% Increase daf-28
180431 daf-3 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 16% Decrease daf-3
175781 daf-4 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 120% Increase daf-4
175054 daf-5 abnormal DAuer Formation Caenorhabditis elegans Pro-Longevity 20% Decrease daf-5
181584 daf-6 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 50% Increase daf-6
175237 daf-7 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 50% Increase daf-7
187612 daf-8 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 31% Increase daf-8
180889 daf-9 abnormal DAuer Formation Caenorhabditis elegans Anti-Longevity 74% Increase daf-9
3565075 dagl-2 DiAcylGlycerol Lipase homolog Caenorhabditis elegans Pro-Longevity 13% Increase dagl-2
856423 DAP2 YHR028C Saccharomyces cerevisiae Necessary For Fitness 19% Decrease DAP2
851583 DAS2 Dst1-delta 6-Azauracil Sensitivity Saccharomyces cerevisiae Anti-Longevity 25% Increase DAS2
33474 daw dawdle Drosophila melanogaster Anti-Longevity 35% Increase daw
852984 DBF2 DumbBell Forming Saccharomyces cerevisiae Necessary For Fitness 60% Decrease DBF2
855984 DBP1 Dead Box Protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease DBP1
852802 DBP3 Dead Box Protein Saccharomyces cerevisiae Anti-Longevity 35% Increase DBP3
850819 DCN1 Defective in Cullin Neddylation Saccharomyces cerevisiae Necessary For Fitness Decrease DCN1
176138 dcr-1 Endoribonuclease dcr-1 Caenorhabditis elegans Pro-Longevity Decrease dcr-1
189237 dct-11 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Pro-Longevity 10% Decrease dct-11
190351 dct-12 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 14% Increase dct-12
178476 dct-13 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 23% Increase dct-13
189684 dct-14 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 19% Increase dct-14
189289 dct-15 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Anti-Longevity 10% Increase dct-15
174934 dct-18 DAF-16/FOXO Controlled, germline Tumor affecting Caenorhabditis elegans Pro-Longevity 8% Decrease dct-18
853820 DCW1 Defective Cell Wall Saccharomyces cerevisiae Anti-Longevity Increase DCW1
173954 ddl-1 Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) Caenorhabditis elegans Anti-Longevity 24% Increase ddl-1
190025 ddl-2 Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) Caenorhabditis elegans Anti-Longevity 24% Increase ddl-2
175087 ddl-3 Daf-16-Dependent Longevity (WT but not daf-16 lifespan increased) Caenorhabditis elegans Anti-Longevity Increase ddl-3
852500 DER1 Der1p Saccharomyces cerevisiae Anti-Longevity 16% Increase DER1
179574 des-2 DEgeneration Suppressor Caenorhabditis elegans Anti-Longevity 60% Increase des-2
13350 Dgat1 diacylglycerol O-acyltransferase 1 Mus musculus Anti-Longevity 23% Increase Dgat1
174068 dgk-5 Putative diacylglycerol kinase K06A1.6 Caenorhabditis elegans Anti-Longevity 11% Increase dgk-5
853738 DGR2 2-Deoxy-Glucose Resistant 2 Saccharomyces cerevisiae Necessary For Fitness Decrease DGR2
179741 dhs-21 DeHydrogenases, Short chain Caenorhabditis elegans Pro-Longevity Decrease dhs-21
177676 dic-1 human DICE1 (Deleted In Cancer) homolog Caenorhabditis elegans Anti-Longevity 22% Increase dic-1
853906 DID2 Doa4-Independent Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease DID2
853142 DIE2 Derepression of ITR1 Expression Saccharomyces cerevisiae Anti-Longevity 50% Increase DIE2
851157 DIF1 Damage-regulated Import Facilitator Saccharomyces cerevisiae Necessary For Fitness 20% Decrease DIF1
174782 din-1 DAF-12 Interacting Protein Caenorhabditis elegans Pro-Longevity Decrease din-1
177875 dis-3 DIS3 (yeast disjunction abnormal) exonuclease homolog Caenorhabditis elegans Pro-Longevity 11% Decrease dis-3
36543 DJ-1alpha DJ-1alpha Drosophila melanogaster Pro-Longevity Decrease DJ-1alpha
43652 dj-1beta dj-1beta Drosophila melanogaster Pro-Longevity Decrease dj-1beta
180121 dkf-2 D Kinase Family Caenorhabditis elegans Anti-Longevity 40% Increase dkf-2
179945 dlat-1 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Caenorhabditis elegans Anti-Longevity 10% Increase dlat-1
178387 dld-1 Protein DLD-1 Caenorhabditis elegans Anti-Longevity 61% Increase dld-1
173128 dlk-1 DAP (Death Associated Protein kinase) Like Kinase Caenorhabditis elegans Pro-Longevity Decrease dlk-1
33906 DLP Daxx-like protein Drosophila melanogaster Pro-Longevity 20% Decrease DLP
853381 DLS1 Dls1p Saccharomyces cerevisiae Anti-Longevity 20% Increase DLS1
31310 dm diminutive Drosophila melanogaster Anti-Longevity 47% Decrease dm
13405 Dmd Dystrophin, muscular dystrophy Mus musculus Pro-Longevity 18% Decrease Dmd
856569 DNA2 Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent Saccharomyces cerevisiae Pro-Longevity Decrease DNA2
3772064 DNApol-gamma35 DNA polymerase Gamma Drosophila melanogaster Anti-Longevity 52% Decrease DNApol-gamma35
31309 dnc dunce Drosophila melanogaster Anti-Longevity Increase dnc
856913 DNF1 Drs2 Neo1 Family Saccharomyces cerevisiae Anti-Longevity 50% Increase DNF1
172231 dnj-21 Mitochondrial import inner membrane translocase subunit TIM14 Caenorhabditis elegans Pro-Longevity 10% Decrease dnj-21
850686 DNM1 Dnm1p Saccharomyces cerevisiae Anti-Longevity Increase DNM1
851641 DOA4 Degradation Of Alpha Saccharomyces cerevisiae Necessary For Fitness 50% Decrease DOA4
187266 dod-17 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-17
183813 dod-18 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-18
178564 dod-19 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-19
182037 dod-20 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-20
183134 dod-21 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-21
178247 dod-22 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-22
186056 dod-23 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-23
178245 dod-24 Downstream Of DAF-16 (regulated by DAF-16) Caenorhabditis elegans Anti-Longevity Increase dod-24
31118 dor deep orange Drosophila melanogaster Pro-Longevity Decrease dor
852050 DOT1 histone methyltransferase DOT1 Saccharomyces cerevisiae Necessary For Fitness 24% Decrease DOT1
851699 DPB4 Dpb4p Saccharomyces cerevisiae Necessary For Fitness 15% Decrease DPB4
854703 DPH1 DiPHthamide biosynthesis Saccharomyces cerevisiae Necessary For Fitness Decrease DPH1
33432 dpp decapentaplegic Drosophila melanogaster Pro-Longevity 29% Decrease dpp
175492 dpy-27 Protein DPY-27 Caenorhabditis elegans Pro-Longevity 24% Decrease dpy-27
3565236 drl-1 Dietary Restriction Like Caenorhabditis elegans Anti-Longevity 60% Increase drl-1
174994 drr-1 Protein DRR-1 Caenorhabditis elegans Anti-Longevity Increase drr-1
259546 drr-2 Protein DRR-2 Caenorhabditis elegans Anti-Longevity Increase drr-2
855331 DSS1 Deletion of SUV3 Supressor Saccharomyces cerevisiae Unclear Increase and Decrease DSS1
850605 DUG1 Deficient in Utilization of Glutathione Saccharomyces cerevisiae Anti-Longevity Increase DUG1
852584 DUG2 Deficient in Utilization of Glutathione Saccharomyces cerevisiae Necessary For Fitness Decrease DUG2
851457 DUN1 DNA-damage UNinducible Saccharomyces cerevisiae Necessary For Fitness 25% Decrease DUN1
180398 dve-1 DVE (Defective proVEntriculus in Drosophila) homolog Caenorhabditis elegans Pro-Longevity 53% Decrease dve-1
852034 DYN2 DYNein Saccharomyces cerevisiae Necessary For Fitness Decrease DYN2
42327 Dys Dystrophin Drosophila melanogaster Pro-Longevity Decrease Dys
39203 E(z) Enhancer of zeste Drosophila melanogaster Anti-Longevity 76% Increase E(z)
180175 E01B7.1 Protein E01B7.1 Caenorhabditis elegans Pro-Longevity Decrease E01B7.1
177242 E04A4.5 Probable mitochondrial import inner membrane translocase subunit Tim17 Caenorhabditis elegans Pro-Longevity 8% Decrease E04A4.5
3564920 eak-7 hypothetical protein Caenorhabditis elegans Unclear 30% Increase eak-7
eat-1 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 30% Increase eat-1
13183021 eat-18 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 60% Increase eat-18
24105308 eat-18 hypothetical protein Caenorhabditis elegans Anti-Longevity 14% Increase eat-18
175072 eat-2 EATing: abnormal pharyngeal pumping EAT-2 Caenorhabditis elegans Anti-Longevity Increase eat-2
174476 eat-3 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 10% Increase eat-3
179796 eat-6 EATing: abnormal pharyngeal pumping Caenorhabditis elegans Anti-Longevity 40% Increase eat-6
852370 ECM33 ExtraCellular Mutant Saccharomyces cerevisiae Necessary For Fitness Decrease ECM33
856342 ECM34 ExtraCellular Mutant Saccharomyces cerevisiae Necessary For Fitness Decrease ECM34
35540 EcR Ecdysone receptor Drosophila melanogaster Anti-Longevity 50% Increase EcR
31154 Edem1 CG3810 gene product from transcript CG3810-RC Drosophila melanogaster Anti-Longevity 30% Increase Edem1
175975 eef-1A.1 Elongation factor 1-alpha Caenorhabditis elegans Anti-Longevity 18% Increase eef-1A.1
172743 eef-2 Elongation Factor Caenorhabditis elegans Unclear Increase and Decrease eef-2
66143 Eef1e1 Eukaryotic translation elongation factor 1 epsilon 1 Mus musculus Anti-Longevity 50% Decrease Eef1e1
36271 Ef1alpha48D Elongation factor 148D Drosophila melanogaster Pro-Longevity 41% Increase Ef1alpha48D
216616 Efemp1 Epidermal growth factor-containing fibulin-like extracellular matrix protein 1 Mus musculus Pro-Longevity 20% Decrease Efemp1
854301 EFT1 Elongation Factor Two Saccharomyces cerevisiae Necessary For Fitness 30% Decrease EFT1
851993 EFT2 Elongation Factor Two Saccharomyces cerevisiae Necessary For Fitness Decrease EFT2
856070 EGD1 Enhancer of Gal4 DNA binding Saccharomyces cerevisiae Necessary For Fitness Decrease EGD1
856600 EGD2 Enhancer of Gal4 DNA binding Saccharomyces cerevisiae Necessary For Fitness 20% Decrease EGD2
179707 egl-10 EGg Laying defective Caenorhabditis elegans Anti-Longevity Increase egl-10
176992 egl-18 Erythroid-Like Transcription factor family Caenorhabditis elegans Anti-Longevity Increase egl-18
174121 egl-27 Protein EGL-27 Caenorhabditis elegans Pro-Longevity 18% Increase egl-27
179412 egl-3 EGg Laying defective Caenorhabditis elegans Anti-Longevity 65% Increase egl-3
171751 egl-30 EGg Laying defective Caenorhabditis elegans Anti-Longevity 38% Increase egl-30
176094 egl-45 EGg Laying defective Caenorhabditis elegans Anti-Longevity 52% Increase egl-45
178537 egl-8 EGg Laying defective Caenorhabditis elegans Anti-Longevity 83% Increase egl-8
179461 egl-9 EGg Laying defective Caenorhabditis elegans Anti-Longevity 20% Increase egl-9
36242 Egm enigma Drosophila melanogaster Anti-Longevity Increase Egm
266853 eif-1 Protein EIF-1 Caenorhabditis elegans Anti-Longevity 25% Increase eif-1
175138 eif-3.B Eukaryotic Initiation Factor Caenorhabditis elegans Anti-Longevity 51% Increase eif-3.B
174478 eif-3.F Eukaryotic Initiation Factor Caenorhabditis elegans Anti-Longevity 32% Increase eif-3.F
179779 eif-3.K Eukaryotic translation initiation factor 3 subunit K Caenorhabditis elegans Anti-Longevity 40% Increase eif-3.K
208691 Eif5a2 eukaryotic translation initiation factor 5A2 Mus musculus Anti-Longevity Decrease Eif5a2
39675 Eip71CD Ecdysone-induced protein 28/29kD Drosophila melanogaster Pro-Longevity 70% Increase Eip71CD
31000 elav embryonic lethal abnormal vision Drosophila melanogaster Pro-Longevity 66% Decrease elav
190775 elc-1 ELongin C Caenorhabditis elegans Anti-Longevity 12% Increase elc-1
177787 elo-1 fatty acid ELOngation Caenorhabditis elegans Anti-Longevity 11% Increase elo-1
178532 elo-2 fatty acid ELOngation Caenorhabditis elegans Anti-Longevity 9% Increase elo-2
177320 elo-5 fatty acid ELOngation Caenorhabditis elegans Pro-Longevity 45% Decrease elo-5
856019 ELP3 ELongator Protein Saccharomyces cerevisiae Anti-Longevity Increase ELP3
856002 ELP4 ELongator Protein Saccharomyces cerevisiae Anti-Longevity 30% Increase ELP4
176993 elt-6 Erythroid-Like Transcription factor family Caenorhabditis elegans Anti-Longevity 34% Increase elt-6
174314 emb-27 Protein EMB-27 Caenorhabditis elegans Anti-Longevity 10% Increase emb-27
852125 EMI1 Early Meiotic Induction Saccharomyces cerevisiae Unclear Increase and Decrease EMI1
184599 ent-5 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase ent-5
852962 ENV11 late ENdosome and Vacuole interface function Saccharomyces cerevisiae Necessary For Fitness 60% Decrease ENV11
855644 EOS1 Eos1p Saccharomyces cerevisiae Anti-Longevity 24% Increase EOS1
176679 epc-1 Enhancer of PolyComb-like Caenorhabditis elegans Anti-Longevity 20% Increase epc-1
13860 Eps8 Epidermal growth factor receptor pathway substrate 8 Mus musculus Anti-Longevity 37% Increase Eps8
13870 Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 Mus musculus Pro-Longevity 83% Decrease Ercc1
13871 Ercc2 Excision repair cross-complementing rodent repair deficiency, complementation group 2 Mus musculus Pro-Longevity Decrease Ercc2
50505 Ercc4 Excision repair cross-complementing rodent repair deficiency, complementation group 4 Mus musculus Pro-Longevity Decrease Ercc4
855441 ERG24 ERGosterol biosynthesis Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ERG24
855029 ERG5 ERGosterol biosynthesis Saccharomyces cerevisiae Necessary For Fitness 35% Decrease ERG5
855003 ERG6 ERGosterol biosynthesis Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ERG6
176868 eri-1 Enhanced RNAI (RNA interference) Caenorhabditis elegans Pro-Longevity 43% Decrease eri-1
172174 erm-1 Ezrin/Radixin/Moesin Caenorhabditis elegans Anti-Longevity 15% Increase erm-1
173325 ero-1 Endoplasmic Reticulum Oxidase Caenorhabditis elegans Anti-Longevity 32% Increase ero-1
854909 ERO1 ER oxidoreductin Saccharomyces cerevisiae Anti-Longevity 28% Increase ERO1
856152 ERV2 Essential for Respiration and Viability Saccharomyces cerevisiae Anti-Longevity Increase ERV2
34595 esc extra sexcombs Drosophila melanogaster Anti-Longevity 59% Increase esc
851965 ESC2 Establishment of Silent Chromatin Saccharomyces cerevisiae Necessary For Fitness 50% Decrease ESC2
34903 esg escargot Drosophila melanogaster Anti-Longevity 21% Increase esg
853971 ESL2 Est1A/B-Smg6/5-Like Saccharomyces cerevisiae Necessary For Fitness Decrease ESL2
852314 ETR1 2-Enoyl Thioester Reductase Saccharomyces cerevisiae Necessary For Fitness 45% Decrease ETR1
180927 ets-4 ETS class transcription factor Caenorhabditis elegans Anti-Longevity 40% Increase ets-4
180702 ets-9 Protein ETS-9 Caenorhabditis elegans Pro-Longevity 23% Decrease ets-9
852130 EUG1 ER protein Unnecessary for Growth Saccharomyces cerevisiae Unclear Increase and Decrease EUG1
173069 exo-3 EXOnuclease Caenorhabditis elegans Pro-Longevity 20% Decrease exo-3
854198 EXO1 EXOnuclease Saccharomyces cerevisiae Necessary For Fitness Decrease EXO1
186604 exos-3 EXOSome (multiexonuclease complex) component Caenorhabditis elegans Anti-Longevity 12% Increase exos-3
178020 F01G4.6 Phosphate carrier protein, mitochondrial Caenorhabditis elegans Anti-Longevity 12% Increase F01G4.6
176285 F02A9.4 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial Caenorhabditis elegans Anti-Longevity 13% Increase F02A9.4
177674 F08B4.7 Protein F08B4.7 Caenorhabditis elegans Anti-Longevity 21% Increase F08B4.7
175767 F09F7.3 Protein F09F7.3 Caenorhabditis elegans Anti-Longevity 8% Increase F09F7.3
175766 F09F7.4 hypothetical protein Caenorhabditis elegans Anti-Longevity 11% Increase F09F7.4
175764 F09F7.5 Protein F09F7.5 Caenorhabditis elegans Anti-Longevity Increase F09F7.5
184367 F11G11.13 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase F11G11.13
184407 F13B6.1 Protein F13B6.1 Caenorhabditis elegans Anti-Longevity 50% Increase F13B6.1
172478 F13G3.7 Protein F13G3.7 Caenorhabditis elegans Anti-Longevity 25% Increase F13G3.7
172752 F14B4.3 Protein F14B4.3 Caenorhabditis elegans Anti-Longevity 15% Increase F14B4.3
184523 F15B9.6 hypothetical protein Caenorhabditis elegans Anti-Longevity 17% Increase F15B9.6
184528 F15D3.8 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase F15D3.8
178181 F19B6.1 Protein F19B6.1 Caenorhabditis elegans Anti-Longevity 35% Increase F19B6.1
174019 F21H12.1 Protein F21H12.1 Caenorhabditis elegans Anti-Longevity Increase F21H12.1
184826 F22D3.5 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase F22D3.5
184916 F25B3.5 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase F25B3.5
172525 F26A3.4 Protein F26A3.4 Caenorhabditis elegans Anti-Longevity 27% Increase F26A3.4
259393 F26E4.4 Protein F26E4.4 Caenorhabditis elegans Anti-Longevity 17% Increase F26E4.4
3565338 F26E4.6 Protein F26E4.6 Caenorhabditis elegans Anti-Longevity 60% Increase F26E4.6
172111 F28B3.5 Protein F28B3.5 Caenorhabditis elegans Anti-Longevity 30% Increase F28B3.5
177549 F33D4.5 Protein F33D4.5 Caenorhabditis elegans Anti-Longevity 57% Increase F33D4.5
185238 F33H2.8 Protein F33H2.8 Caenorhabditis elegans Pro-Longevity 36% Decrease F33H2.8
174229 F35D2.3 Protein F35D2.3 Caenorhabditis elegans Anti-Longevity Increase F35D2.3
172692 F36A2.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 80% Increase F36A2.7
177145 F37C4.4 Protein F37C4.4 Caenorhabditis elegans Pro-Longevity Decrease F37C4.4
174702 F40F8.5 Protein F40F8.5 Caenorhabditis elegans Anti-Longevity Increase F40F8.5
185645 F42A6.1 hypothetical protein Caenorhabditis elegans Anti-Longevity 22% Increase F42A6.1
181214 F42G10.1 Protein F42G10.1 Caenorhabditis elegans Anti-Longevity Increase F42G10.1
176769 F45G2.8 Mitochondrial import inner membrane translocase subunit tim-16 Caenorhabditis elegans Pro-Longevity 8% Decrease F45G2.8
174992 F45H10.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 40% Increase F45H10.2
177752 F49C12.9 Protein F49C12.9 Caenorhabditis elegans Anti-Longevity 19% Increase F49C12.9
178381 F55B11.1 Protein F55B11.1 Caenorhabditis elegans Anti-Longevity Increase F55B11.1
178383 F55B11.3 Protein F55B11.3 Caenorhabditis elegans Anti-Longevity Increase F55B11.3
3565591 F55B11.5 Protein F55B11.5 Caenorhabditis elegans Anti-Longevity Increase F55B11.5
6418597 F56H1.7 F56H1.7 Caenorhabditis elegans Pro-Longevity 25% Decrease F56H1.7
172376 F57B10.3 Protein F57B10.3 Caenorhabditis elegans Anti-Longevity 20% Increase F57B10.3
177386 F58F9.7 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase F58F9.7
3772232 fabp fatty acid bindin protein Drosophila melanogaster Pro-Longevity 81% Increase fabp
850939 FAR10 Factor ARrest Saccharomyces cerevisiae Anti-Longevity Increase FAR10
850559 FAR7 Factor ARrest Saccharomyces cerevisiae Unclear Increase and Decrease FAR7
855044 FAR8 Factor ARrest Saccharomyces cerevisiae Anti-Longevity Increase FAR8
177819 fat-4 Delta(5) fatty acid desaturase fat-4 Caenorhabditis elegans Anti-Longevity 25% Increase fat-4
179100 fat-7 FATty acid desaturase Caenorhabditis elegans Pro-Longevity Decrease fat-7
852329 FAT1 FATty acid transporter Saccharomyces cerevisiae Necessary For Fitness Decrease FAT1
266822 fbp-1 fructose-1,6-bisphosphatase Caenorhabditis elegans Anti-Longevity Increase fbp-1
851092 FBP1 Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for gluc Saccharomyces cerevisiae Anti-Longevity Decrease FBP1
189476 fbxa-121 F-box A protein Caenorhabditis elegans Pro-Longevity Decrease fbxa-121
185954 fbxa-188 F-box A protein Caenorhabditis elegans Anti-Longevity 13% Increase fbxa-188
190489 fbxa-220 F-box A protein Caenorhabditis elegans Anti-Longevity 25% Increase fbxa-220
856175 FCY1 FluoroCYtosine resistance Saccharomyces cerevisiae Anti-Longevity Increase FCY1
856783 FCY2 FluoroCYtosine resistance Saccharomyces cerevisiae Anti-Longevity Increase FCY2
856788 FCY21 FluoroCYtosine resistance Saccharomyces cerevisiae Anti-Longevity Increase FCY21
855080 FET3 FErrous Transport Saccharomyces cerevisiae Necessary For Fitness Decrease FET3
56636 Fgf21 fibroblast growth factor 21 Mus musculus Pro-Longevity 36% Increase Fgf21
64654 Fgf23 Fibroblast growth factor 23 Mus musculus Pro-Longevity Decrease Fgf23
173525 fgt-1 Facilitated Glucose Transporter Caenorhabditis elegans Anti-Longevity 25% Increase fgt-1
31845 fh frataxin homolog Drosophila melanogaster Pro-Longevity 35% Increase fh
855392 FIG4 Factor-Induced Gene Saccharomyces cerevisiae Necessary For Fitness 30% Decrease FIG4
851708 FIN1 Filaments In between Nuclei Saccharomyces cerevisiae Necessary For Fitness 30% Decrease FIN1
854745 FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) Saccharomyces cerevisiae Unclear Increase and Decrease FIS1
177340 fkh-7 ForKHead transcription factor family Caenorhabditis elegans Anti-Longevity Increase fkh-7
851120 FLD1 Few Lipid Droplets Saccharomyces cerevisiae Necessary For Fitness Decrease FLD1
854709 FMC1 Formation of Mitochondrial Complexes Saccharomyces cerevisiae Necessary For Fitness Decrease FMC1
177958 fmo-2 Dimethylaniline monooxygenase [N-oxide-forming] Caenorhabditis elegans Pro-Longevity 20% Increase fmo-2
851642 FMP16 Found in Mitochondrial Proteome Saccharomyces cerevisiae Necessary For Fitness 40% Decrease FMP16
853923 FMP46 Found in Mitochondrial Proteome Saccharomyces cerevisiae Necessary For Fitness 20% Decrease FMP46
852270 FMT1 Formyl-Methionyl-tRNA Transformylase Saccharomyces cerevisiae Necessary For Fitness Decrease FMT1
14268 Fn1 Fibronectin 1 Mus musculus Pro-Longevity Decrease Fn1
851688 FOB1 Fob1p Saccharomyces cerevisiae Anti-Longevity 50% Increase FOB1
853878 FOX2 Fatty acid OXidation Saccharomyces cerevisiae Necessary For Fitness 30% Decrease FOX2
14235 Foxm1 Forkhead box M1 Mus musculus Pro-Longevity Decrease Foxm1
41709 foxo Forkhead box, sub-group O Drosophila melanogaster Pro-Longevity 33% Increase foxo
850675 FRE6 Ferric REductase 6 Saccharomyces cerevisiae Anti-Longevity 14% Increase FRE6
174002 frh-1 FRataxin (involved in human Friedrich's ataxia) Homolog Caenorhabditis elegans Unclear Increase and Decrease frh-1
856888 FTR1 Fe TRansporter Saccharomyces cerevisiae Necessary For Fitness Decrease FTR1
181348 ftt-2 Fourteen-Three-Three family Caenorhabditis elegans Pro-Longevity Increase and Decrease ftt-2
855866 FUM1 FUMarase Saccharomyces cerevisiae Necessary For Fitness Decrease FUM1
851196 FUN12 Function Unknown Now Saccharomyces cerevisiae Necessary For Fitness 40% Decrease FUN12
45374 fwd four wheel drive Drosophila melanogaster Pro-Longevity 9% Increase fwd
14297 Fxn frataxin Mus musculus Pro-Longevity Decrease Fxn
852638 FZF1 Five Zinc Fingers Saccharomyces cerevisiae Anti-Longevity 66% Increase FZF1
266859 fzy-1 FiZzY (CDC20 protein family) homolog Caenorhabditis elegans Anti-Longevity 25% Increase fzy-1
44819 g garnet Drosophila melanogaster Pro-Longevity Decrease g
2539 G6PD glucose-6-phosphate dehydrogenase Mus musculus Pro-Longevity 14% Increase G6PD
35646 Gadd45 CG11086 gene product from transcript CG11086-RA Drosophila melanogaster Pro-Longevity 77% Increase Gadd45
854954 GAL80 GALactose metabolism Saccharomyces cerevisiae Necessary For Fitness Decrease GAL80
181646 gas-1 General Anaesthetic Sensitivity abnormal Caenorhabditis elegans Unannotated Decrease gas-1
855355 GAS1 Glycophospholipid-Anchored Surface protein Saccharomyces cerevisiae Necessary For Fitness 20% Decrease GAS1
53581 Gclc Glutamate-cysteine ligase catalytic subunit Drosophila melanogaster Pro-Longevity 50% Increase Gclc
248194 Gclm Glutamate-cysteine ligase modifier subunit Drosophila melanogaster Pro-Longevity 24% Increase Gclm
851877 GCN2 General Control Nonderepressible Saccharomyces cerevisiae Unclear Increase and Decrease GCN2
856709 GCN4 General Control Nonderepressible Saccharomyces cerevisiae Unclear Increase and Decrease GCN4
853167 GCN5 Histone acetyltransferase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease GCN5
178237 gcy-18 Guanylyl CYclase Caenorhabditis elegans Anti-Longevity 25% Increase gcy-18
172051 gcy-28 Guanylyl CYclase Caenorhabditis elegans Anti-Longevity Increase gcy-28
191644 gcy-6 Guanylyl CYclase Caenorhabditis elegans Anti-Longevity 25% Increase gcy-6
23886 Gdf15 growth differentiation factor 15 Mus musculus Pro-Longevity 43% Increase Gdf15
178130 gdh-1 Glutamate dehydrogenase Caenorhabditis elegans Anti-Longevity 11% Increase gdh-1
851237 GDH3 Glutamate DeHydrogenase Saccharomyces cerevisiae Necessary For Fitness Decrease GDH3
178402 gdi-1 GDI (RabGDP Dissociation Inhibitor) family Caenorhabditis elegans Pro-Longevity Decrease gdi-1
180951 gei-15 GEX Interacting protein Caenorhabditis elegans Anti-Longevity 13% Increase gei-15
175195 gei-4 Protein GEI-4 Caenorhabditis elegans Pro-Longevity 27% Decrease gei-4
854380 GEP3 GEnetic interactors of Prohibitins Saccharomyces cerevisiae Necessary For Fitness Decrease GEP3
856817 GET2 Guided Entry of Tailanchored proteins Saccharomyces cerevisiae Necessary For Fitness Decrease GET2
850321 GFD2 Great for Full DEAD box protein activity Saccharomyces cerevisiae Necessary For Fitness Decrease GFD2
14599 Gh Growth hormone Mus musculus Anti-Longevity Decrease Gh
14600 Ghr Growth hormone receptor Mus musculus Anti-Longevity 40% Increase Ghr
14601 Ghrh growth hormone releasing hormone Mus musculus Anti-Longevity 46% Increase Ghrh
14602 Ghrhr Growth hormone releasing hormone receptor Mus musculus Anti-Longevity 20% Increase Ghrhr
850318 GID7 Glucose Induced Degradation deficient Saccharomyces cerevisiae Necessary For Fitness Decrease GID7
855166 GID8 Glucose Induced Degradation deficient Saccharomyces cerevisiae Necessary For Fitness Decrease GID8
40201 gig gigas Drosophila melanogaster Pro-Longevity Increase gig
852119 GIN4 Growth Inhibitory Saccharomyces cerevisiae Necessary For Fitness 35% Decrease GIN4
851670 GIS1 GIg1-2 Suppressor Saccharomyces cerevisiae Anti-Longevity 25% Increase GIS1
36447 GLaz Glial Lazarillo Drosophila melanogaster Pro-Longevity Increase and Decrease GLaz
177358 glf-1 GaLactoFuranose synthesis (UGM, UDP-galactopyranose mutase) Caenorhabditis elegans Pro-Longevity 49% Decrease glf-1
850317 GLK1 GLucoKinase Saccharomyces cerevisiae Necessary For Fitness 15% Decrease GLK1
856763 GLN3 Gln3p Saccharomyces cerevisiae Unclear Increase and Decrease GLN3
176286 glp-1 abnormal Germ Line Proliferation Caenorhabditis elegans Anti-Longevity 33% Increase glp-1
33386 GlyP Glycogen phosphorylase Drosophila melanogaster Anti-Longevity 17% Increase GlyP
41823 GlyS Glycogen synthase Drosophila melanogaster Anti-Longevity 10% Increase GlyS
851166 GMC2 Grand Meiotic recombination Cluster Saccharomyces cerevisiae Necessary For Fitness 50% Decrease GMC2
2764 GMFB glia maturation factor beta Mus musculus Anti-Longevity 6% Decrease GMFB
41561 Gnmt Glycine N-methyltransferase Drosophila melanogaster Pro-Longevity Increase Gnmt
172505 goa-1 G protein,O, Alpha subunit Caenorhabditis elegans Pro-Longevity 33% Decrease goa-1
179546 gpa-1 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity Increase and Decrease gpa-1
179075 gpa-10 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity 10% Decrease gpa-10
173759 gpa-11 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity 25% Increase gpa-11
172645 gpa-15 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity 20% Decrease gpa-15
179219 gpa-2 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity Increase and Decrease gpa-2
179319 gpa-3 G Protein, Alpha subunit Caenorhabditis elegans Pro-Longevity 15% Decrease gpa-3
180527 gpa-5 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity Increase and Decrease gpa-5
181442 gpa-6 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity 10% Increase gpa-6
179731 gpa-8 G Protein, Alpha subunit Caenorhabditis elegans Anti-Longevity Increase and Decrease gpa-8
191659 gpa-9 G Protein, Alpha subunit Caenorhabditis elegans Unannotated gpa-9
856741 GPA2 Gpa2p Saccharomyces cerevisiae Unclear Increase and Decrease GPA2
854553 GPB1 Gpb1p Saccharomyces cerevisiae Necessary For Fitness Decrease GPB1
181424 gpc-1 G Protein, Gamma subunit Caenorhabditis elegans Anti-Longevity 10% Increase gpc-1
3565504 gpd-2 GPD (glyceraldehyde 3-phosphate dehydrogenase) Caenorhabditis elegans Anti-Longevity Increase gpd-2
180601 gpd-3 Protein GPD-3 Caenorhabditis elegans Anti-Longevity 5% Increase gpd-3
33824 Gpdh Glycerol 3 phosphate dehydrogenase Drosophila melanogaster Anti-Longevity 20% Increase Gpdh
173227 gpi-1 Glucose-6-Phosphate Isomerase Caenorhabditis elegans Anti-Longevity Increase gpi-1
851527 GPR1 Gpr1p Saccharomyces cerevisiae Anti-Longevity 50% Increase GPR1
853941 GPT2 Glycerol-3-Phosphate acylTransferase Saccharomyces cerevisiae Necessary For Fitness Decrease GPT2
852546 GPX2 Glutathione PeroXidase Saccharomyces cerevisiae Necessary For Fitness 35% Decrease GPX2
625249 Gpx4 Glutathione peroxidase 4 Mus musculus Anti-Longevity 7% Increase Gpx4
38453 Gr63a Gustatory receptor 63a Drosophila melanogaster Anti-Longevity 30% Increase Gr63a
856504 GRE3 trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Saccharomyces cerevisiae Anti-Longevity 100% Increase GRE3
176843 grl-19 GRound-Like (grd related) Caenorhabditis elegans Anti-Longevity 27% Increase grl-19
176827 grld-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 10% Increase grld-1
14824 Grn granulin Mus musculus Pro-Longevity Decrease Grn
175725 gro-1 abnormal GROwth rate Caenorhabditis elegans Unannotated 29% Increase gro-1
171687 gsa-1 G protein, Subunit Alpha Caenorhabditis elegans Pro-Longevity 84% Decrease gsa-1
606496 Gsk3a glycogen synthase kinase 3 alpha Mus musculus Pro-Longevity Decrease Gsk3a
178725 gst-10 Glutathione S-Transferase Caenorhabditis elegans Pro-Longevity Increase and Decrease gst-10
187537 gst-5 Glutathione S-Transferase Caenorhabditis elegans Pro-Longevity Decrease gst-5
14860 Gsta4 glutathione S-transferase, alpha 4 Mus musculus Anti-Longevity 13% Increase Gsta4
36927 GstS1 Glutathione S transferase S1 Drosophila melanogaster Pro-Longevity 33% Increase GstS1
850962 GSY2 Glycogen SYnthase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease GSY2
854918 GTR1 GTp binding protein Resemblance 1 Saccharomyces cerevisiae Necessary For Fitness 36% Decrease GTR1
854651 GUT2 Glycerol UTilization Saccharomyces cerevisiae Pro-Longevity 25% Increase GUT2
854236 GYP1 Gtpase-activating protein for YPt1p Saccharomyces cerevisiae Necessary For Fitness Decrease GYP1
186700 H06H21.8 Protein H06H21.8 Caenorhabditis elegans Anti-Longevity Increase H06H21.8
173134 H28O16.1 Protein H28O16.1 Caenorhabditis elegans Anti-Longevity 27% Increase H28O16.1
852260 HAP3 Heme Activator Protein Saccharomyces cerevisiae Necessary For Fitness 50% Decrease HAP3
853751 HAP4 Hap4p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease HAP4
856106 HAT1 Histone AcetylTransferase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease HAT1
856654 HAT2 Hat2p Saccharomyces cerevisiae Unannotated 30% Increase HAT2
177560 hcf-1 human HCF1 related Caenorhabditis elegans Anti-Longevity 40% Increase hcf-1
850429 HCM1 Hcm1p Saccharomyces cerevisiae Pro-Longevity 30% Increase HCM1
855710 HDA1 Histone DeAcetylase Saccharomyces cerevisiae Anti-Longevity Increase HDA1
851889 HDA2 Histone DeAcetylase Saccharomyces cerevisiae Necessary For Fitness Decrease HDA2
36011 hebe hebe gene product from transcript hebe-RD Drosophila melanogaster Pro-Longevity 24% Increase hebe
174333 hel-1 Spliceosome RNA helicase DDX39B homolog Caenorhabditis elegans Pro-Longevity 9% Decrease hel-1
15201 Hells Proliferation associated SNF-2-like gene Mus musculus Pro-Longevity Decrease Hells
855338 HER2 Hmg2p ER Remodeling Saccharomyces cerevisiae Necessary For Fitness Decrease HER2
854412 HES1 Hes1p Saccharomyces cerevisiae Anti-Longevity 25% Decrease HES1
45875 Hex-A Hexokinase A Drosophila melanogaster Anti-Longevity 10% Increase Hex-A
44008 Hex-C Hexokinase C Drosophila melanogaster Anti-Longevity Increase Hex-C
855247 HFA1 acetyl-CoA carboxylase HFA1 Saccharomyces cerevisiae Necessary For Fitness Decrease HFA1
190374 hhat-2 Homolog of Hedgehog AcylTransferase Caenorhabditis elegans Anti-Longevity 50% Increase hhat-2
180359 hif-1 HIF (Hypoxia Inducible Factor) homologa Caenorhabditis elegans Unclear 34% Increase hif-1
178201 him-6 High Incidence of Males (increased X chromosome loss) Caenorhabditis elegans Pro-Longevity Decrease him-6
852275 HIR1 HIstone Regulation Saccharomyces cerevisiae Unclear Increase and Decrease HIR1
854203 HIR2 HIstone Regulation Saccharomyces cerevisiae Unclear Increase and Decrease HIR2
853605 HIR3 HIstone Regulation Saccharomyces cerevisiae Unclear Increase and Decrease HIR3
179341 his-37 Histone H4 Caenorhabditis elegans Anti-Longevity 4% Increase his-37
181057 his-71 HIStone Caenorhabditis elegans Pro-Longevity 19% Decrease his-71
852550 HIS7 HIStidine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease HIS7
35169 hk hook Drosophila melanogaster Pro-Longevity Decrease hk
181499 hlb-1 Protein HLB-1 Caenorhabditis elegans Pro-Longevity Decrease hlb-1
177157 hlh-30 Helix Loop Helix Caenorhabditis elegans Pro-Longevity 20% Increase hlh-30
176052 hmg-4 Protein HMG-4 Caenorhabditis elegans Anti-Longevity 6% Increase hmg-4
854058 HMI1 Helicase in MItochondria Saccharomyces cerevisiae Necessary For Fitness Decrease HMI1
852322 HMT1 HnRNP MethylTransferase Saccharomyces cerevisiae Anti-Longevity 50% Increase HMT1
852803 HNM1 Hyper-resistance to Nitrogen Mustard Saccharomyces cerevisiae Anti-Longevity Increase HNM1
11991 Hnrnpd heterogeneous nuclear ribonucleoprotein D Mus musculus Pro-Longevity Decrease Hnrnpd
854432 HNT3 Histidine triad NucleoTide-binding Saccharomyces cerevisiae Necessary For Fitness Decrease HNT3
32080 hop hopscotch Drosophila melanogaster Pro-Longevity Increase and Decrease hop
186781 hpa-1 hypothetical protein Caenorhabditis elegans Anti-Longevity 30% Increase hpa-1
188415 hpa-2 hypothetical protein Caenorhabditis elegans Anti-Longevity 15% Increase hpa-2
180695 hpk-1 Homeodomain interacting Protein Kinase Caenorhabditis elegans Pro-Longevity 37% Decrease hpk-1
176506 hpl-2 Protein HPL-2 Caenorhabditis elegans Anti-Longevity 17% Increase hpl-2
3565786 hpo-31 Protein HPO-31 Caenorhabditis elegans Pro-Longevity 52% Decrease hpo-31
852008 HPT1 Hypoxanthine guanine PhosphoribosylTransferase Saccharomyces cerevisiae Anti-Longevity Increase HPT1
855728 HRB1 Hypothetical RNA-Binding protein Saccharomyces cerevisiae Anti-Longevity 20% Increase HRB1
854149 HRD1 HMG-coA Reductase Degradation Saccharomyces cerevisiae Unclear Increase and Decrease HRD1
850904 HRD3 HMG-coA Reductase Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease HRD3
177101 hrp-1 human HnRNP A1 homolog Caenorhabditis elegans Anti-Longevity 49% Increase hrp-1
850786 HRT3 High level expression Reduces Ty3 transposition Saccharomyces cerevisiae Necessary For Fitness 50% Decrease HRT3
32133 Hsc70-3 Heat shock protein cognate 3 Drosophila melanogaster Pro-Longevity 27% Increase Hsc70-3
856387 HSE1 Has Symptoms of class E mutants; resembles Hbp, Stam and East Saccharomyces cerevisiae Unclear Increase and Decrease HSE1
173078 hsf-1 Heat shock transcription factor 1 Caenorhabditis elegans Pro-Longevity Increase and Decrease hsf-1
177778 hsp-12.6 Heat Shock Protein Caenorhabditis elegans Pro-Longevity 16% Decrease hsp-12.6
179286 hsp-16.1 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Increase and Decrease hsp-16.1
179287 hsp-16.48 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Increase hsp-16.48
179288 hsp-16.49 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Increase and Decrease hsp-16.49
174203 hsp-4 Heat Shock Protein Caenorhabditis elegans Pro-Longevity Decrease hsp-4
178873 hsp-6 Heat shock 70kDa protein 9B (mortalin-2) Caenorhabditis elegans Pro-Longevity Increase and Decrease hsp-6
850633 HSP104 chaperone ATPase HSP104 Saccharomyces cerevisiae Necessary For Fitness 40% Decrease HSP104
3772576 Hsp22 Heat shock protein 22 Drosophila melanogaster Unclear Increase and Decrease Hsp22
39075 Hsp26 Heat shock protein 26 Drosophila melanogaster Pro-Longevity 30% Increase Hsp26
39078 Hsp27 Heat shock protein 27 Drosophila melanogaster Pro-Longevity 30% Increase Hsp27
39071 Hsp67Bc Heat shock gene 67Bc Drosophila melanogaster Pro-Longevity 6% Increase Hsp67Bc
42852 Hsp68 Heat shock protein 68 Drosophila melanogaster Pro-Longevity 20% Increase Hsp68
hsp70 Heat Shock Protein Drosophila melanogaster Pro-Longevity Increase hsp70
44921 Hsp70Ba Heat shock 70kDa protein 1A Drosophila melanogaster Unclear Increase and Decrease Hsp70Ba
854086 HST1 Homolog of SIR Two (SIR2) Saccharomyces cerevisiae Necessary For Fitness Decrease HST1
856092 HST2 Hst2p Saccharomyces cerevisiae Pro-Longevity Increase HST2
856464 HTD2 Hydroxyacyl-Thioester Dehydratase Saccharomyces cerevisiae Necessary For Fitness Decrease HTD2
172099 htp-3 Him-Three Paralog Caenorhabditis elegans Anti-Longevity 19% Increase htp-3
15551 Htr1b 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus Pro-Longevity Decrease Htr1b
64704 Htra2 HtrA serine peptidase 2 Mus musculus Pro-Longevity Decrease Htra2
15194 Htt Huntingtin Mus musculus Anti-Longevity 18% Increase Htt
171939 hus-1 human HUS1 related Caenorhabditis elegans Anti-Longevity 11% Increase hus-1
852639 HXK2 hexokinase 2 Saccharomyces cerevisiae Anti-Longevity 50% Increase HXK2
856496 HXT5 HeXose Transporter Saccharomyces cerevisiae Necessary For Fitness Decrease HXT5
177660 hyl-1 Homolog of Yeast Longevity gene Caenorhabditis elegans Pro-Longevity 10% Decrease hyl-1
853586 IBA57 Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins Saccharomyces cerevisiae Anti-Longevity 50% Increase IBA57
856794 ICL1 IsoCitrate Lyase Saccharomyces cerevisiae Necessary For Fitness Decrease ICL1
177775 idh-1 Protein IDH-1 Caenorhabditis elegans Anti-Longevity Increase idh-1
855691 IDH1 Isocitrate DeHydrogenase Saccharomyces cerevisiae Anti-Longevity 15% Increase IDH1
854303 IDH2 Idh2p Saccharomyces cerevisiae Anti-Longevity 30% Increase IDH2
172655 idha-1 Protein IDHA-1 Caenorhabditis elegans Anti-Longevity Increase idha-1
851493 IDP1 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae Anti-Longevity 15% Increase IDP1
850871 IDP2 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae Unclear Increase and Decrease IDP2
855723 IDP3 Isocitrate Dehydrogenase, NADP-specific Saccharomyces cerevisiae Unclear Increase and Decrease IDP3
181699 ifa-3 Intermediate filament protein ifa-3 Caenorhabditis elegans Anti-Longevity Increase ifa-3
187585 ifd-1 Intermediate filament protein ifd-1 Caenorhabditis elegans Anti-Longevity Increase ifd-1
176755 ife-1 Initiation Factor 4E (eIF4E) family Caenorhabditis elegans Anti-Longevity Increase ife-1
180393 ife-2 Initiation Factor 4E (eIF4E) family Caenorhabditis elegans Anti-Longevity Increase ife-2
176373 iff-1 Initiation Factor Five (eIF-5A) homologs Caenorhabditis elegans Anti-Longevity Increase iff-1
174322 ifg-1 Initiation Factor 4G (eIF4G) family Caenorhabditis elegans Anti-Longevity 55% Increase ifg-1
181182 ifp-1 Intermediate filament protein ifp-1 Caenorhabditis elegans Anti-Longevity Increase ifp-1
189055 ifta-2 IntraFlagellar Transport Associated Caenorhabditis elegans Anti-Longevity 50% Increase ifta-2
172584 iftb-1 eIFTwoBeta (eIF2beta translation initiation factor) Caenorhabditis elegans Anti-Longevity Increase iftb-1
16000 Igf1 Insulin-like growth factor 1 Mus musculus Unclear Increase and Decrease Igf1
16001 Igf1r Insulin-like growth factor 1 receptor Mus musculus Anti-Longevity 40% Increase Igf1r
16150 Ikbkb inhibitor of kappaB kinase beta Mus musculus Anti-Longevity 23% Increase Ikbkb
851100 IKI3 Insensitive to KIller toxin Saccharomyces cerevisiae Anti-Longevity Increase IKI3
53573 Ilk Integrin linked kinase Drosophila melanogaster Anti-Longevity 63% Increase Ilk
39150 Ilp2 Insulin-related peptide Drosophila melanogaster Anti-Longevity 47% Increase Ilp2
31220 Ilp6 Insulin-like peptide 6 Drosophila melanogaster Pro-Longevity 16% Increase Ilp6
850413 IMG1 mitochondrial 54S ribosomal protein IMG1 Saccharomyces cerevisiae Anti-Longevity 23% Increase IMG1
850434 IMG2 mitochondrial 54S ribosomal protein IMG2 Saccharomyces cerevisiae Anti-Longevity 28% Increase IMG2
38513 ImpL2 Ecdysone-inducible gene L2 Drosophila melanogaster Pro-Longevity 23% Increase ImpL2
173001 impt-1 Protein IMPACT homolog Caenorhabditis elegans Anti-Longevity 16% Increase impt-1
32343 inaE inactivation no afterpotential E Drosophila melanogaster Pro-Longevity 73% Increase inaE
40049 Indy I'm not dead yet protein Drosophila melanogaster Anti-Longevity 92% Increase Indy
175966 inf-1 INitiation Factor Caenorhabditis elegans Unclear Increase and Decrease inf-1
856442 INM1 INositol Monophosphatase Saccharomyces cerevisiae Unclear Increase and Decrease INM1
851881 INM2 INositol Monophosphatase Saccharomyces cerevisiae Necessary For Fitness 70% Decrease INM2
854042 INO4 INOsitol requiring Saccharomyces cerevisiae Necessary For Fitness Decrease INO4
854815 INP51 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae Anti-Longevity 10% Increase INP51
854276 INP53 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease INP53
854089 INP54 INositol polyphosphate 5-Phosphatase Saccharomyces cerevisiae Unclear Increase and Decrease INP54
42549 InR Insulin-like 1 receptor Drosophila melanogaster Anti-Longevity 85% Increase InR
177936 ins-1 INSulin related Caenorhabditis elegans Pro-Longevity 25% Increase ins-1
172600 ins-18 INSulin related Caenorhabditis elegans Anti-Longevity Increase ins-18
191689 ins-21 INSulin related Caenorhabditis elegans Anti-Longevity Increase ins-21
191688 ins-7 INSulin related Caenorhabditis elegans Anti-Longevity 12% Increase ins-7
16337 Insr Insulin receptor Mus musculus Anti-Longevity 33% Increase Insr
172488 inx-14 INneXin Caenorhabditis elegans Anti-Longevity Increase inx-14
178101 inx-8 INneXin Caenorhabditis elegans Anti-Longevity 19% Increase inx-8
191694 inx-9 INneXin Caenorhabditis elegans Anti-Longevity 28% Increase inx-9
851910 IPK1 Inositol Polyphosphate Kinase Saccharomyces cerevisiae Anti-Longevity 40% Increase IPK1
851644 IPT1 InositolPhosphoTransferase Saccharomyces cerevisiae Unclear Increase and Decrease IPT1
174305 ire-1 IRE1 kinase related Caenorhabditis elegans Pro-Longevity 20% Decrease ire-1
42358 Ire1 Inositol-requiring enzyme-1 Drosophila melanogaster Pro-Longevity Decrease Ire1
16367 Irs1 insulin receptor substrate 1 Mus musculus Anti-Longevity 18% Increase Irs1
384783 Irs2 insulin receptor substrate 2 Mus musculus Anti-Longevity 18% Increase Irs2
856739 ISC1 Inositol phosphoSphingolipid phospholipase C Saccharomyces cerevisiae Pro-Longevity Decrease ISC1
856067 ISM1 Isoleucyl tRNA Synthetase of Mitochondria Saccharomyces cerevisiae Unclear Increase and Decrease ISM1
177609 isp-1 Iron-Sulfur Protein Caenorhabditis elegans Anti-Longevity 60% Increase isp-1
852547 ISW1 Imitation SWitch subfamily Saccharomyces cerevisiae Unclear Increase and Decrease ISW1
854480 ISW2 Isw2p Saccharomyces cerevisiae Anti-Longevity 24% Increase ISW2
852744 ITC1 Itc1p Saccharomyces cerevisiae Anti-Longevity 18% Increase ITC1
177546 itr-1 Inositol Triphosphate Receptor Caenorhabditis elegans Pro-Longevity 53% Increase itr-1
850710 IZH3 Implicated in Zinc Homeostasis Saccharomyces cerevisiae Necessary For Fitness Decrease IZH3
53578 Jafrac1 Thioredoxin peroxidase 1 Drosophila melanogaster Pro-Longevity 29% Increase Jafrac1
34624 JhI-21 CG12317-PA Drosophila melanogaster Anti-Longevity 32% Increase JhI-21
856174 JID1 DnaJ protein Involved in ER-associated Degradation Saccharomyces cerevisiae Necessary For Fitness Decrease JID1
180810 jkk-1 JNK Kinase Caenorhabditis elegans Unannotated Decrease jkk-1
175080 jmjd-2 Lysine-specific demethylase 4 Caenorhabditis elegans Anti-Longevity 13% Increase jmjd-2
177460 jnk-1 Jun N-terminal Kinase Caenorhabditis elegans Pro-Longevity Increase and Decrease jnk-1
855339 JNM1 Just Nuclear Migration Saccharomyces cerevisiae Necessary For Fitness Decrease JNM1
16478 Jund Jun proto-oncogene related gene d Mus musculus Pro-Longevity 17% Decrease Jund
186841 K01C8.7 Protein K01C8.7 Caenorhabditis elegans Anti-Longevity 20% Increase K01C8.7
177624 K07H8.1 Protein K07H8.1 Caenorhabditis elegans Anti-Longevity Increase K07H8.1
187128 K07H8.8 Protein K07H8.8 Caenorhabditis elegans Anti-Longevity 22% Increase K07H8.8
176814 K08E3.5 Protein K08E3.5 Caenorhabditis elegans Anti-Longevity Increase K08E3.5
173397 K10B4.3 Protein K10B4.3 Caenorhabditis elegans Anti-Longevity Increase K10B4.3
173349 K11B4.1 Protein K11B4.1 Caenorhabditis elegans Anti-Longevity 16% Increase K11B4.1
178892 K11D12.9 Protein K11D12.9 Caenorhabditis elegans Pro-Longevity Decrease K11D12.9
187337 K12H4.5 Protein K12H4.5 Caenorhabditis elegans Anti-Longevity 58% Increase K12H4.5
856263 KAR3 KARyogamy Saccharomyces cerevisiae Anti-Longevity 55% Increase KAR3
174161 kat-1 3-Ketoacyl-coA Thiolase Caenorhabditis elegans Pro-Longevity 30% Decrease kat-1
16491 Kcna3 Potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus Anti-Longevity 22% Increase Kcna3
42062 Keap1 CG3962 gene product from transcript CG3962-RA Drosophila melanogaster Anti-Longevity 10% Increase Keap1
46027 kermit CG11546 Drosophila melanogaster Pro-Longevity 30% Decrease kermit
855483 KEX2 Killer EXpression defective Saccharomyces cerevisiae Necessary For Fitness Decrease KEX2
854681 KGD1 alpha-KetoGlutarate Dehydrogenase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease KGD1
16591 Kl Klotho Mus musculus Pro-Longevity Increase and Decrease Kl
175404 klf-1 Kruppel-Like Factor (zinc finger protein) Caenorhabditis elegans Pro-Longevity 15% Increase klf-1
177557 klo-1 hypothetical protein Caenorhabditis elegans Pro-Longevity 15% Decrease klo-1
184000 klo-2 hypothetical protein Caenorhabditis elegans Pro-Longevity 15% Decrease klo-2
40680 kra krasavietz Drosophila melanogaster Anti-Longevity 25% Increase kra
191275 kri-1 human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog Caenorhabditis elegans Pro-Longevity Decrease kri-1
2539653 ksp1 serine/threonine protein kinase Ksp1 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase ksp1
852931 KSS1 Kss1p Saccharomyces cerevisiae Necessary For Fitness 33% Decrease KSS1
42063 kuk kugelkern Drosophila melanogaster Anti-Longevity Decrease kuk
249462 l(3)DTS3 lethal (3) DTS3 Drosophila melanogaster Anti-Longevity 42% Increase l(3)DTS3
46260 l(3)neo18 l(3)neo18 Drosophila melanogaster Anti-Longevity 24% Increase l(3)neo18
856386 LAG1 Ceramide synthase component Saccharomyces cerevisiae Anti-Longevity 50% Increase LAG1
854133 LAG2 Lag2p Saccharomyces cerevisiae Pro-Longevity 36% Increase LAG2
189370 lagr-1 LAG1 (yeast Longevity-Assurance Gene) Related Caenorhabditis elegans Pro-Longevity 10% Decrease lagr-1
172499 lars-2 Leucyl Amino-acyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity Increase lars-2
853384 LAS21 Local Anestheticum Sensitive Saccharomyces cerevisiae Necessary For Fitness Decrease LAS21
855653 LAT1 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes Saccharomyces cerevisiae Pro-Longevity 20% Increase LAT1
179161 lbp-4 Lipid Binding Protein Caenorhabditis elegans Pro-Longevity Decrease lbp-4
172390 lbp-6 Lipid Binding Protein Caenorhabditis elegans Unclear Increase and Decrease lbp-6
191701 lbp-7 Lipid Binding Protein Caenorhabditis elegans Anti-Longevity Increase lbp-7
188761 lbp-8 Lipid Binding Protein Caenorhabditis elegans Pro-Longevity 30% Increase lbp-8
178686 lbp-9 Lipid Binding Protein Caenorhabditis elegans Pro-Longevity Decrease lbp-9
37482 LBR Lamin B receptor Drosophila melanogaster Anti-Longevity Decrease LBR
853307 LCB3 Long-Chain Base Saccharomyces cerevisiae Anti-Longevity Increase LCB3
856051 LCL1 Long Chronological Lifespan Saccharomyces cerevisiae Anti-Longevity Increase LCL1
850794 LCL2 Long Chronological Lifespan 2 Saccharomyces cerevisiae Anti-Longevity Increase LCL2
852795 LCL3 Long Chronological Lifespan 3 Saccharomyces cerevisiae Anti-Longevity Increase LCL3
181292 ldb-1 LIM domain Binding Protein Caenorhabditis elegans Pro-Longevity Decrease ldb-1
850351 LDB16 Low Dye Binding Saccharomyces cerevisiae Necessary For Fitness Decrease LDB16
854500 LDB19 Low Dye Binding Saccharomyces cerevisiae Necessary For Fitness Decrease LDB19
175058 lem-2 LEM domain protein Caenorhabditis elegans Pro-Longevity Decrease lem-2
174462 let-23 LEThal Caenorhabditis elegans Pro-Longevity Increase and Decrease let-23
172167 let-363 LEThal Caenorhabditis elegans Anti-Longevity 150% Increase let-363
178970 let-418 Protein let-418 Caenorhabditis elegans Anti-Longevity 25% Increase let-418
172088 let-502 LEThal Caenorhabditis elegans Pro-Longevity 30% Decrease let-502
178104 let-60 LEThal Caenorhabditis elegans Unannotated Increase let-60
172153 let-630 hypothetical protein Caenorhabditis elegans Anti-Longevity 18% Increase let-630
178120 let-653 LEThal Caenorhabditis elegans Pro-Longevity 13% Decrease let-653
175934 let-765 LEThal Caenorhabditis elegans Pro-Longevity 27% Decrease let-765
179854 letm-1 LETM1 (Leucine zipper, EF-hand, TransMembrane mitochondrial protein) homolog Caenorhabditis elegans Anti-Longevity 21% Increase letm-1
850342 LEU2 LEUcine biosynthesis Saccharomyces cerevisiae Anti-Longevity Increase LEU2
851172 LEU3 LEUcine biosynthesis Saccharomyces cerevisiae Anti-Longevity Increase LEU3
174050 lgg-1 LC3, GABARAP and GATE-16 family Caenorhabditis elegans Pro-Longevity 43% Decrease lgg-1
853789 LHS1 Lumenal Hsp Seventy Saccharomyces cerevisiae Necessary For Fitness 50% Decrease LHS1
172893 lin-11 Protein LIN-11 Caenorhabditis elegans Pro-Longevity 9% Decrease lin-11
181337 lin-14 abnormal cell LINeage Caenorhabditis elegans Anti-Longevity 31% Increase lin-14
181662 lin-15B abnormal cell LINeage Caenorhabditis elegans Pro-Longevity 42% Decrease lin-15B
181400 lin-2 abnormal cell LINeage Caenorhabditis elegans Unclear Increase lin-2
174058 lin-23 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity Decrease lin-23
172626 lin-28 Protein lin-28 Caenorhabditis elegans Anti-Longevity 20% Increase lin-28
178001 lin-3 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity Decrease lin-3
266860 lin-4 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity lin-4
178788 lin-40 abnormal cell LINeage Caenorhabditis elegans Pro-Longevity Increase and Decrease lin-40
174267 lin-5 Protein LIN-5 Caenorhabditis elegans Anti-Longevity 16% Increase lin-5
171739 lin-65 hypothetical protein Caenorhabditis elegans Pro-Longevity 24% Decrease lin-65
856561 LIN1 LINk Saccharomyces cerevisiae Anti-Longevity 40% Increase LIN1
191704 lip-1 Lateral-signal-Induced Phosphatase Caenorhabditis elegans Anti-Longevity 8% Increase lip-1
850940 LIP2 LIPoyl ligase Saccharomyces cerevisiae Necessary For Fitness Decrease LIP2
179046 lipl-4 LIPase Like Caenorhabditis elegans Pro-Longevity 55% Increase lipl-4
172687 lmn-1 nuclear LaMiN Caenorhabditis elegans Pro-Longevity 12% Decrease lmn-1
16905 Lmna lamin A Mus musculus Unclear Increase and Decrease Lmna
43130 Lnk CG17367 gene product from transcript CG17367-RC Drosophila melanogaster Anti-Longevity 33% Increase Lnk
850551 LOC1 LOCalization of ASH1 mRNA Saccharomyces cerevisiae Anti-Longevity 40% Increase LOC1
42672 loco locomotion defects Drosophila melanogaster Anti-Longevity Increase and Decrease loco
853630 LOS1 Loss Of Suppression Saccharomyces cerevisiae Necessary For Fitness Decrease LOS1
172037 lpd-5 LiPid Depleted Caenorhabditis elegans Anti-Longevity 17% Increase lpd-5
179477 lpd-9 LiPid Depleted Caenorhabditis elegans Anti-Longevity 10% Increase lpd-9
850527 LPD1 LiPoamide Dehydrogenase Saccharomyces cerevisiae Necessary For Fitness Decrease LPD1
181297 lpr-5 Protein LPR-5 Caenorhabditis elegans Pro-Longevity 16% Decrease lpr-5
853037 LSB1 Las Seventeen Binding protein Saccharomyces cerevisiae Anti-Longevity 30% Increase LSB1
850580 LSB3 Las Seventeen Binding protein Saccharomyces cerevisiae Anti-Longevity 40% Increase LSB3
853345 LSB6 Las Seventeen Binding protein Saccharomyces cerevisiae Anti-Longevity 50% Increase LSB6
854310 LSC1 succinate--CoA ligase (GDP-forming) subunit alpha Saccharomyces cerevisiae Necessary For Fitness Decrease LSC1
853159 LSC2 succinate--CoA ligase (GDP-forming) subunit beta Saccharomyces cerevisiae Necessary For Fitness Decrease LSC2
177988 lsm-7 LSM Sm-like protein Caenorhabditis elegans Pro-Longevity 24% Decrease lsm-7
851984 LSM6 Like SM Saccharomyces cerevisiae Necessary For Fitness Decrease LSM6
852948 LST7 Lethal with Sec Thirteen Saccharomyces cerevisiae Necessary For Fitness 40% Decrease LST7
3355130 lt light Drosophila melanogaster Pro-Longevity Decrease lt
184622 lys-10 LYSozyme Caenorhabditis elegans Anti-Longevity 20% Increase lys-10
178087 lys-6 LYSozyme Caenorhabditis elegans Anti-Longevity 13% Increase lys-6
173944 lys-8 LYSozyme Caenorhabditis elegans Pro-Longevity 29% Decrease lys-8
854852 LYS1 LYSine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease LYS1
854714 LYS12 Isocitrate dehydrogenase Saccharomyces cerevisiae Anti-Longevity Increase LYS12
2542118 lys7 alpha-aminoadipate reductase phosphopantetheinyl transferase Lys7 Schizosaccharomyces pombe Anti-Longevity Increase lys7
855786 LYS9 LYSine requiring Saccharomyces cerevisiae Unclear Increase and Decrease LYS9
187451 M05B5.2 Protein M05B5.2 Caenorhabditis elegans Pro-Longevity 45% Decrease M05B5.2
177113 M57.2 Protein M57.2 Caenorhabditis elegans Pro-Longevity 20% Decrease M57.2
33529 Mad Mothers against dpp Drosophila melanogaster Pro-Longevity 22% Decrease Mad
853422 MAD2 Mitotic Arrest-Deficient Saccharomyces cerevisiae Anti-Longevity 50% Increase MAD2
173073 mag-1 Drosophila MAGonashi homolog Caenorhabditis elegans Pro-Longevity 15% Decrease mag-1
36048 magu magu gene product from transcript magu -RD Drosophila melanogaster Pro-Longevity 5% Increase magu
856657 MAK10 MAintenance of Killer Saccharomyces cerevisiae Necessary For Fitness Decrease MAK10
856163 MAK3 MAintenance of Killer Saccharomyces cerevisiae Necessary For Fitness Decrease MAK3
852600 MAL33 MALtose fermentation Saccharomyces cerevisiae Necessary For Fitness Decrease MAL33
174181 maoc-1 MAO-C-like dehydratase domain Caenorhabditis elegans Anti-Longevity Increase maoc-1
178089 mars-1 Methionyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity 23% Increase mars-1
179794 max-1 Motor AXon guidance Caenorhabditis elegans Anti-Longevity Increase max-1
3565400 max-2 Motor AXon guidance Caenorhabditis elegans Anti-Longevity 25% Increase max-2
852483 MBA1 Multi-copy Bypass of AFG3 Saccharomyces cerevisiae Unclear Increase and Decrease MBA1
181681 mboa-1 Protein MBOA-1 Caenorhabditis elegans Pro-Longevity 16% Decrease mboa-1
854372 MCA1 Ca(2+)-dependent cysteine protease MCA1 Saccharomyces cerevisiae Pro-Longevity 56% Increase MCA1
854483 MCH5 MonoCarboxylate transporter Homologue Saccharomyces cerevisiae Necessary For Fitness Decrease MCH5
174841 mcm-2 yeast MCM (licensing factor) related Caenorhabditis elegans Unclear Increase and Decrease mcm-2
17216 Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) Mus musculus Pro-Longevity Decrease Mcm2
179041 mdh-1 Malate DeHydrogenase Caenorhabditis elegans Anti-Longevity 4% Increase mdh-1
175936 mdh-2 Malate DeHydrogenase Caenorhabditis elegans Pro-Longevity 10% Decrease mdh-2
853777 MDH1 Malate DeHydrogenase Saccharomyces cerevisiae Pro-Longevity 25% Increase MDH1
853994 MDH2 Malate DeHydrogenase Saccharomyces cerevisiae Pro-Longevity 15% Increase MDH2
180942 mdl-1 MAD-Like Caenorhabditis elegans Anti-Longevity 16% Increase mdl-1
854079 MDM20 Mitochondrial Distribution and Morphology Saccharomyces cerevisiae Necessary For Fitness Decrease MDM20
175817 mdt-15 Mediator of RNA polymerase II transcription subunit 15 Caenorhabditis elegans Pro-Longevity 34% Decrease mdt-15
173960 mdt-26 Protein MDT-26 Caenorhabditis elegans Pro-Longevity Decrease mdt-26
172771 mec-8 MEChanosensory abnormality Caenorhabditis elegans Unannotated Increase mec-8
852433 MEC1 Mec1p Saccharomyces cerevisiae Necessary For Fitness 66% Decrease MEC1
174963 mecr-1 Protein MECR-1 Caenorhabditis elegans Anti-Longevity Increase mecr-1
856183 MED1 MEDiator complex Saccharomyces cerevisiae Necessary For Fitness Decrease MED1
171872 mek-2 Dual specificity mitogen-activated protein kinase kinase mek-2 Caenorhabditis elegans Pro-Longevity 10% Decrease mek-2
175634 mel-28 Protein MEL-28 Caenorhabditis elegans Anti-Longevity 6% Increase mel-28
47173 Men Malic enzyme Drosophila melanogaster Pro-Longevity 45% Increase Men
178074 mep-1 Mog interacting, Ectopic P granules Caenorhabditis elegans Pro-Longevity 8% Decrease mep-1
855580 MEP2 Mep2p Saccharomyces cerevisiae Anti-Longevity Increase MEP2
856260 MEP3 Mep3p Saccharomyces cerevisiae Anti-Longevity Increase MEP3
181362 mes-1 Maternal Effect Sterile Caenorhabditis elegans Anti-Longevity 60% Increase mes-1
175096 mes-2 Histone-lysine N-methyltransferase mes-2 Caenorhabditis elegans Anti-Longevity 6% Increase mes-2
176183 met-2 Histone-lysine N-methyltransferase met-2 Caenorhabditis elegans Pro-Longevity 23% Decrease met-2
853869 MET14 adenylyl-sulfate kinase Saccharomyces cerevisiae Anti-Longevity Increase MET14
856296 MET16 phosphoadenylyl-sulfate reductase (thioredoxin) Saccharomyces cerevisiae Anti-Longevity Increase MET16
851010 MET17 bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 Saccharomyces cerevisiae Anti-Longevity 100% Increase MET17
855444 MET2 METhionine requiring Saccharomyces cerevisiae Unclear Increase and Decrease MET2
853602 MET5 sulfite reductase (NADPH) subunit beta Saccharomyces cerevisiae Necessary For Fitness Decrease MET5
856825 MET6 METhionine requiring Saccharomyces cerevisiae Necessary For Fitness Decrease MET6
260040 mev-1 Abnormal MEthyl Viologen sensitivity Caenorhabditis elegans Pro-Longevity Decrease mev-1
174752 mfn-1 Protein MFN-1 Caenorhabditis elegans Anti-Longevity 64% Increase mfn-1
107895 Mgat5 mannoside acetylglucosaminyltransferase 5 Mus musculus Pro-Longevity Decrease Mgat5
853408 MHP1 MAP-Homologous Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MHP1
179475 mics-1 MItoChondrial Scaffolding protei Caenorhabditis elegans Anti-Longevity 54% Increase mics-1
17319 Mif macrophage migration inhibitory factor Mus musculus Anti-Longevity 16% Increase Mif
852848 MIG1 transcription factor MIG1 Saccharomyces cerevisiae Anti-Longevity Decrease MIG1
3565990 mir-124 Caenorhabditis elegans Pro-Longevity 16% Increase mir-124
12798013 mir-125 mir-125 stem loop Drosophila melanogaster Pro-Longevity Decrease mir-125
12798384 mir-14 mir-14 stem loop Drosophila melanogaster Pro-Longevity Decrease mir-14
3565806 mir-238 Caenorhabditis elegans Pro-Longevity 19% Decrease mir-238
3564977 mir-239.1 Caenorhabditis elegans Anti-Longevity 20% Increase mir-239.1
3565660 mir-246 Caenorhabditis elegans Pro-Longevity 10% Decrease mir-246
12798086 mir-277 mir-277 stem loop Drosophila melanogaster Anti-Longevity 70% Increase mir-277
260162 mir-34 Caenorhabditis elegans Anti-Longevity 62% Increase mir-34
12798087 mir-34 mir-34 stem loop Drosophila melanogaster Pro-Longevity Decrease mir-34
260100 mir-71 Caenorhabditis elegans Pro-Longevity 48% Decrease mir-71
3565575 mir-80 Caenorhabditis elegans Anti-Longevity Increase mir-80
853540 MIR1 Mir1p Saccharomyces cerevisiae Anti-Longevity 25% Increase MIR1
723905 Mir17 microRNA 17 Mus musculus Pro-Longevity 16% Increase Mir17
387222 Mir29a microRNA 29a Mus musculus Unannotated Mir29a
387223 Mir29b-1 microRNA 29b-1 Mus musculus Unannotated Mir29b-1
177238 miro-1 Mitochondrial Rho GTPase 1 Caenorhabditis elegans Anti-Longevity 50% Increase miro-1
852378 MIS1 MItochondrial C1-tetrahydrofolate Synthase Saccharomyces cerevisiae Necessary For Fitness Decrease MIS1
185682 mkk-4 MKK (MAP Kinase Kinase) homolog Caenorhabditis elegans Anti-Longevity Decrease mkk-4
854406 MKK1 Mitogen-activated protein Kinase-Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease MKK1
855648 MKS1 Multicopy Kinase Suppressor Saccharomyces cerevisiae Unclear Increase and Decrease MKS1
35523 mle Maleless Drosophila melanogaster Pro-Longevity 48% Decrease mle
40849 Mlp84B Muscle LIM protein at 84B Drosophila melanogaster Pro-Longevity 35% Decrease Mlp84B
176050 mml-1 Myc and Mondo-Like Caenorhabditis elegans Pro-Longevity 10% Decrease mml-1
854532 MNE1 Mne1p Saccharomyces cerevisiae Necessary For Fitness Decrease MNE1
174623 mnk-1 MAP kinase iNtegrating Kinase (MNK) homolog Caenorhabditis elegans Pro-Longevity Decrease mnk-1
856718 MNN1 alpha-1,3-mannosyltransferase MNN1 Saccharomyces cerevisiae Anti-Longevity 15% Increase MNN1
852303 MNN2 alpha-1,2-mannosyltransferase MNN2 Saccharomyces cerevisiae Anti-Longevity 16% Increase MNN2
853595 MNS1 Mns1p Saccharomyces cerevisiae Anti-Longevity Increase MNS1
31331 Mnt CG13316-PC, isoform C Drosophila melanogaster Pro-Longevity Increase and Decrease Mnt
2543646 moc3 transcription factor Moc3 Schizosaccharomyces pombe Anti-Longevity Increase moc3
171879 mod-5 Modulation Of locomotion Defective Caenorhabditis elegans Pro-Longevity Decrease mod-5
852231 MOH1 Moh1p Saccharomyces cerevisiae Necessary For Fitness Decrease MOH1
855420 MON2 MONensin sensitivity Saccharomyces cerevisiae Necessary For Fitness Decrease MON2
852800 MPC1 Mpc1p Saccharomyces cerevisiae Necessary For Fitness Decrease MPC1
854462 MPD1 protein disulfide isomerase MPD1 Saccharomyces cerevisiae Anti-Longevity 17% Increase MPD1
175545 mpk-1 MAP Kinase Caenorhabditis elegans Pro-Longevity 16% Decrease mpk-1
42866 Mpk2 CG5475-PA Drosophila melanogaster Pro-Longevity 40% Decrease Mpk2
852697 MPT5 Mpt5p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease MPT5
174657 mpz-1 Multiple PDZ domain protein Caenorhabditis elegans Anti-Longevity 31% Increase mpz-1
177736 mpz-2 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity Increase mpz-2
855264 MRE11 Meiotic REcombination Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MRE11
852816 MRH4 Mitochondrial RNA Helicase Saccharomyces cerevisiae Necessary For Fitness Decrease MRH4
181587 mrp-5 Multidrug Resistance Protein family Caenorhabditis elegans Anti-Longevity Increase mrp-5
851948 MRP1 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MRP1
856295 MRP2 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MRP2
41387 Mrp4 Multidrug resistance protein 4 ortholog Drosophila melanogaster Pro-Longevity Increase and Decrease Mrp4
855985 MRP51 Mitochondrial Ribosomal Protein Saccharomyces cerevisiae Necessary For Fitness Decrease MRP51
186840 mrpl-10 Protein MRPL-10 Caenorhabditis elegans Anti-Longevity 17% Increase mrpl-10
176495 mrpl-12 Protein MRPL-12 Caenorhabditis elegans Anti-Longevity 51% Increase mrpl-12
176903 mrpl-2 Protein MRPL-2 Caenorhabditis elegans Anti-Longevity 54% Increase mrpl-2
172204 mrpl-24 Protein MRPL-24 Caenorhabditis elegans Anti-Longevity 14% Increase mrpl-24
175001 mrpl-37 Protein MRPL-37 Caenorhabditis elegans Anti-Longevity 41% Increase mrpl-37
172164 mrpl-47 Protein MRPL-47 Caenorhabditis elegans Anti-Longevity 20% Increase mrpl-47
174422 mrpl-50 Protein MRPL-50 Caenorhabditis elegans Anti-Longevity 17% Increase mrpl-50
851325 MRPL11 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL11
855469 MRPL17 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL17
853960 MRPL20 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL20
855544 MRPL22 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL22
855231 MRPL24 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL24
850359 MRPL32 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL32
855330 MRPL33 mitochondrial 54S ribosomal protein YmL33 Saccharomyces cerevisiae Anti-Longevity 16% Increase MRPL33
853684 MRPL38 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL38
855002 MRPL39 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness 20% Decrease MRPL39
851160 MRPL4 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Unclear Increase and Decrease MRPL4
855930 MRPL40 mitochondrial 54S ribosomal protein YmL40 Saccharomyces cerevisiae Anti-Longevity 21% Increase MRPL40
853349 MRPL49 mitochondrial 54S ribosomal protein YmL49 Saccharomyces cerevisiae Anti-Longevity 25% Increase MRPL49
853135 MRPL9 Mitochondrial Ribosomal Protein, Large subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPL9
189618 mrps-10 Protein MRPS-10 Caenorhabditis elegans Anti-Longevity 39% Increase mrps-10
172957 mrps-30 Temporarily Assigned Gene name Caenorhabditis elegans Anti-Longevity 21% Increase mrps-30
184770 mrps-33 Protein MRPS-33 Caenorhabditis elegans Anti-Longevity 36% Increase mrps-33
179721 mrps-5 Protein MRPS-5 Caenorhabditis elegans Anti-Longevity 60% Increase mrps-5
184267 mrps-9 Protein MRPS-9 Caenorhabditis elegans Anti-Longevity 60% Increase mrps-9
856094 MRPS16 Mitochondrial Ribosomal Protein, Small subunit Saccharomyces cerevisiae Necessary For Fitness Decrease MRPS16
854511 MRS2 Mitochondrial RNA Splicing Saccharomyces cerevisiae Necessary For Fitness Decrease MRS2
853926 MRS4 Mitochondrial RNA Splicing Saccharomyces cerevisiae Necessary For Fitness 40% Decrease MRS4
853860 MRT4 mRNA Turnover 4 Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MRT4
851692 MRX14 putative mitochondrial 54S ribosomal protein Saccharomyces cerevisiae Anti-Longevity 12% Increase MRX14
17685 Msh2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) Mus musculus Pro-Longevity Decrease Msh2
854063 MSH2 MutS Homolog Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MSH2
851671 MSH6 MutS Homolog Saccharomyces cerevisiae Necessary For Fitness 50% Decrease MSH6
855651 MSK1 lysine--tRNA ligase MSK1 Saccharomyces cerevisiae Anti-Longevity 12% Increase MSK1
110265 Msra Methionine sulfoxide reductase A Mus musculus Pro-Longevity Decrease Msra
851775 MSS116 Mitochondrial Splicing System Saccharomyces cerevisiae Necessary For Fitness Decrease MSS116
856253 MSS18 Mitochondrial Splicing System Saccharomyces cerevisiae Necessary For Fitness Decrease MSS18
17700 Mstn myostatin Mus musculus Anti-Longevity 15% Increase Mstn
851861 MSW1 Mitochondrial aminoacyl-tRNA Synthetase, tryptophan (W) Saccharomyces cerevisiae Unclear Increase and Decrease MSW1
17748 Mt1 metallothionein 1 Mus musculus Pro-Longevity 14% Increase Mt1
34632 Mt2 DNA methyltransferase 2 Drosophila melanogaster Pro-Longevity Increase Mt2
105837 Mtbp Mdm2, transformed 3T3 cell double minute p53 binding protein Mus musculus Anti-Longevity 20% Increase Mtbp
853319 MTC1 Maintenance of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness Decrease MTC1
852557 MTC4 Mtc4p Saccharomyces cerevisiae Unclear Increase and Decrease MTC4
851706 MTC5 Maintenance of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness 35% Decrease MTC5
856678 MTC7 Maintenance of Telomere Capping Saccharomyces cerevisiae Necessary For Fitness Decrease MTC7
174207 mtch-1 Protein MTCH-1 Caenorhabditis elegans Anti-Longevity 21% Increase mtch-1
853955 MTD1 Methylene Tetrahydrafolate Dehydrogenase Saccharomyces cerevisiae Anti-Longevity Increase MTD1
39089 MTF-1 Metal response element-binding Transcription Factor-1 Drosophila melanogaster Pro-Longevity 40% Increase MTF-1
38058 mth methuselah Drosophila melanogaster Unclear 35% Increase mth
179899 mtl-2 MeTaLlothionein Caenorhabditis elegans Anti-Longevity Increase mtl-2
175490 mtm-3 MTM (myotubularin) famil Caenorhabditis elegans Pro-Longevity Decrease mtm-3
853173 MTM1 Manganese Trafficking factor for Mitochondrial SOD2 Saccharomyces cerevisiae Unclear Increase and Decrease MTM1
852616 MTO1 Mitochondrial Translation Optimization Saccharomyces cerevisiae Necessary For Fitness Decrease MTO1
56717 Mtor mechanistic target of rapamycin (serine/threonine kinase) Mus musculus Anti-Longevity 20% Increase Mtor
40436 mub mushroom-body expressed Drosophila melanogaster Anti-Longevity 21% Increase mub
855126 MUB1 Mub1p Saccharomyces cerevisiae Anti-Longevity 29% Increase MUB1
2540673 mug80 cyclin Clg1 (predicted) Schizosaccharomyces pombe Anti-Longevity Increase mug80
852348 MUM2 MUddled Meiosis Saccharomyces cerevisiae Anti-Longevity Increase MUM2
175863 mvk-1 Y42G9A.4b Caenorhabditis elegans Pro-Longevity 14% Decrease mvk-1
175184 mxl-2 MaX-Like Caenorhabditis elegans Pro-Longevity 7% Decrease mxl-2
856765 MXR1 Mxr1p Saccharomyces cerevisiae Pro-Longevity Increase and Decrease MXR1
17869 Myc myelocytomatosis oncogene Mus musculus Anti-Longevity 21% Increase Myc
43811 myo myoglianin Drosophila melanogaster Pro-Longevity 25% Increase myo
44885 mys myospheroid Drosophila melanogaster Anti-Longevity 44% Increase mys
42348 Naam Naam gene product from transcript Naam-RA Drosophila melanogaster Pro-Longevity 30% Increase Naam
187898 nac-2 NADC (Na+-coupled dicarboxylate transporter) family Caenorhabditis elegans Anti-Longevity 19% Increase nac-2
176429 nac-3 NADC (Na+-coupled dicarboxylate transporter) family Caenorhabditis elegans Anti-Longevity 15% Increase nac-3
851098 NAM2 Nuclear Accommodation of Mitochondria Saccharomyces cerevisiae Necessary For Fitness Decrease NAM2
172442 nars-1 asparagiNyl tRNA Synthetase Caenorhabditis elegans Anti-Longevity 11% Increase nars-1
180407 nas-38 Nematode AStacin protease Caenorhabditis elegans Anti-Longevity Increase nas-38
855091 NAT4 Nat4p Saccharomyces cerevisiae Anti-Longevity 21% Increase NAT4
184953 ncbp-2 Nuclear Cap-Binding Protein Caenorhabditis elegans Pro-Longevity 24% Decrease ncbp-2
20602 Ncor2 nuclear receptor co-repressor 2 Mus musculus Pro-Longevity 50% Decrease Ncor2
856101 NCR1 Niemann-pick type C Related Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NCR1
31762 ND75 NADH:ubiquinone reductase 75kD subunit precursor Drosophila melanogaster Anti-Longevity 15% Increase ND75
855176 NDE1 NADH-ubiquinone reductase (H(+)-translocating) NDE1 Saccharomyces cerevisiae Unclear 25% Increase NDE1
851474 NDE2 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae Pro-Longevity 25% Increase NDE2
175582 ndg-4 hypothetical protein Caenorhabditis elegans Anti-Longevity 71% Increase ndg-4
854919 NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae Unclear Increase and Decrease NDI1
172939 ndk-1 Nucleoside diphosphate kinase Caenorhabditis elegans Anti-Longevity Increase ndk-1
2543111 ndk1 nucleoside diphosphate kinase Ndk1 Schizosaccharomyces pombe Anti-Longevity Increase ndk1
856524 NDT80 Ndt80p Saccharomyces cerevisiae Pro-Longevity Increase NDT80
188912 nduf-2.2 NADH Ubiquinone oxidoreductase Fe-S protein Caenorhabditis elegans Anti-Longevity 20% Increase nduf-2.2
72774 Neil1 nei endonuclease VIII-like 1 (E. coli) Mus musculus Pro-Longevity Decrease Neil1
855875 NEW1 New1p Saccharomyces cerevisiae Unannotated NEW1
43149 Nf1 Neurofibromin 1 Drosophila melanogaster Pro-Longevity 68% Increase Nf1
174225 nfi-1 NFI (Nuclear Factor I) family Caenorhabditis elegans Pro-Longevity Decrease nfi-1
18033 Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus Pro-Longevity 33% Decrease Nfkb1
853826 NFU1 NifU-like protein Saccharomyces cerevisiae Necessary For Fitness Decrease NFU1
187340 nhr-119 Protein NHR-119 Caenorhabditis elegans Pro-Longevity 10% Decrease nhr-119
181102 nhr-14 Nuclear Hormone Receptor family Caenorhabditis elegans Anti-Longevity Increase nhr-14
182565 nhr-154 Nuclear Hormone Receptor family Caenorhabditis elegans Anti-Longevity Increase nhr-154
172460 nhr-23 Protein NHR-23 Caenorhabditis elegans Anti-Longevity 5% Increase nhr-23
181432 nhr-25 Protein NHR-25 Caenorhabditis elegans Pro-Longevity 8% Decrease nhr-25
185603 nhr-265 Protein NHR-265 Caenorhabditis elegans Anti-Longevity 4% Increase nhr-265
172839 nhr-49 Nuclear Hormone Receptor family Caenorhabditis elegans Pro-Longevity 56% Decrease nhr-49
191726 nhr-77 Protein NHR-77 Caenorhabditis elegans Pro-Longevity 7% Decrease nhr-77
177551 nhr-8 Nuclear hormone receptor family member nhr-8 Caenorhabditis elegans Pro-Longevity 35% Decrease nhr-8
174242 nhx-2 Na/H eXchanger Caenorhabditis elegans Anti-Longevity 40% Increase nhx-2
855929 NIP100 Nuclear ImPort Saccharomyces cerevisiae Necessary For Fitness Decrease NIP100
3565648 nkcc-1 Protein NKCC-1 Caenorhabditis elegans Anti-Longevity 23% Increase nkcc-1
33324 NLaz Neural Lazarillo Drosophila melanogaster Pro-Longevity 31% Decrease NLaz
184647 nlp-7 Neuropeptide-like protein genes family Caenorhabditis elegans Pro-Longevity 10% Decrease nlp-7
855600 NMA111 Nuclear Mediator of Apoptosis Saccharomyces cerevisiae Pro-Longevity Increase NMA111
856476 NMD2 Nonsense-mediated MRNA Decay Saccharomyces cerevisiae Necessary For Fitness Decrease NMD2
851077 NMD4 Nonsense-Mediated mRNA Decay Saccharomyces cerevisiae Unclear Increase and Decrease NMD4
47895 Nmdmc NAD-dependent methylenetetrahydrofolate dehydrogenase Drosophila melanogaster Pro-Longevity 120% Increase Nmdmc
850892 NMT1 N-Myristoyl Transferase Saccharomyces cerevisiae Anti-Longevity 50% Increase NMT1
853683 NNK1 Nitrogen Network Kinase Saccharomyces cerevisiae Anti-Longevity Increase NNK1
180884 nnt-1 Nicotinamide Nucleotide Transhydrogenase Caenorhabditis elegans Pro-Longevity 18% Decrease nnt-1
173437 nol-1 NucleOLar protein Caenorhabditis elegans Anti-Longevity 31% Increase nol-1
171901 nol-5 NucleOLar protein Caenorhabditis elegans Anti-Longevity 15% Increase nol-5
18127 Nos3 nitric oxide synthase 3, endothelial cell Mus musculus Pro-Longevity Decrease Nos3
179095 npa-1 Nematode Polyprotein Allergen related Caenorhabditis elegans Anti-Longevity 32% Increase npa-1
42018 NPF neuropeptide F Drosophila melanogaster Anti-Longevity 25% Decrease NPF
852042 NPL3 Nuclear Protein Localization Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NPL3
172611 npp-2 Nuclear Pore complex Protein Caenorhabditis elegans Pro-Longevity 11% Decrease npp-2
174823 npp-3 Nuclear Pore complex Protein Caenorhabditis elegans Pro-Longevity 14% Decrease npp-3
854384 NPT1 Nicotinatephosphoribosyltranfserase Saccharomyces cerevisiae Pro-Longevity Increase and Decrease NPT1
855594 NRK1 Nicotinamide Riboside Kinase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease NRK1
179503 nrx-1 GLIoTactin (Drosophila neuroligin-like) homolog Caenorhabditis elegans Anti-Longevity Decrease nrx-1
853064 NSR1 Nsr1p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NSR1
855633 NST1 Negatively affects Salt Tolerance Saccharomyces cerevisiae Unclear Increase and Decrease NST1
191128 nstp-3 Protein NSTP-3 Caenorhabditis elegans Pro-Longevity 29% Decrease nstp-3
175153 nsun-5 Nop2 (NOP2)/SUN domain family member Caenorhabditis elegans Anti-Longevity 17% Increase nsun-5
851564 NTH1 Neutral TreHalase Saccharomyces cerevisiae Necessary For Fitness 15% Decrease NTH1
176614 ntl-3 NOT-Like (yeast CCR4/NOT complex component) Caenorhabditis elegans Pro-Longevity Decrease ntl-3
181174 nuc-1 abnormal NUClease Caenorhabditis elegans Anti-Longevity Increase nuc-1
4521 NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 Mus musculus Pro-Longevity 16% Increase NUDT1
176048 numr-1 NUclear localized Metal Responsive Caenorhabditis elegans Pro-Longevity Increase numr-1
176049 numr-2 NUclear localized Metal Responsive Caenorhabditis elegans Pro-Longevity Increase numr-2
174696 nuo-1 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity 50% Increase nuo-1
172363 nuo-2 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity Increase nuo-2
178404 nuo-3 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity 77% Increase nuo-3
176001 nuo-4 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity 38% Increase nuo-4
178735 nuo-5 NADH Ubiquinone Oxidoreductase Caenorhabditis elegans Anti-Longevity Increase nuo-5
172438 nuo-6 Protein NUO-6 Caenorhabditis elegans Anti-Longevity 73% Increase nuo-6
852199 NUP170 NUclear Pore Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NUP170
850782 NYV1 New Yeast V-SNARE Saccharomyces cerevisiae Necessary For Fitness 50% Decrease NYV1
188314 ocr-2 Osm-9 and Capsaicin receptor-Related Caenorhabditis elegans Anti-Longevity Increase ocr-2
179098 odr-2 hypothetical protein Caenorhabditis elegans Anti-Longevity 25% Increase odr-2
179806 odr-3 ODoRant response abnormal Caenorhabditis elegans Anti-Longevity 30% Increase odr-3
181403 odr-7 Nuclear hormone receptor family member odr-7 Caenorhabditis elegans Anti-Longevity 27% Increase odr-7
177235 ogdh-1 Protein OGDH-1 Caenorhabditis elegans Anti-Longevity 79% Increase ogdh-1
191737 old-1 Overexpression Longevity Determinant Caenorhabditis elegans Pro-Longevity 65% Increase old-1
854670 OM45 Outer Membrane Saccharomyces cerevisiae Anti-Longevity Increase OM45
853962 OMA1 Overlapping activity with M-AAA protease Saccharomyces cerevisiae Necessary For Fitness 70% Decrease OMA1
853536 OPI3 OverProducer of Inositol Saccharomyces cerevisiae Necessary For Fitness Decrease OPI3
856324 OPT2 OligoPeptide Transporter 2 Saccharomyces cerevisiae Anti-Longevity 23% Increase OPT2
40650 Orco Odorant receptor co-receptor Drosophila melanogaster Anti-Longevity 56% Increase Orco
851543 OSH2 OxySterol binding protein Homolog Saccharomyces cerevisiae Necessary For Fitness Decrease OSH2
853872 OSH6 oxysterol-binding protein OSH6 Saccharomyces cerevisiae Pro-Longevity 23% Increase OSH6
181715 osm-1 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity 40% Increase osm-1
177141 osm-3 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity Increase osm-3
180585 osm-5 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity 150% Increase osm-5
179631 osm-6 OSMotic avoidance abnormal Caenorhabditis elegans Anti-Longevity 40% Increase osm-6
854252 OST3 dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 Saccharomyces cerevisiae Anti-Longevity 20% Increase OST3
31429 ovo CG6824-PA Drosophila melanogaster Anti-Longevity 50% Increase ovo
34780 p38b CG7393-PA Drosophila melanogaster Pro-Longevity 60% Decrease p38b
2768677 p53 CG33336-PA Drosophila melanogaster Anti-Longevity 58% Increase p53
851643 PAA1 PolyAmine Acetyltransferase Saccharomyces cerevisiae Necessary For Fitness Decrease PAA1
172920 pab-1 PolyA Binding protein Caenorhabditis elegans Anti-Longevity 30% Increase pab-1
181473 pab-2 PolyA Binding protein Caenorhabditis elegans Anti-Longevity Increase pab-2
852969 PAC10 Protein required in the Absence of Cin8p Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PAC10
180873 pak-1 Serine/threonine-protein kinase pak-1 Caenorhabditis elegans Unannotated 50% Increase pak-1
18491 Pappa Pregnancy-associated plasma protein A Mus musculus Anti-Longevity 30% Increase Pappa
178113 par-5 abnormal embryonic PARtitioning of cytoplasm Caenorhabditis elegans Pro-Longevity Increase and Decrease par-5
2539379 par1 protein phosphatase regulatory subunit Par1 Schizosaccharomyces pombe Anti-Longevity Increase par1
40336 park parkin Drosophila melanogaster Pro-Longevity 28% Increase park
11545 Parp1 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase) Mus musculus Pro-Longevity 25% Decrease Parp1
172950 pash-1 PArtner of DroSHa (DRSH-1 interactor) Caenorhabditis elegans Pro-Longevity 31% Decrease pash-1
172127 pat-10 Paralysed Arrest at Two-fold Caenorhabditis elegans Pro-Longevity 30% Increase pat-10
175504 pat-3 Protein PAT-3 Caenorhabditis elegans Pro-Longevity 28% Decrease pat-3
175175 pat-4 Paralysed Arrest at Two-fold Caenorhabditis elegans Anti-Longevity 24% Increase pat-4
176848 pat-6 Paralysed Arrest at Two-fold Caenorhabditis elegans Anti-Longevity 60% Increase pat-6
856662 PAU2 seriPAUperin family Saccharomyces cerevisiae Necessary For Fitness Decrease PAU2
114774 Pawr PRKC, apoptosis, WT1, regulator Mus musculus Pro-Longevity Increase and Decrease Pawr
173334 pbs-5 Proteasome subunit beta type Caenorhabditis elegans Pro-Longevity 25% Increase pbs-5
852598 PCA1 P-type Cation-transporting ATPase Saccharomyces cerevisiae Necessary For Fitness Decrease PCA1
246008 pcf-11 Protein PCF-11 Caenorhabditis elegans Pro-Longevity 19% Decrease pcf-11
174313 pch-2 Putative pachytene checkpoint protein 2 Caenorhabditis elegans Pro-Longevity 22% Increase pch-2
852484 PCH2 Pachytene CHeckpoint Saccharomyces cerevisiae Anti-Longevity 50% Increase PCH2
172556 pck-2 R11A5.4b Caenorhabditis elegans Anti-Longevity Increase pck-2
18534 Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus Pro-Longevity Increase Pck1
853972 PCK1 Phosphoenolpyruvate CarboxyKinase Saccharomyces cerevisiae Necessary For Fitness Decrease PCK1
856787 PCL6 Pho85 CycLin Saccharomyces cerevisiae Necessary For Fitness Decrease PCL6
854761 PCL7 Pho85 CycLin Saccharomyces cerevisiae Anti-Longevity Increase PCL7
178981 pcm-1 Protein Carboxymethyltransferase Caenorhabditis elegans Pro-Longevity 30% Increase pcm-1
40668 Pcmt Protein-L-isoaspartate (D-aspartate) O-methyltransferase Drosophila melanogaster Pro-Longevity 39% Increase Pcmt
852993 PCP1 Processing of Cytochrome c Peroxidase Saccharomyces cerevisiae Necessary For Fitness Decrease PCP1
856925 PDA1 Pyruvate Dehydrogenase Alpha Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PDA1
850733 PDC1 Pyruvate DeCarboxylase Saccharomyces cerevisiae Necessary For Fitness Decrease PDC1
854542 PDE2 PhosphoDiEsterase Saccharomyces cerevisiae Necessary For Fitness Decrease PDE2
180475 pdk-1 PDK-class protein kinase Caenorhabditis elegans Anti-Longevity 60% Increase pdk-1
172035 pdp-1 Pyruvate Dehydrogenase Phosphatase homolog Caenorhabditis elegans Pro-Longevity 17% Increase pdp-1
855807 PDR18 Pleiotropic Drug Resistance Saccharomyces cerevisiae Anti-Longevity Increase PDR18
852323 PDX3 PyriDoXine auxotrophy Saccharomyces cerevisiae Anti-Longevity 50% Increase PDX3
2539366 pef1 Pho85/PhoA-like cyclin-dependent kinase Pef1 Schizosaccharomyces pombe Anti-Longevity Increase pef1
854201 PEP12 carboxyPEPtidase Y-deficient Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PEP12
2542423 pep7 prevacuole/endosomal FYVE tethering component Pep7 (predicted) Schizosaccharomyces pombe Necessary For Fitness Decrease pep7
180919 pept-1 OligoPeptide Transporter Caenorhabditis elegans Anti-Longevity 40% Increase pept-1
18627 Per2 period circadian clock 2 Mus musculus Anti-Longevity Increase Per2
173025 pes-2.1 Patterned Expression Site Caenorhabditis elegans Anti-Longevity Increase pes-2.1
855299 PET111 PETite colonies Saccharomyces cerevisiae Necessary For Fitness Decrease PET111
852198 PET112 PETite colonies Saccharomyces cerevisiae Necessary For Fitness Decrease PET112
856786 PET117 PETite colonies Saccharomyces cerevisiae Necessary For Fitness Decrease PET117
854182 PET127 Pet127p Saccharomyces cerevisiae Anti-Longevity 35% Increase PET127
850756 PET309 Pet309p Saccharomyces cerevisiae Anti-Longevity 25% Increase PET309
852250 PET9 PETite colonies Saccharomyces cerevisiae Pro-Longevity 30% Decrease PET9
852724 PEX14 PEroXisome related Saccharomyces cerevisiae Necessary For Fitness Decrease PEX14
40293 Pex16 peroxin 16 Drosophila melanogaster Pro-Longevity 75% Decrease Pex16
853219 PEX2 PEroXin Saccharomyces cerevisiae Necessary For Fitness Decrease PEX2
855991 PEX25 PEroXisome related Saccharomyces cerevisiae Anti-Longevity Increase PEX25
851831 PEX5 PEroXin Saccharomyces cerevisiae Necessary For Fitness Decrease PEX5
855387 PEX6 PEroXin Saccharomyces cerevisiae Necessary For Fitness Decrease PEX6
855390 PFA3 Protein Fatty Acyltransferase Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PFA3
852070 PFA5 Protein Fatty Acyltransferase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PFA5
180808 pfn-2 ProFiliN Caenorhabditis elegans Anti-Longevity Increase pfn-2
854914 PGA3 Processing of Gas1p and ALP Saccharomyces cerevisiae Pro-Longevity 30% Increase PGA3
171746 pghm-1 Protein PGHM-1 Caenorhabditis elegans Anti-Longevity Increase pghm-1
177461 pgl-1 P GranuLe abnormality Caenorhabditis elegans Anti-Longevity Increase pgl-1
180357 pha-4 defective PHArynx development Caenorhabditis elegans Pro-Longevity 13% Decrease pha-4
171768 phb-1 mitochondrial ProHiBitin complex Caenorhabditis elegans Pro-Longevity Decrease phb-1
174034 phb-2 mitochondrial ProHiBitin complex Caenorhabditis elegans Pro-Longevity Decrease phb-2
853033 PHB1 Phb1p Saccharomyces cerevisiae Pro-Longevity 20% Decrease PHB1
853146 PHB2 Phb2p Saccharomyces cerevisiae Pro-Longevity 30% Decrease PHB2
853823 PHD1 PseudoHyphal Determinant Saccharomyces cerevisiae Anti-Longevity 20% Increase PHD1
851452 PHO2 PHOsphate metabolism Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PHO2
855626 PHO23 PHOsphate metabolism Saccharomyces cerevisiae Necessary For Fitness Decrease PHO23
854916 PHO84 phosphate transporter PHO84 Saccharomyces cerevisiae Pro-Longevity 14% Increase PHO84
856076 PHO85 PHOsphate metabolism Saccharomyces cerevisiae Necessary For Fitness 45% Decrease PHO85
852599 PHO89 PHOsphate metabolism Saccharomyces cerevisiae Anti-Longevity 50% Increase PHO89
2541161 php2 CCAAT-binding factor complex subunit Php2 Schizosaccharomyces pombe Anti-Longevity Increase php2
42446 Pi3K92E CG4141 gene product from transcript CG4141-RA Drosophila melanogaster Pro-Longevity 5% Decrease Pi3K92E
851908 PIB1 PhosphatidylInositol(3)-phosphate Binding Saccharomyces cerevisiae Anti-Longevity 25% Increase PIB1
852259 PIM1 Proteolysis In Mitochondria Saccharomyces cerevisiae Necessary For Fitness 50% Decrease PIM1
856277 PIN3 Psi+ INducibility Saccharomyces cerevisiae Anti-Longevity 15% Increase PIN3
31607 Pink1 PTEN-induced putative kinase 1 Drosophila melanogaster Pro-Longevity 18% Increase Pink1
34284 Pka-C1 cAMP-dependent protein kinase 1 Drosophila melanogaster Pro-Longevity Increase Pka-C1
2539781 pka1 cAMP-dependent protein kinase Schizosaccharomyces pombe Unannotated Increase pka1
176991 pkg-1 EGg Laying defective Caenorhabditis elegans Anti-Longevity 55% Increase pkg-1
852101 PKH1 Pkb-activating Kinase Homolog Saccharomyces cerevisiae Anti-Longevity 15% Increase PKH1
854053 PKH2 Pkb-activating Kinase Homolog Saccharomyces cerevisiae Anti-Longevity 20% Increase PKH2
852077 PKH3 Pkb-activating Kinase Homolog Saccharomyces cerevisiae Anti-Longevity 10% Increase PKH3
18792 Plau Plasminogen activator, urokinase Mus musculus Pro-Longevity 20% Increase Plau
266823 pme-1 Protein PME-1 Caenorhabditis elegans Anti-Longevity 29% Increase pme-1
850389 PMP1 Plasma Membrane Proteolipid Saccharomyces cerevisiae Necessary For Fitness Decrease PMP1
851869 PMP3 Plasma Membrane Proteolipid Saccharomyces cerevisiae Necessary For Fitness Decrease PMP3
852709 PMR1 Plasma Membrane ATPase Related Saccharomyces cerevisiae Anti-Longevity 40% Increase PMR1
855642 PMS1 PostMeiotic Segregation Saccharomyces cerevisiae Necessary For Fitness Decrease PMS1
851462 PMT1 Protein O-MannosylTransferase Saccharomyces cerevisiae Necessary For Fitness Decrease PMT1
851464 PMT5 putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 Saccharomyces cerevisiae Anti-Longevity 21% Increase PMT5
851902 PMT7 Pmt7p Saccharomyces cerevisiae Anti-Longevity 30% Increase PMT7
176833 pnc-1 Pyrazinamidase and NiCotinamidase Caenorhabditis elegans Pro-Longevity Decrease pnc-1
852846 PNC1 Pyrazinamidase and NiCotinamidase Saccharomyces cerevisiae Pro-Longevity Increase and Decrease PNC1
172327 pnk-1 PaNtothenate Kinase Caenorhabditis elegans Pro-Longevity Decrease pnk-1
854440 PNT1 PeNTamidine resistance Saccharomyces cerevisiae Necessary For Fitness Decrease PNT1
176784 pod-1 Polarity and Osmotic sensitivity Defect Caenorhabditis elegans Anti-Longevity 45% Increase pod-1
6194500 PODANSg7134 hypothetical protein Podospora anserina Anti-Longevity 18% Increase PODANSg7134
854684 POG1 Promoter Of Growth Saccharomyces cerevisiae Necessary For Fitness Decrease POG1
18975 Polg Polymerase (DNA directed), gamma Mus musculus Pro-Longevity Decrease Polg
179224 pos-1 POsterior Segregation Caenorhabditis elegans Anti-Longevity 20% Increase pos-1
36990 POSH Plenty of SH3s Drosophila melanogaster Pro-Longevity 14% Increase POSH
18736 Pou1f1 POU domain, class 1, transcription factor 1 Mus musculus Anti-Longevity 40% Increase Pou1f1
855309 PPA2 PyroPhosphatAse Saccharomyces cerevisiae Necessary For Fitness Decrease PPA2
19016 Pparg Peroxisome proliferator activated receptor gamma Mus musculus Pro-Longevity Increase and Decrease Pparg
851647 PPH3 Protein PHosphatase Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PPH3
32731 ppk23 pickpocket 23 Drosophila melanogaster Anti-Longevity 4% Decrease ppk23
32671 ppk28 pickpocket 28 Drosophila melanogaster Anti-Longevity 44% Increase ppk28
53892 Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform Mus musculus Pro-Longevity Decrease Ppm1d
2541963 ppr1 L-azetidine-2-carboxylic acid acetyltransferase Schizosaccharomyces pombe Anti-Longevity Increase ppr1
854992 PPZ1 Protein Phosphatase Z Saccharomyces cerevisiae Necessary For Fitness Decrease PPZ1
266858 prdx-2 PeRoxireDoXin Caenorhabditis elegans Pro-Longevity Decrease prdx-2
175573 prdx-3 PeRoxireDoXin Caenorhabditis elegans Pro-Longevity Decrease prdx-3
18477 Prdx1 Peroxiredoxin 1 Mus musculus Pro-Longevity Decrease Prdx1
853036 PRE9 proteasome core particle subunit alpha 3 Saccharomyces cerevisiae Necessary For Fitness 20% Decrease PRE9
854713 PRK1 p53 Regulatory Kinase Saccharomyces cerevisiae Anti-Longevity 30% Increase PRK1
19088 Prkar2b protein kinase, cAMP dependent regulatory, type II beta Mus musculus Anti-Longevity 14% Increase Prkar2b
19127 Prop1 Prophet of Pit1, paired-like homeodomain transcription factor Mus musculus Anti-Longevity Increase Prop1
856375 PRS3 PhosphoRibosylpyrophosphate Synthetase Saccharomyces cerevisiae Anti-Longevity 50% Increase PRS3
174392 prx-5 PeRoXisome assembly factor Caenorhabditis elegans Anti-Longevity 30% Increase prx-5
852215 PRX1 PeroxiRedoXin Saccharomyces cerevisiae Necessary For Fitness Decrease PRX1
3771951 Prx5 Peroxiredoxin 5 Drosophila melanogaster Pro-Longevity 30% Increase Prx5
853366 PRY1 Pathogen Related in Yeast Saccharomyces cerevisiae Necessary For Fitness 50% Decrease PRY1
855552 PSD1 PhosphatidylSerine Decarboxylase Saccharomyces cerevisiae Necessary For Fitness Decrease PSD1
851596 PST2 Pst2p Saccharomyces cerevisiae Anti-Longevity 36% Increase PST2
854257 PTC5 Phosphatase Two C Saccharomyces cerevisiae Necessary For Fitness 50% Decrease PTC5
43991 Pten CG5671 gene product from transcript CG5671-RB Drosophila melanogaster Pro-Longevity 13% Increase Pten
19211 Pten Phosphatase and tensin homolog Mus musculus Pro-Longevity Increase and Decrease Pten
856596 PTH1 Peptidyl-Trna Hydrolase Saccharomyces cerevisiae Necessary For Fitness Decrease PTH1
853522 PTK2 Putative serine/Threonine protein Kinase Saccharomyces cerevisiae Necessary For Fitness Decrease PTK2
173362 ptr-23 PaTched Related family Caenorhabditis elegans Pro-Longevity 13% Decrease ptr-23
855716 PUB1 PolyUridylate Binding Saccharomyces cerevisiae Necessary For Fitness 25% Decrease PUB1
40958 puc puckered Drosophila melanogaster Anti-Longevity Increase puc
851132 PUN1 Plasma membrane protein Upregulated during Nitrogen stress Saccharomyces cerevisiae Necessary For Fitness Decrease PUN1
175708 pup-2 Poly(U) Polymerase Caenorhabditis elegans Anti-Longevity Increase pup-2
853965 PXL1 PaXillin-Like protein Saccharomyces cerevisiae Anti-Longevity Increase PXL1
179616 pyc-1 PYruvate Carboxylase Caenorhabditis elegans Anti-Longevity 5% Increase pyc-1
178415 qars-1 glutaminyl(Q) tRNA Synthetase Caenorhabditis elegans Anti-Longevity 40% Increase qars-1
852142 QCR7 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae Necessary For Fitness 30% Decrease QCR7
853273 QCR8 ubiQuinol-cytochrome C oxidoReductase Saccharomyces cerevisiae Necessary For Fitness Decrease QCR8
850901 QRI5 Qri5p Saccharomyces cerevisiae Necessary For Fitness Decrease QRI5
180862 R07E4.3 hypothetical protein Caenorhabditis elegans Anti-Longevity 20% Increase R07E4.3
180757 R08E3.3 Protein R08E3.3 Caenorhabditis elegans Anti-Longevity Increase R08E3.3
177932 R10H10.7 Protein R10H10.7 Caenorhabditis elegans Anti-Longevity 22% Increase R10H10.7
187837 R12B2.6 Protein R12B2.6 Caenorhabditis elegans Pro-Longevity 22% Decrease R12B2.6
172011 R12E2.2 hypothetical protein Caenorhabditis elegans Anti-Longevity 50% Increase R12E2.2
174554 R53.4 Protein R53.4 Caenorhabditis elegans Anti-Longevity 20% Increase R53.4
266836 rab-10 RAB family Caenorhabditis elegans Anti-Longevity 16% Increase rab-10
172755 rab-5 RAB family Caenorhabditis elegans Pro-Longevity 50% Decrease rab-5
174834 rab-7 RAB family Caenorhabditis elegans Pro-Longevity 32% Decrease rab-7
177895 rack-1 Guanine nucleotide-binding protein subunit beta-2-like 1 Caenorhabditis elegans Anti-Longevity 10% Increase rack-1
854878 RAD10 RADiation sensitive Saccharomyces cerevisiae Necessary For Fitness Decrease RAD10
853747 RAD27 Rad27p Saccharomyces cerevisiae Pro-Longevity 50% Decrease RAD27
851909 RAD34 Homologous to RAD4 Saccharomyces cerevisiae Anti-Longevity 30% Increase RAD34
856909 RAD4 RADiation sensitive Saccharomyces cerevisiae Necessary For Fitness Decrease RAD4
855471 RAD50 Subunit of MRX complex, with Mre11p and Xrs2p Saccharomyces cerevisiae Necessary For Fitness 70% Decrease RAD50
856831 RAD51 Strand exchange protein Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RAD51
854976 RAD52 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) Saccharomyces cerevisiae Necessary For Fitness 70% Decrease RAD52
851648 RAD55 RADiation sensitive Saccharomyces cerevisiae Unclear Increase and Decrease RAD55
851567 RAD57 Rad57p Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RAD57
851803 RAD9 Rad9p Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RAD9
66679 Rae1 RAE1 RNA export 1 homolog (S. pombe) Mus musculus Pro-Longevity Decrease Rae1
174726 raga-1 RAs-related GTP-binding protein A Caenorhabditis elegans Anti-Longevity 27% Increase raga-1
178084 ragc-1 RAs-related GTP binding protein C homolog Caenorhabditis elegans Anti-Longevity 26% Increase ragc-1
175433 ral-1 RAL (Ras-related GTPase) homolog Caenorhabditis elegans Anti-Longevity 19% Increase ral-1
175659 rars-1 Probable arginine--tRNA ligase, cytoplasmic Caenorhabditis elegans Anti-Longevity 27% Increase rars-1
854268 RAS1 GTPase involved in G-protein signaling in the adenylate cyclase activating pathway Saccharomyces cerevisiae Anti-Longevity 23% Increase RAS1
855625 RAS2 GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous gr Saccharomyces cerevisiae Unclear 43% Increase RAS2
853490 RAV1 Regulator of (H+)-ATPase in Vacuolar membrane Saccharomyces cerevisiae Necessary For Fitness Decrease RAV1
31381 rb ruby Drosophila melanogaster Pro-Longevity Decrease rb
56190 Rbm38 RNA binding motif protein 38 Mus musculus Pro-Longevity 22% Decrease Rbm38
33498 Rbp9 RNA-binding protein 9 Drosophila melanogaster Pro-Longevity 33% Decrease Rbp9
177985 rbr-2 RB (Retinoblastoma Binding protein) Related Caenorhabditis elegans Unclear Increase and Decrease rbr-2
855709 RCM1 Rcm1p Saccharomyces cerevisiae Anti-Longevity Increase RCM1
175522 rcq-5 ReCQ DNA helicase family Caenorhabditis elegans Pro-Longevity 37% Decrease rcq-5
851566 RCR2 Resistance to Congo Red 2 Saccharomyces cerevisiae Anti-Longevity 18% Increase RCR2
853226 RCY1 Rcy1p Saccharomyces cerevisiae Anti-Longevity Increase RCY1
31826 rdgA retinal degeneration A Drosophila melanogaster Anti-Longevity 44% Increase rdgA
2769007 Rdh CG14975-PA Drosophila melanogaster Pro-Longevity 8% Increase Rdh
2539930 reb1 RNA polymerase I transcription termination factor Reb1 Schizosaccharomyces pombe Anti-Longevity Increase reb1
178295 rec-8 hypothetical protein Caenorhabditis elegans Anti-Longevity 26% Increase rec-8
856115 REC8 Rec8p Saccharomyces cerevisiae Anti-Longevity 20% Increase REC8
851592 REG1 protein phosphatase regulator REG1 Saccharomyces cerevisiae Necessary For Fitness Decrease REG1
852569 REI1 Cytoplasmic pre-60S factor Saccharomyces cerevisiae Anti-Longevity 40% Increase REI1
850873 RFX1 Rfx1p Saccharomyces cerevisiae Anti-Longevity 20% Increase RFX1
854274 RGS2 Regulator of heterotrimeric G protein Signaling Saccharomyces cerevisiae Anti-Longevity 35% Increase RGS2
853828 RGT1 Restores Glucose Transport Saccharomyces cerevisiae Anti-Longevity Increase RGT1
851417 RGT2 Restores Glucose Transport Saccharomyces cerevisiae Anti-Longevity Increase RGT2
176207 rha-2 RNA HelicAse Caenorhabditis elegans Anti-Longevity 32% Increase rha-2
176327 rheb-1 Protein RHEB-1 Caenorhabditis elegans Anti-Longevity 19% Increase rheb-1
180721 rhi-1 RHo GDI Caenorhabditis elegans Pro-Longevity Decrease rhi-1
36281 rho-7 rhomboid-7 Drosophila melanogaster Pro-Longevity Decrease rho-7
855541 RHO5 Ras HOmolog Saccharomyces cerevisiae Necessary For Fitness Decrease RHO5
179427 ric-4 Resistance to Inhibitors of Cholinesterase Caenorhabditis elegans Anti-Longevity Decrease ric-4
3565035 rict-1 hypothetical protein Caenorhabditis elegans Unannotated 10% Increase rict-1
78757 Rictor RPTOR independent companion of MTOR, complex 2 Mus musculus Pro-Longevity 40% Decrease Rictor
852578 RIF1 RAP1-Interacting Factor Saccharomyces cerevisiae Pro-Longevity 30% Decrease RIF1
179958 ril-1 RNAi-Induced Longevity Caenorhabditis elegans Anti-Longevity 32% Increase ril-1
179725 ril-2 RNAi-Induced Longevity Caenorhabditis elegans Anti-Longevity Increase ril-2
850395 RIM1 Replication In Mitochondria Saccharomyces cerevisiae Anti-Longevity 20% Increase RIM1
855170 RIM11 Regulator of IME2 Saccharomyces cerevisiae Necessary For Fitness Decrease RIM11
850511 RIM15 Regulator of IME2 Saccharomyces cerevisiae Necessary For Fitness Decrease RIM15
852837 RIM8 Regulator of IME2 Saccharomyces cerevisiae Unclear Increase and Decrease RIM8
856689 RIP1 Rieske Iron-sulfur Protein Saccharomyces cerevisiae Anti-Longevity 15% Increase RIP1
855289 RKR1 RING domain mutant Killed by rtf1 deletion Saccharomyces cerevisiae Necessary For Fitness Decrease RKR1
172943 rla-0 60S acidic ribosomal protein P0 Caenorhabditis elegans Anti-Longevity 7% Increase rla-0
176525 rle-1 Regulation of Longevity by E3 ubiquitin ligase Caenorhabditis elegans Anti-Longevity Increase rle-1
856016 RLM1 Resistance to Lethality of MKK1P386 overexpression Saccharomyces cerevisiae Necessary For Fitness Decrease RLM1
850609 RMD8 Required for Meiotic nuclear Division Saccharomyces cerevisiae Necessary For Fitness Decrease RMD8
852771 RMD9 Required for Meiotic nuclear Division Saccharomyces cerevisiae Necessary For Fitness Decrease RMD9
175532 rnf-5 RiNg Finger protein Caenorhabditis elegans Anti-Longevity Increase rnf-5
855652 RNH201 RNase H Saccharomyces cerevisiae Anti-Longevity 50% Increase RNH201
175525 rnr-2 Protein RNR-2 Caenorhabditis elegans Anti-Longevity 14% Increase rnr-2
854744 RNR3 RiboNucleotide Reductase Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RNR3
851086 ROM2 GDP/GTP exchange protein (GEP) for Rho1p and Rho2p Saccharomyces cerevisiae Anti-Longevity 50% Increase ROM2
855300 ROY1 Repressor Of Ypt52 Saccharomyces cerevisiae Necessary For Fitness Decrease ROY1
174238 rpa-1 Protein RPA-1 Caenorhabditis elegans Anti-Longevity 5% Increase rpa-1
175660 rpb-8 Protein RPB-8 Caenorhabditis elegans Anti-Longevity 6% Increase rpb-8
855386 RPD3 Histone deacetylase Saccharomyces cerevisiae Anti-Longevity 41% Increase RPD3
38565 Rpd3 CG7471-PA Drosophila melanogaster Anti-Longevity 52% Increase Rpd3
246599 Rpi Ribose-5-phosphate isomerase Drosophila melanogaster Anti-Longevity 38% Increase Rpi
171853 rpl-1 60S ribosomal protein L10a Caenorhabditis elegans Anti-Longevity 23% Increase rpl-1
174311 rpl-10 60S ribosomal protein L10 Caenorhabditis elegans Anti-Longevity 20% Increase rpl-10
171692 rpl-17 60S ribosomal protein L17 Caenorhabditis elegans Anti-Longevity 13% Increase rpl-17
172201 rpl-19 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity Increase rpl-19
175796 rpl-23 60S ribosomal protein L23 Caenorhabditis elegans Anti-Longevity 18% Increase rpl-23
175501 rpl-3 60S ribosomal protein L3 Caenorhabditis elegans Anti-Longevity 29% Increase rpl-3
172921 rpl-30 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity 13% Increase rpl-30
173235 rpl-31 60S ribosomal protein L31 Caenorhabditis elegans Anti-Longevity 16% Increase rpl-31
172074 rpl-4 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity Increase rpl-4
171602 rpl-7 60S ribosomal protein L7 Caenorhabditis elegans Anti-Longevity 10% Increase rpl-7
177203 rpl-7A 60S ribosomal protein L7a Caenorhabditis elegans Anti-Longevity 12% Increase rpl-7A
176071 rpl-9 Ribosomal Protein, Large subunit Caenorhabditis elegans Anti-Longevity Increase rpl-9
850764 RPL10 ribosomal 60S subunit protein L10 Saccharomyces cerevisiae Anti-Longevity 24% Increase RPL10
856656 RPL12A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 35% Increase RPL12A
852026 RPL12B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL12B
851477 RPL13A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL13A
855173 RPL13B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RPL13B
855655 RPL16B ribosomal 60S subunit protein L16B Saccharomyces cerevisiae Anti-Longevity 23% Increase RPL16B
853262 RPL17B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 25% Decrease RPL17B
852379 RPL19A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 50% Increase RPL19A
852254 RPL19B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL19B
852742 RPL1B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL1B
855283 RPL20A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 40% Decrease RPL20A
854489 RPL20B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 50% Increase RPL20B
852489 RPL21A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL21A
856026 RPL21B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 50% Increase RPL21B
850750 RPL22A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 90% Increase RPL22A
852191 RPL23A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 40% Increase RPL23A
851058 RPL26A ribosomal 60S subunit protein L26A Saccharomyces cerevisiae Anti-Longevity 22% Increase RPL26A
850592 RPL29 Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 35% Increase RPL29
854794 RPL2B ribosomal 60S subunit protein L2B Saccharomyces cerevisiae Anti-Longevity 38% Increase RPL2B
851484 RPL31A ribosomal 60S subunit protein L31A Saccharomyces cerevisiae Unclear Increase and Decrease RPL31A
854409 RPL33B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 15% Increase RPL33B
856784 RPL34A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 25% Decrease RPL34A
854759 RPL34B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 60% Increase RPL34B
851336 RPL35A ribosomal 60S subunit protein L35A Saccharomyces cerevisiae Anti-Longevity 41% Increase RPL35A
851419 RPL35B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 25% Increase RPL35B
850882 RPL37A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 50% Decrease RPL37A
852111 RPL37B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 35% Increase RPL37B
853250 RPL39 Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 45% Decrease RPL39
856156 RPL43A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 60% Decrease RPL43A
853557 RPL43B Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 30% Increase RPL43B
852319 RPL4A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Anti-Longevity 20% Increase RPL4A
854902 RPL6A Ribosomal Protein of the Large subunit Saccharomyces cerevisiae Necessary For Fitness 25% Decrease RPL6A
851169 RPL6B ribosomal 60S subunit protein L6B Saccharomyces cerevisiae